{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:01:54Z","timestamp":1787025714130,"version":"build-2736575974"},"reference-count":74,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:p>\n                    Vestibular schwannomas (VSs) are benign tumors arising from the sheath of cranial nerve VIII. The pathogenesis underlying most familial and sporadic VSs has been linked to a mutation in a single gene, the\n                    <jats:italic>neurofibromin 2<\/jats:italic>\n                    (\n                    <jats:italic>NF2<\/jats:italic>\n                    ) gene located on chromosome 22, band q11\u201313.1. In this review, the authors summarized what is known about the epidemiology of\n                    <jats:italic>NF2<\/jats:italic>\n                    mutations and patients with VSs. The authors also discuss the function of the\n                    <jats:italic>NF2<\/jats:italic>\n                    gene product, merlin, and describe the known and hypothetical effects of genetic mutations that lead to merlin dysfunction on a broad variety of cellular and histological end points. A better understanding of the molecular pathobiology of VSs may lead to novel therapeutics to augment current modalities of treatment while minimizing morbidity.\n                  <\/jats:p>","DOI":"10.3171\/2009.10.jns091135","type":"journal-article","created":{"date-parts":[[2009,11,27]],"date-time":"2009-11-27T21:57:02Z","timestamp":1259359022000},"page":"359-366","source":"Crossref","is-referenced-by-count":34,"title":["Molecular biology of familial and sporadic vestibular schwannomas: implications for novel therapeutics"],"prefix":"10.3171","volume":"114","author":[{"given":"Michael E.","family":"Sughrue","sequence":"first","affiliation":[{"name":"Neurological Surgery, University of California at San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrea H.","family":"Yeung","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of California at San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology-Head and Neck Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Parsa","sequence":"additional","affiliation":[{"name":"Neurological Surgery, University of California at San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns091135","series-title":"Laryngoscope","first-page":"694","article-title":"Growth rate characteristics of acoustic neuromas associated with neurofibromatosis type 2","volume":"106","author":"Abaza","year":"1996"},{"key":"b2-jns091135","series-title":"Neurosurgery","first-page":"434","article-title":"Human acoustic neuromas secrete interleukin-6 in cell culture: possible autocrine regulation of cell proliferation","volume":"35","author":"Adams","year":"1994"},{"key":"b3-jns091135","series-title":"Curr Opin Neurol","first-page":"27","article-title":"Neurofibromatosis 2","volume":"16","author":"Baser","year":"2003"},{"key":"b4-jns091135","series-title":"Mol Cell Biol","first-page":"1150","article-title":"The neurofibromatosis type 2 gene product, merlin, reverses the F-actin cytoskeletal defects in primary human Schwannoma cells","volume":"22","author":"Bashour","year":"2002"},{"key":"b5-jns091135","series-title":"Otolaryngol Head Neck Surg","first-page":"1","article-title":"Germline screening of the NF-2 gene in families with unilateral vestibular schwannoma","volume":"119","author":"Bikhazi","year":"1998"},{"key":"b6-jns091135","series-title":"Nat Rev Mol Cell Biol","first-page":"586","article-title":"ERM proteins and merlin: integrators at the cell cortex","volume":"3","author":"Bretscher","year":"2002"},{"key":"b7-jns091135","series-title":"Hum Mol Genet","first-page":"271","article-title":"High resolution deletion analysis of constitutional DNA from neurofibromatosis type 2 (NF2) patients using microarray-CGH","volume":"10","author":"Bruder","year":"2001"},{"key":"b8-jns091135","series-title":"Am J Otol","first-page":"65","article-title":"Transforming growth factor-beta1 expression in human acoustic neuroma","volume":"20","author":"Cardillo","year":"1999"},{"key":"b9-jns091135","series-title":"Laryngoscope","first-page":"2129","article-title":"Immunohistochemical demonstration of vascular endothelial growth factor in vestibular schwannomas correlates to tumor growth rate","volume":"113","author":"Cay\u00e9-Thomasen","year":"2003"},{"key":"b10-jns091135","series-title":"Am J Otol","first-page":"301","article-title":"Growth of vestibular schwannomas: in situ model employing the monoclonal antibody Ki-67 and DNA flow cytometry","volume":"17","author":"Charabi","year":"1996"},{"key":"b11-jns091135","series-title":"Trends Biochem Sci","first-page":"281","article-title":"The FERM domain: a unique module involved in the linkage of cytoplasmic proteins to the membrane","volume":"23","author":"Chishti","year":"1998"},{"key":"b12-jns091135","series-title":"Otol Neurotol","first-page":"359","article-title":"Co-expression of transforming growth factor-beta1 and glial cell line-derived neurotrophic factor in vestibular schwannoma","volume":"25","author":"Diensthuber","year":"2004"},{"key":"b13-jns091135","series-title":"J Med Genet","first-page":"847","article-title":"A genetic study of type 2 neurofibromatosis in the United Kingdom. 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