{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:22:31Z","timestamp":1794324151246,"version":"4.9.0"},"reference-count":18,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2009,5]]},"abstract":"<jats:p>Cobb syndrome is a rare clinical entity that includes the combination of a vascular skin nevus and an angioma in the spinal canal present at identical dermatomal level(s) (cutaneomeningospinal angiomatosis). To date, 38 cases have been reported, only 18 of which are in adults (&gt; 18 years of age). The majority of these cases have been described in the era predating current neuroimaging techniques, and most authors have assumed that each case involves similar vascular pathology. This report highlights 2 patients presenting with similar thoracic cutaneous vascular nevi yet with markedly differing spinal vascular pathology.<\/jats:p>\n                  <jats:p>A 29-year-old man presented with cutaneous hemangioma and a progressive paraparesis and paresthesia of the lower extremities. A 20 \u00d7 20\u2013cm port-wine stain over his right upper midback (T6\u201310) correlated precisely with MR imaging that demonstrated an enhancing epidural mass between T-6 and T-10 causing compression of the cord and cord edema. A 34-year-old man also presented with progressive myelopathy and a 15 \u00d7 20\u2013cm port-wine stain within the same dermatomal region as a Type III spinal arteriovenous malformation.<\/jats:p>\n                  <jats:p>Workup for each patient included pre- and postoperative contrast-enhanced MR imaging with vascular sequencing and spinal angiography. The first patient was treated with bilateral laminectomy at the T6\u201310 levels, with significant postoperative improvement in motor strength. The second patient underwent coil embolization of an intranidal aneurysm, with follow-up embolization 8 years later.<\/jats:p>\n                  <jats:p>Cobb syndrome is an unusual entity in the adult population and should be considered when there is a constellation of cutaneous manifestation and underlying neurological deficit. The vascular skin nevus associated with Cobb syndrome is accompanied by a wide variety of vascular pathologies.<\/jats:p>","DOI":"10.3171\/2009.1.spine08334","type":"journal-article","created":{"date-parts":[[2009,9,28]],"date-time":"2009-09-28T18:26:29Z","timestamp":1254162389000},"page":"430-435","source":"Crossref","is-referenced-by-count":29,"title":["Variety of spinal vascular pathology seen in adult Cobb syndrome"],"prefix":"10.3171","volume":"10","author":[{"given":"Walter D.","family":"Johnson","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelle M.","family":"Petrie","sequence":"additional","affiliation":[{"name":"Anesthesiology, Loma Linda University, Loma Linda, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0100430","series-title":"J Assoc Physicians India","first-page":"846","article-title":"Cobb syndrome","volume":"44","author":"Basappa","year":"1996"},{"key":"b2-0100430","series-title":"ein Fall von Multiplen Angio-lipomen kombiniert mit einen Angioma des R\u00fcckenmarkes","first-page":"24","author":"Berenbruch","year":"1890"},{"key":"b3-0100430","series-title":"Ann Surg","doi-asserted-by":"publisher","first-page":"641","DOI":"10.1097\/00000658-191512000-00001","article-title":"Haemangioma of the spinal cord associated with skin naevi of the same metamere","volume":"62","author":"Cobb","year":"1915"},{"key":"b4-0100430","series-title":"Arch Neurol Psychiat","doi-asserted-by":"publisher","first-page":"359","DOI":"10.1001\/archneurpsyc.1947.02300320110008","article-title":"Subarachnoid cervical angioma with cutaneous hemangioma of a corresponding metamere: report of a case and review of the literature","volume":"58","author":"Cross","year":"1947"},{"key":"b5-0100430","series-title":"N Engl J Med","doi-asserted-by":"publisher","first-page":"1440","DOI":"10.1056\/NEJM196912252812602","article-title":"Value of cutaneous angiomas in the arteriographic localization of spinal-cord arteriovenous malformations","volume":"281","author":"Doppman","year":"1969"},{"key":"b6-0100430","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"546","DOI":"10.3171\/jns.1961.18.4.0546","article-title":"Angioma Racemosum venosum of spinal cord with segmentally related angiomatous lesions of the skin and forearm","volume":"18","author":"Fine","year":"1961"},{"key":"b7-0100430","series-title":"Cervello","first-page":"81","article-title":"L'angiomatosi del midollo spinale","volume":"23","author":"Fracasso","year":"1947"},{"key":"b8-0100430","series-title":"Rinsho Shinkeigaku","first-page":"275","article-title":"[Cobb syndrome and Klippel-Trenaunay-Weber syndrome.]","volume":"31","author":"Fukutake","year":"1991"},{"key":"b9-0100430","series-title":"Contribution \u00e0 l'\u00e9tude des formations vasculaires pathologiques vertebrom\u00e9dullaires (angiomes vert\u00e9braux, \u00e9piduraux, intra-duraux)","author":"Ginsbourg","year":"1960"},{"key":"b10-0100430","series-title":"Acta Neurol Latinoam","first-page":"99","article-title":"Report of a new case of Cobb syndrome. 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The first case reported in Japan.]","volume":"78","author":"Kaito","year":"1989"},{"key":"b13-0100430","series-title":"Handbook of Clinical Neurology","first-page":"429","article-title":"Cobb's Syndrome: cutaneomeningospinal angiomatosis","volume":"14","author":"Kissel","year":"1972"},{"key":"b14-0100430","series-title":"Eur Neurol","doi-asserted-by":"publisher","first-page":"170","DOI":"10.1159\/000008044","article-title":"Simultaneous medullar and cutaneous revelation of a cutaneomeningospinal angiomatosis","volume":"41","author":"Krolak-Salmon","year":"1999"},{"key":"b15-0100430","series-title":"Bull Los Angeles Neurol Soc","first-page":"97","article-title":"Telangiectasis of skin and spinal cord","volume":"23","author":"Nielsen","year":"1958"},{"key":"b16-0100430","series-title":"Dermatology","doi-asserted-by":"publisher","first-page":"45","DOI":"10.1159\/000246199","article-title":"A case of Cobb's Syndrome associated with lymphangioma circumscriptum","volume":"193","author":"Shim","year":"1996"},{"key":"b17-0100430","series-title":"Br J Surg","first-page":"307","article-title":"Vascular tumors of the spinal cord associated with skin haemangiomata","volume":"33","author":"Silverman","year":"1946"},{"key":"b18-0100430","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"199","DOI":"10.3171\/jns.1968.29.2.0199","article-title":"Metameric spinal cord and skin hemangiomas","volume":"29","author":"Szojchet","year":"1968"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/10\/5\/article-p430.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/10\/5\/article-p430.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/10\/5\/article-p430.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T17:19:20Z","timestamp":1681579160000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/10\/5\/article-p430.xml"}},"subtitle":["Report of 2 cases"],"short-title":[],"issued":{"date-parts":[[2009,5]]},"references-count":18,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2009.1.spine08334","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2009,5]]}}}