{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T11:07:18Z","timestamp":1694344038821},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2010,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Both CT and high-frequency ultrasound have been shown to be reliable diagnostic tools used to differentiate normal cranial sutures from suture synostosis. In nonsynostotic plagiocephaly, overlapping of the bony plates and the so-called \u201csticky suture\u201d is still controversial and is believed to represent a pathological fusion process. Synchrotron\u2013microcomputed tomography (SRmCT) studies were undertaken to determine whether positional head deformities can be assumed to be true suture pathologies.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Morphological features and growth development of 6 normal cranial sutures between the ages of 3 and 12 months were analyzed histologically. Additionally 6 pathological sutures, including sagittal synostosis and nonsynostotic plagiocephaly (NSP), were compared with the group of normal sutures by histological and SRmCT studies. Synchrotron-microcomputed tomography is a special synchrotron radiation source with a high photon flux providing a monochromatic x-ray beam with a very high spatial resolution. Morphological characteristics of the different suture types were evaluated and bone density alongside the sutures was measured to compare the osseous structure of the adjacent bony plates of normal and pathological sutures.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Histologically jointlike osseous edges of the normal sutures were seen in the 1st month of life and interlocking at the age of approximately 12 months. During this 1st year, bone thickness increases and suture width decreases. The SRmCT studies showed that: 1) sutures and adjacent bones in NSP are comparable to normal sutures in terms of their morphological aspects; 2) bone densities in the adjacent bony plates of NSP and normal sutures are not different; 3) thickening of the diploe with ridging of the bone in sagittal synostosis is associated with significantly higher bone density; 4) synostotic sutures are only partially fused but vary in their extent; and 5) nonfused sections in sagittal synostosis behave like normal sutures without any signs of pathological bone formation.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Sutures in patients with NSP were found without any morphological irregularities or different osseous structures alongside those compared with normal sutures. Thus, a true suture pathology or osseous change of the adjacent bony plates is highly unlikely in NSP. Even though the number of specimens is limited in this series, cranial suture fusion seems to start at one undetermined point and spread along the suture, whereas other parts of the same suture are not involved according to morphological aspects and bone density measurements of the adjacent bones. This theory may represent a dynamic fusion process completed over time but just starting too early.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2009.10.peds09138","type":"journal-article","created":{"date-parts":[[2010,3,1]],"date-time":"2010-03-01T15:04:10Z","timestamp":1267455850000},"page":"238-242","source":"Crossref","is-referenced-by-count":7,"title":["Synchrotron\u2013microcomputed tomography studies of normal and pathological cranial sutures: further insight"],"prefix":"10.3171","volume":"5","author":[{"given":"Jan","family":"Regelsberger","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Schmidt","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bj\u00f6rn","family":"Busse","sequence":"additional","affiliation":[{"name":"Center for Biomechanics and Skeletal Biology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julia","family":"Herzen","sequence":"additional","affiliation":[{"name":"Institute of Materials Research, GKSS Research Centre, Geesthacht, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Tsokos","sequence":"additional","affiliation":[{"name":"Department of Forensic Medicine, University Hospital Hamburg-Eppendorf, Hamburg; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael","family":"Amling","sequence":"additional","affiliation":[{"name":"Center for Biomechanics and Skeletal Biology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Felix","family":"Beckmann","sequence":"additional","affiliation":[{"name":"Institute of Materials Research, GKSS Research Centre, Geesthacht, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0050238","series-title":"Pediatrics","first-page":"1245","article-title":"American Academy of Pediatrics Task Force on Sudden Infant Death Syndrome: the changing concept of sudden infant death syndrome: diagnostic coding shifts, controversies regarding the sleeping environment, and new variables to consider in reducing risk","volume":"116","year":"2005"},{"key":"b2-0050238","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"5","DOI":"10.1097\/00001665-199601000-00005","article-title":"An increase in infant cranial deformity with supine sleeping position","volume":"7","author":"Argenta","year":"1996"},{"issue":"1 Suppl","key":"b3-0050238","series-title":"J Neurosurg","first-page":"16","article-title":"Nonsynostotic scaphocephaly: the socalled sticky sagittal suture","volume":"101","author":"Baumgartner","year":"2004"},{"key":"b4-0050238","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"2416","DOI":"10.1097\/00006534-200006000-00017","article-title":"Growth restriction of cranial sutures in the fetal lamb causes deformational changes, not craniosynostosis","volume":"105","author":"Bradley","year":"2000"},{"key":"b5-0050238","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"21","DOI":"10.1097\/00006534-199289010-00005","article-title":"Frontal plagiocephaly: synostotic, compensational, or deformational","volume":"89","author":"Bruneteau","year":"1992"},{"key":"b6-0050238","series-title":"Am J Med Genet","doi-asserted-by":"publisher","first-page":"581","DOI":"10.1002\/ajmg.1320470507","article-title":"Sutural biology and the correlates of craniosynostosis","volume":"47","author":"Cohen","year":"1993"},{"key":"b7-0050238","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"720","DOI":"10.1007\/BF00366157","article-title":"Lambdoid stenosis (posterior plagiocephaly) and craniofacial asymmetry: long-term outcomes","volume":"12","author":"Goodrich","year":"1996"},{"key":"b8-0050238","series-title":"Cleft Palate Craniofac J","doi-asserted-by":"publisher","first-page":"204","DOI":"10.1597\/1545-1569_1998_035_0204_tddoah_2.3.co_2","article-title":"The differential diagnosis of abnormal head shapes: separating craniosynostosis from positional deformities and normal variants","volume":"35","author":"Huang","year":"1998"},{"key":"b9-0050238","series-title":"Plast Reconstr Surg","first-page":"1860","article-title":"Nonsynostotic occipital plagiocephaly: radiographic diagnosis of the \u201csticky suture.\u201d","volume":"116","author":"Losee","year":"2005"},{"key":"b10-0050238","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1007\/s00381-005-1233-2","article-title":"Positional skull deformities in children: skull deformation without synostosis","volume":"22","author":"Mart\u00ednez-Lage","year":"2006"},{"key":"b11-0050238","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"667","DOI":"10.3171\/jns.1997.87.5.0667","article-title":"Nonsurgical, nonorthotic treatment of occipital plagiocephaly: what is the natural history of the misshapen neonatal head?","volume":"87","author":"Moss","year":"1997"},{"key":"b12-0050238","series-title":"Plast Reconstr Surg","doi-asserted-by":"publisher","first-page":"371","DOI":"10.1097\/00006534-199902000-00003","article-title":"Analysis of posterior plagiocephaly: deformational versus synostotic","volume":"103","author":"Mulliken","year":"1999"},{"key":"b13-0050238","series-title":"Pediatrics","first-page":"199","article-title":"Prevention and management of positional skull deformities in infants. American Academy of Pediatrics Committee on Practice and Ambulatory Medicine, Section on Plastic Surgery and Section on Neurological Surgery","volume":"112","author":"Persing","year":"2003"},{"key":"b14-0050238","series-title":"J Craniofac Surg","doi-asserted-by":"publisher","first-page":"623","DOI":"10.1097\/00001665-200607000-00002","article-title":"Ultrasound in the diagnosis of craniosynostosis","volume":"17","author":"Regelsberger","year":"2006"},{"issue":"5 Suppl","key":"b15-0050238","series-title":"J Neurosurg","first-page":"413","article-title":"High-frequency ultrasound confirmation of positional plagiocephaly","volume":"105","author":"Regelsberger","year":"2006"},{"key":"b16-0050238","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"24","DOI":"10.3171\/jns.1998.89.1.0024","article-title":"Occipital plagiocephaly: a critical review of the literature","volume":"89","author":"Rekate","year":"1998"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/5\/3\/article-p238.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/5\/3\/article-p238.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/5\/3\/article-p238.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:41:48Z","timestamp":1681562508000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/5\/3\/article-p238.xml"}},"subtitle":["Laboratory investigation"],"short-title":[],"issued":{"date-parts":[[2010,3]]},"references-count":16,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2009.10.peds09138","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,3]]}}}