{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T00:36:12Z","timestamp":1791333372001,"version":"4.3.1"},"reference-count":82,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2009,4]]},"abstract":"<jats:p>Moyamoya disease is characterized by a chronic stenoocclusive vasculopathy affecting the terminal internal carotid arteries. The clinical presentation and outcome of moyamoya disease remain varied based on angiographic studies alone, and much work has been done to study cerebral hemodynamics in this group of patients. The ability to measure cerebral blood flow (CBF) accurately continues to improve with time, and with it a better understanding of the pathophysiological mechanisms in patients with moyamoya disease. The main imaging techniques used to evaluate cerebral hemodynamics include PET, SPECT, xenon-enhanced CT, dynamic perfusion CT, MR imaging with dynamic susceptibility contrast and with arterial spin labeling, and Doppler ultrasonography. More invasive techniques include intraoperative ultrasonography. The authors review the current knowledge of CBF in this group of patients and the role each main quantitative method has played in evaluating them, both in the disease state and after surgical intervention.<\/jats:p>","DOI":"10.3171\/2009.1.focus08300","type":"journal-article","created":{"date-parts":[[2009,3,31]],"date-time":"2009-03-31T12:12:42Z","timestamp":1238501562000},"page":"E5","source":"Crossref","is-referenced-by-count":166,"title":["Quantitative hemodynamic studies in moyamoya disease"],"prefix":"10.3171","volume":"26","author":[{"given":"Marco","family":"Lee","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Stanford Stroke Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Greg","family":"Zaharchuk","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Raphael","family":"Guzman","sequence":"additional","affiliation":[{"name":"Department of Radiology, Stanford University, Stanford, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Achal","family":"Achrol","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Stroke Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Teresa","family":"Bell-Stephens","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Stroke Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gary K.","family":"Steinberg","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Stanford Stroke Center; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"1 Suppl","key":"b1-0260005","series-title":"Surg Neurol","first-page":"S4","article-title":"Flow-assisted surgical technique in cerebrovascular surgery","volume":"68","author":"Amin-Hanjani","year":"2007"},{"key":"b2-0260005","series-title":"Brain","first-page":"595","article-title":"Variability of cerebral blood volume and oxygen extraction: stages of cerebral haemodynamic impairment revisited","volume":"125","author":"Derdeyn","year":"2002"},{"key":"b3-0260005","series-title":"Magn Reson Med","first-page":"389","article-title":"Measurement of regional cerebral blood flow in cat brain using intracarotid 2H2O and 2H NMR imaging","volume":"14","author":"Detre","year":"1990"},{"key":"b4-0260005","series-title":"Stroke","first-page":"559","article-title":"Dr C. 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