{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,8]],"date-time":"2026-03-08T23:57:18Z","timestamp":1773014238938,"version":"3.50.1"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The authors describe the utility of and outcomes after endoscopic transnasal craniotomy and skull reconstruction in the management of skull base pathologies.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors conducted a observational study of patients undergoing totally endoscopic, transnasal, transdural surgery. The patients included in the study underwent treatment over a 12-month period at 2 tertiary medical centers. The pathological entity, region of the ventral skull base resected, and size of the dural defect were recorded. Approach-related complications were documented, as well as CSF leaks, infections, bleeding-related complications, and any minor complications.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Thirty consecutive patients were assessed during the study period. The patients had a mean age of 45.5 \u00b1 20.2 years and a mean follow-up period of 182.4 \u00b1 97.5 days. The dural defects reconstructed were as large as 5.5 cm (mean 2.49 \u00b1 1.36 cm). One patient (3.3%) had a CSF leak that was managed endoscopically. Two patients had epistaxis that required further care, but there were no complications related to intracranial infections or bleeding. Some minor sinonasal complications occurred.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Skull base endoscopic reconstructive techniques have significantly advanced in the past decade. The use of pedicled mucosal flaps in the reconstruction of large dural defects resulting from an endoscopic transnasal craniotomy permits a robust repair. The CSF leak rate in this study is comparable to that achieved in open approaches. The ability to manage the skull base defects successfully with this approach greatly increases the utility of transnasal endoscopic surgery.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.8.jns08236","type":"journal-article","created":{"date-parts":[[2008,12,5]],"date-time":"2008-12-05T15:36:49Z","timestamp":1228491409000},"page":"371-379","source":"Crossref","is-referenced-by-count":76,"title":["Closure of large skull base defects after endoscopic transnasal craniotomy"],"prefix":"10.3171","volume":"111","author":[{"given":"Richard J.","family":"Harvey","sequence":"first","affiliation":[{"name":"Department of Otolaryngology, Skull Base Surgery, Hospital Prof. Edmundo Vasconcelos, Sao Paulo, Brazil;"},{"name":"Department of Rhinology and Neurosurgery, Medical University of South Carolina, Charleston, South Carolina; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jo\u00e3o F.","family":"Nogueira","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Skull Base Surgery, Hospital Prof. Edmundo Vasconcelos, Sao Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rodney J.","family":"Schlosser","sequence":"additional","affiliation":[{"name":"Department of Rhinology and Neurosurgery, Medical University of South Carolina, Charleston, South Carolina; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sunil J.","family":"Patel","sequence":"additional","affiliation":[{"name":"Department of Rhinology and Neurosurgery, Medical University of South Carolina, Charleston, South Carolina; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Vellutini","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Hospital Oswaldo Cruz, Sao Paulo, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aldo C.","family":"Stamm","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, Skull Base Surgery, Hospital Prof. Edmundo Vasconcelos, Sao Paulo, Brazil;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1110371","series-title":"Otolaryngol Head Neck Surg","first-page":"35","article-title":"Significance of MRI changes after surgery of the skull base","volume":"109","author":"Anand","year":"1993"},{"key":"b2-1110371","series-title":"J Neurosurg","first-page":"1055","article-title":"Size-adjustable titanium plate for reconstruction of the sella turcica. 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