{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,21]],"date-time":"2026-02-21T20:42:10Z","timestamp":1771706530224,"version":"3.50.1"},"reference-count":22,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Meningiomas of the cerebral convexity are often surgically curable because both the mass and involved dura mater can be removed. Stereotactic radiosurgery has become an important primary or adjuvant treatment for patients with intracranial meningiomas. The authors evaluated clinical and imaging outcomes in patients with convexity meningiomas after radiosurgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The patient cohort consisted of 125 patients with convexity meningiomas managed using radiosurgery at some point during an 18-year period. The patient series included 76 women, 55 patients who had undergone prior resection, and 6 patients with neurofibromatosis Type 2. Tumors were located in frontal (80 patients), parietal (24 patients), temporal (12 patients), and occipital (9 patients) areas. The WHO tumor grades in patients with prior resections were Grade I in 34 patients, Grade II in 15 patients, and Grade III in 6 patients. Seventy patients underwent primary radiosurgery and therefore had no prior histological tumor diagnosis. The mean tumor volume was 7.6 ml. Radiosurgery was performed using the Leksell Gamma Knife with a mean tumor margin dose of 14.2 Gy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Serial imaging was evaluated in 115 patients (92%). After primary radiosurgery, the tumor control rate was 92%. After adjuvant radiosurgery, the control rate was 97% for Grade I tumors. The actuarial tumor control rates at 3 and 5 years for the entire series were 86.1 \u00b1 3.8% and 71.6 \u00b1 8.6%, respectively. For patients with benign tumors (Grade I) and those without prior surgery, the actuarial tumor control rate was 95.3 \u00b1 2.3% and 85.8 \u00b1 9.3%, respectively. Delayed resection after radiosurgery was performed in 9 patients (7%) at an average of 35 months. No patient developed a subsequent radiation-induced tumor. The overall morbidity rate was 9.6%. Symptomatic peritumoral imaging changes compatible with edema or adverse radiation effects developed in 5%, at a mean of 8 months.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Stereotactic radiosurgery provides satisfactory control rates either after resection or as an alternate to resection, particularly for histologically benign meningiomas. Its role is most valuable for patients whose tumors affect critical neurological regions and who are poor candidates for resection. Both temporary and permanent morbidity are related to brain location and tumor volume.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2008.8.jns17650","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T13:55:56Z","timestamp":1251813356000},"page":"458-463","source":"Crossref","is-referenced-by-count":56,"title":["Stereotactic radiosurgery for convexity meningiomas"],"prefix":"10.3171","volume":"111","author":[{"given":"Douglas","family":"Kondziolka","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Radiation Oncology, University of Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ricky","family":"Madhok","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"L. Dade","family":"Lunsford","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"David","family":"Mathieu","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juan J.","family":"Martin","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Radiation Oncology, University of Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ajay","family":"Niranjan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John C.","family":"Flickinger","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Radiation Oncology, University of Pittsburgh, Pennsylvania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1110458","series-title":"J Neurosurg","first-page":"58","article-title":"Recurrence of intracranial meningiomas: the role played by regional multicentricity","volume":"64","author":"Borovich","year":"1986"},{"key":"b2-1110458","series-title":"J Neurol Neurosurg Psychiatry","first-page":"226","article-title":"Complications after gamma knife radiosurgery for benign meningiomas","volume":"74","author":"Chang","year":"2003"},{"key":"b3-1110458","series-title":"Int J Radiat Oncol Biol Phys","first-page":"427","article-title":"Benign meningiomas: primary treatment selection affects survival","volume":"39","author":"Condra","year":"1997"},{"key":"b4-1110458","series-title":"Meningiomas. Their Classification, Regional Behaviour, Life History, and Surgical End Results","author":"Cushing","year":"1938"},{"key":"b5-1110458","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1515","article-title":"Factors predicting local tumor control after gamma knife stereotactic radiosurgery for benign intracranial meningiomas","volume":"60","author":"DiBiase","year":"2004"},{"key":"b6-1110458","series-title":"Int J Radiat Oncol Biol Phys","first-page":"801","article-title":"Gamma knife radiosurgery of imaging-defined intracranial meningioma","volume":"56","author":"Flickinger","year":"2003"},{"key":"b7-1110458","series-title":"J Neurosurg","first-page":"206","article-title":"Linear accelerator surgery for meningiomas","volume":"103","author":"Friedman","year":"2005"},{"key":"b8-1110458","series-title":"Surg Neurol","first-page":"588","article-title":"Late outcome of operations for supratentorial convexity meningiomas. Report on 207 cases","volume":"22","author":"Giombini","year":"1984"},{"key":"b9-1110458","series-title":"Neurosurgery","first-page":"446","article-title":"Results of linear accelerator-based radiosurgery for intracranial meningiomas","volume":"42","author":"Hakim","year":"1998"},{"key":"b10-1110458","series-title":"Neurosurgery","first-page":"567","article-title":"Long-term outcome and growth rate of subtotally resected petroclival meningiomas: experience with 38 cases","volume":"46","author":"Jung","year":"2000"},{"key":"b11-1110458","series-title":"Surg Neurol","first-page":"325","article-title":"Long-term results of stereotactic gamma knife radiosurgery of meningiomas","volume":"55","author":"Kobayashi","year":"2001"},{"key":"b12-1110458","series-title":"Neurosurgery","first-page":"405","article-title":"Judicious resection and\/or radiosurgery for parasagittal meningiomas: outcomes from the Gamma knife meningioma study group","volume":"43","author":"Kondziolka","year":"1998"},{"key":"b13-1110458","series-title":"J Neurosurg","first-page":"44","article-title":"Long-term outcomes after meningioma radiosurgery: physicians and patients perspective","volume":"91","author":"Kondziolka","year":"1999"},{"key":"b14-1110458","series-title":"J Neurosurg","first-page":"552","article-title":"Stereotactic radiosurgery of meningiomas","volume":"74","author":"Kondziolka","year":"1991"},{"key":"b15-1110458","series-title":"Neurosurg","first-page":"53","article-title":"Radiosurgery as definitive management of intracranial meningiomas","volume":"62","author":"Kondziolka","year":"2008"},{"key":"b16-1110458","series-title":"Neurosurgery","first-page":"815","article-title":"Long-term results after radiosurgery for benign intracranial tumors","volume":"53","author":"Kondziolka","year":"2003"},{"key":"b17-1110458","series-title":"J Neurosurg","first-page":"187","article-title":"Contemporary management of meningiomas: radiation therapy as an adjuvant and radiosurgery as an alternative to surgical removal?","volume":"80","author":"Lunsford","year":"1994"},{"key":"b18-1110458","series-title":"Acta Neurochir (Wien)","first-page":"53","article-title":"Intracranial meningiomas: analysis of recurrence after surgical treatment","volume":"126","author":"Mahmood","year":"1994"},{"key":"b19-1110458","series-title":"Acta Neurochir (Wien)","first-page":"108","article-title":"Factors influencing meningioma recurrence rate","volume":"107","author":"Naumann","year":"1990"},{"key":"b20-1110458","series-title":"J Neurosurg","first-page":"191","article-title":"Meningiomas: a quest for the optimum therapy","volume":"80","author":"Newman","year":"1994"},{"key":"b21-1110458","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1000","article-title":"Stereotactic radiosurgery provides equivalent tumor control to Simpson Grade 1 resection for patients with small to medium size meningiomas","volume":"55","author":"Pollock","year":"2003"},{"key":"b22-1110458","series-title":"J Neurol Neurosurg Psychiatry","first-page":"22","article-title":"The recurrence of intracranial meningiomas after surgical treatment","volume":"20","author":"Simpson","year":"1957"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/3\/article-p458.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/3\/article-p458.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/3\/article-p458.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T09:36:31Z","timestamp":1679909791000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/3\/article-p458.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2009,9]]},"references-count":22,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2008.8.jns17650","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,9]]}}}