{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T16:43:44Z","timestamp":1790873024331,"version":"4.1.0"},"reference-count":37,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Neurovascular compression (NVC) of the trigeminal nerve is associated with trigeminal neuralgia (TN), but also occurs in many patients without facial pain. This study is designed to identify anatomical characteristics of NVC associated with TN.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty patients with Type 1 TN (intermittent shocklike pain) and 15 patients without facial pain underwent imaging for analysis of 30 trigeminal nerves ipsilateral to TN symptoms, 30 contralateral to TN symptoms, and 30 in asymptomatic patients. Patients underwent 3-T MR imaging including balanced fast-field echo and MR angiography. Images were fused and reconstructed into virtual cisternoscopy images that were evaluated to determine the presence and degree of NVC. Reconstructed coronal images were used to measure nerve diameter and crosssectional area.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The incidence of arterial NVC in asymptomatic nerves, nerves contralateral to TN symptoms, and nerves ipsilateral to TN symptoms was 17%, 43%, and 57%, respectively. The difference between symptomatic and asymptomatic nerves was significant regarding the presence of NVC, nerve distortion, and the site of compression (p &lt; 0.001, Fisher exact test). The most significant predictors of TN were compression of the proximal nerve (odds ratio 10.4) and nerve indentation or displacement (odds ratio 4.3). There was a tendency for the development of increasingly severe nerve compression with more advanced patient age across all groups. Decreased nerve size was observed in patients with TN but did not correlate with the presence or extent of NVC.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Trigeminal NVC occurs in asymptomatic patients but is more severe and more proximal in patients with TN. This information may help identify patients who are likely to benefit from microvascular decompression.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.6.17620","type":"journal-article","created":{"date-parts":[[2008,10,24]],"date-time":"2008-10-24T14:49:30Z","timestamp":1224859770000},"page":"627-632","source":"Crossref","is-referenced-by-count":123,"title":["Radiographic evaluation of trigeminal neurovascular compression in patients with and without trigeminal neuralgia"],"prefix":"10.3171","volume":"110","author":[{"given":"Jonathan P.","family":"Miller","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Feridun","family":"Acar","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bronwyn E.","family":"Hamilton","sequence":"additional","affiliation":[{"name":"Diagnostic Radiology, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kim J.","family":"Burchiel","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-17620","series-title":"Neurosurgery","first-page":"956","article-title":"Preoperative evaluation of neurovascular compression in patients with trigeminal neuralgia by use of three-dimensional reconstruction from two types of high-resolution magnetic resonance imaging","volume":"51","author":"Akimoto","year":"2002"},{"key":"b2-17620","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"666","DOI":"10.1227\/01.NEU.0000197117.34888.DE","article-title":"High-resolution three-dimensional magnetic resonance angiography and three-dimensional spoiled gradient-recalled imaging in the evaluation of neurovascular compression in patients with trigeminal neuralgia: a doubleblind pilot study","volume":"58","author":"Anderson","year":"2006"},{"key":"b3-17620","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1077","DOI":"10.1056\/NEJM199604253341701","article-title":"The long-term outcome of microvascular decompression for trigeminal neuralgia","volume":"334","author":"Barker","year":"1996"},{"key":"b4-17620","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"1164","DOI":"10.1227\/01.NEU.0000088806.11659.D8","article-title":"A new classification for facial pain","volume":"53","author":"Burchiel","year":"2003"},{"key":"b5-17620","series-title":"Am J Surg","doi-asserted-by":"publisher","first-page":"447","DOI":"10.1016\/S0002-9610(34)90403-7","article-title":"Concerning the cause of trigeminal neuralgia","volume":"24","author":"Dandy","year":"1934"},{"key":"b6-17620","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"532","DOI":"10.3171\/jns.2002.96.3.0532","article-title":"Mechanism of trigeminal neuralgia: an ultrastructural analysis of trigeminal root specimens obtained during microvascular decompression surgery","volume":"96","author":"Devor","year":"2002"},{"key":"b7-17620","series-title":"Semin Neurosurg","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1055\/s-2004-830014","article-title":"Trigeminal neuralgia and other craniofacial pain syndromes: an overview","volume":"15","author":"Elias","year":"2004"},{"key":"b8-17620","series-title":"Radiology","doi-asserted-by":"publisher","first-page":"689","DOI":"10.1148\/radiol.2382042214","article-title":"Nerve atrophy in severe trigeminal neuralgia: noninvasive confirmation at MR imaging\u2014initial experience","volume":"238","author":"Erbay","year":"2006"},{"key":"b9-17620","series-title":"Trigeminal Neuralgia: Current Concepts Regarding Pathogenesis and Treatment","author":"Fromm","year":"1991"},{"key":"b10-17620","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"381","DOI":"10.3171\/jns.1980.52.3.0381","article-title":"Microvascular relations of the trigeminal nerve. 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