{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,1]],"date-time":"2026-04-01T11:26:22Z","timestamp":1775042782094,"version":"3.50.1"},"reference-count":9,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Patients treated for aneurysmal subarachnoid hemorrhage (SAH) often report a loss of smell. To discriminate between the effects of aneurysmal rupture and treatment, the authors assessed the occurrence of anosmia after clipping and coiling of unruptured aneurysms as well as after the coiling of ruptured aneurysms.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors interviewed patients in whom an unruptured aneurysm was treated by clipping (32 cases) or endovascular coiling (26 cases) as well as patients with SAH who underwent coil therapy (32 cases). A geographically defined subset of 20 patients per group was invited to undergo olfactory testing.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Nine clip-treated patients (28% [95% CI 14\u201347%]) in the unruptured group reported having anosmia, and no coil-treated patient in the unruptured group (95% [CI 0\u201313%]) reported having anosmia; in the SAH group, 7 patients (22% [95% CI 9\u201340%]) reported having anosmia. Anosmia had improved over time in 3 of the clip-treated patients and in all but 1 of the patients with SAH. Examination revealed olfactory disturbance in 13 (65% [95% CI 41\u201385%]) of the clip-treated and 8 (42% [95% CI 20\u201367%]) of the coil-treated patients with unruptured aneurysms, and also in 7 (35% [95% CI 15\u201359%]) coil-treated patients with SAH. In 20 patients who underwent clip therapy for unruptured aneurysms, 19 (95% [95% CI 75\u2013100%]) had olfactory dysfunction on the side ipsilateral to surgery (anosmia reported by 8 of them).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Both clip treatment and SAH contribute to the occurrence of anosmia, with different chances of improvement. Olfactory dysfunction occurs in almost all patients on the side of surgery and can occur subclinically after coil deployment.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.8.jns08761","type":"journal-article","created":{"date-parts":[[2008,12,12]],"date-time":"2008-12-12T16:01:07Z","timestamp":1229097667000},"page":"482-486","source":"Crossref","is-referenced-by-count":22,"title":["Anosmia after endovascular and open surgical treatment of intracranial aneurysms"],"prefix":"10.3171","volume":"110","author":[{"given":"Maaike R.","family":"Moman","sequence":"first","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bon H.","family":"Verweij","sequence":"additional","affiliation":[{"name":"Neurosurgery, Rudolf Magnus Institute of Neuroscience, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Joeri","family":"Buwalda","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology, University Medical Center, Utrecht, The Netherlands"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gabri\u00ebl J. E.","family":"Rinkel","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1100482","series-title":"Minim Invasive Neurosurg","doi-asserted-by":"publisher","first-page":"71","DOI":"10.1055\/s-2008-1052220","article-title":"Postoperative anosmia after anterior communicating artery aneurysms surgery by the pterional approach","volume":"39","author":"Aydin","year":"1996"},{"key":"b2-1100482","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"864","DOI":"10.3171\/jns.1990.72.6.0864","article-title":"Anosmia following operation for cerebral aneurysms in the anterior circulation","volume":"72","author":"Eriksen","year":"1990"},{"key":"b3-1100482","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1097\/00006123-199602000-00017","article-title":"Anosmia after anterior communicating artery aneurysm surgery: comparison between the anterior interhemispheric and basal interhemispheric approaches","volume":"38","author":"Fujiwara","year":"1996"},{"key":"b4-1100482","series-title":"Mov Disord","doi-asserted-by":"publisher","first-page":"839","DOI":"10.1002\/mds.21413","article-title":"Olfactory loss may be a first sign of idiopathic Parkinson's disease","volume":"22","author":"Haehner","year":"2007"},{"key":"b5-1100482","series-title":"Ann Otol Rhinol Laryngol","doi-asserted-by":"publisher","first-page":"976","DOI":"10.1177\/000348940111001015","article-title":"Screening of olfactory function with a four-minute odor identification test: reliability, normative data, and investigations in patients with olfactory loss","volume":"110","author":"Hummel","year":"2001"},{"key":"b6-1100482","series-title":"Acta Otolaryngol","doi-asserted-by":"publisher","first-page":"116","DOI":"10.1080\/00016480410022787","article-title":"Olfactory disorders and their consequences for quality of life","volume":"125","author":"Hummel","year":"2005"},{"key":"b7-1100482","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"482","DOI":"10.1007\/BF01808889","article-title":"Permanent postoperative anosmia: a hitherto undescribed complication following surgery of the posterior cranial fossa in the sitting position","volume":"139","author":"Ramsbacher","year":"1997"},{"key":"b8-1100482","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"342","DOI":"10.3171\/jns.1981.54.3.0342","article-title":"Preservation of the olfactory tract in bifrontal craniotomy for anterior communicating artery aneurysms, and the functional prognosis","volume":"54","author":"Suzuki","year":"1981"},{"key":"b9-1100482","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"918","DOI":"10.1227\/01.neu.0000303187.34308.7b","article-title":"Anosmia after aneurysmal subarachnoid hemorrhage","volume":"61","author":"Wermer","year":"2007"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/110\/3\/article-p482.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/110\/3\/article-p482.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/110\/3\/article-p482.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2022,9,26]],"date-time":"2022-09-26T06:03:27Z","timestamp":1664172207000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/110\/3\/article-p482.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2009,3]]},"references-count":9,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2008.8.jns08761","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,3]]}}}