{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T12:10:38Z","timestamp":1783080638036,"version":"3.54.6"},"reference-count":66,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Pineocytoma is a rare tumor, and the current literature on these tumors is primarily composed of case reports and small case series. Thus, recommendations on appropriate treatment of these tumors are highly varied. Therefore, the authors performed a systematic review of the literature on tumor control after surgery for pineocytoma to determine the relative benefits of aggressive resection and postoperative adjuvant radiotherapy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A comprehensive search of the published English-language literature was performed to identify studies citing outcome data of patients undergoing surgery for pineocytoma. Determination of rates of progression-free survival (PFS) was performed using Kaplan-Meier analysis.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Sixty-four articles met the criteria of the established search protocol, which combined for a total of 166 patients. Twenty-one percent of these patients had undergone a biopsy procedure, 38% had undergone subtotal resection (STR), 42% had undergone gross-total resection, and 28% were treated with radiation therapy. The 1- and 5-year PFS rates for the resection group versus the biopsy group were 97 and 90% (1 year), and 89 and 75% (5 years), respectively (p &lt; 0.05, log-rank test). The 1- and 5-year PFS rates for the GTR group versus the group undergoing STR combined with radiation therapy were 100 and 94% (1 year), and 100 and 84% (5 years), respectively (p &lt; 0.05, log-rank test). There was no significant difference in PFS for STR only compared with STR in addition to radiation therapy.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Gross-total resection is the ideal treatment for pineocytoma and might represent a cure for these lesions. When gross-total resection is not possible, adjuvant radiation therapy after STR is of questionable benefit for these patients.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2009.12.jns091683","type":"journal-article","created":{"date-parts":[[2010,2,5]],"date-time":"2010-02-05T15:06:57Z","timestamp":1265382417000},"page":"319-324","source":"Crossref","is-referenced-by-count":44,"title":["Tumor control after surgery and radiotherapy for pineocytoma"],"prefix":"10.3171","volume":"113","author":[{"given":"Aaron J.","family":"Clark","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Ivan","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael E.","family":"Sughrue","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Yang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Aranda","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Seunggu J.","family":"Han","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ari J.","family":"Kane","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Parsa","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl","key":"b1-jns091683","series-title":"J Neurosurg","first-page":"175","article-title":"Pineal tumors: analysis of treatment results in 20 patients","volume":"102","author":"Amendola","year":"2005"},{"key":"b2-jns091683","series-title":"N Engl J Med","first-page":"542","article-title":"Case records of the Massachusetts General Hospital. Weekly clinicopathological exercises. Case 35\u20131983. A 25-year-old woman with increasingly frequent headaches","volume":"309","author":"Anonymous","year":"1983"},{"key":"b3-jns091683","series-title":"Neurosurgery","first-page":"1022","article-title":"Surgery of the Soul's cistern","volume":"39","author":"Apuzzo","year":"1996"},{"key":"b4-jns091683","series-title":"BMJ","first-page":"328","article-title":"Melatonin as a tumour marker in a patient with pineal tumour","volume":"2","author":"Barber","year":"1978"},{"key":"b5-jns091683","series-title":"Dev Med Child Neurol","first-page":"816","article-title":"Serial neuropsychological follow-up of a child following craniospinal irradiation","volume":"30","author":"Bendersky","year":"1988"},{"key":"b6-jns091683","series-title":"Cancer","first-page":"1408","article-title":"The separation of pineocytoma from pineoblastoma","volume":"45","author":"Borit","year":"1980"},{"key":"b7-jns091683","series-title":"Cancer","first-page":"1353","article-title":"Pineocytomas of childhood. A reappraisal of natural history and response to therapy","volume":"59","author":"D'Andrea","year":"1987"},{"key":"b8-jns091683","series-title":"J Neurooncol","first-page":"131","article-title":"Cytogenetic and ultrastructural study of a pineocytoma case report","volume":"48","author":"Dario","year":"2000"},{"key":"b9-jns091683","series-title":"Acta Neurochir (Wien)","first-page":"14","article-title":"Stereotactic diagnosis and treatment of pineal region tumours and vascular malformations","volume":"116","author":"Dempsey","year":"1992"},{"key":"b10-jns091683","series-title":"Neurosurgery","first-page":"349","article-title":"Diagnosis and management of pineocytomas","volume":"55","author":"Deshmukh","year":"2004"},{"key":"b11-jns091683","series-title":"Cancer","first-page":"302","article-title":"Pineocytomas","volume":"63","author":"Disclafani","year":"1989"},{"key":"b12-jns091683","series-title":"Neuroradiology","first-page":"399","article-title":"Cystic lesions of the pineal region\u2014MRI and pathology","volume":"42","author":"Engel","year":"2000"},{"key":"b13-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"63","article-title":"Pineocytoma with neuronal differentiation\u2014case report","volume":"30","author":"Fukushima","year":"1990"},{"key":"b14-jns091683","series-title":"Radiother Oncol","first-page":"31","article-title":"Radiotherapy for tumours of the pineal region and suprasellar germinomas","volume":"16","author":"Glanzmann","year":"1989"},{"key":"b15-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"836","article-title":"Pineocytoma with intratumoral hemorrhage following ventriculoperitoneal shunt\u2014case report","volume":"33","author":"Harada","year":"1993"},{"key":"b16-jns091683","series-title":"Neurosurgery","first-page":"880","article-title":"The role of radiosurgery for the treatment of pineal parenchymal tumors","volume":"51","author":"Hasegawa","year":"2002"},{"key":"b17-jns091683","series-title":"Surg Neurol","first-page":"381","article-title":"Multiple distinct intracranial tumors: association of pinealoma and craniopharyngioma. Case report","volume":"31","author":"Hazen","year":"1989"},{"key":"b18-jns091683","series-title":"Brain","first-page":"289","article-title":"The cytological differentiating potential of pineal parenchymal neoplasms (true pinealomas). A clinicopathological study of 28 tumours","volume":"102","author":"Herrick","year":"1979"},{"key":"b19-jns091683","series-title":"Clin Oncol (R Coll Radiol)","first-page":"238","article-title":"Pineal parenchymal tumours: I. Pineocytoma: a tumour responsive to platinum-based chemotherapy","volume":"16","author":"Jackson","year":"2004"},{"key":"b20-jns091683","series-title":"J Neurosurg","first-page":"654","article-title":"Diagnosis and management of pineal tumors","volume":"58","author":"Jooma","year":"1983"},{"key":"b21-jns091683","series-title":"Brain Pathol","first-page":"49","article-title":"Pineal parenchymal tumors: a correlation of histological features with prognosis in 66 cases","volume":"10","author":"Jouvet","year":"2000"},{"key":"b22-jns091683","series-title":"Surg Neurol","first-page":"383","article-title":"Radiosurgery for bilateral neurinomas associated with neurofibromatosis type 2","volume":"53","author":"Kida","year":"2000"},{"key":"b23-jns091683","series-title":"Pediatr Neurosurg","first-page":"307","article-title":"Pineal tumors and associated lesions: the effect of ethnicity on tumor type and treatment","volume":"38","author":"Knierim","year":"2003"},{"key":"b24-jns091683","series-title":"J Neurooncol","first-page":"301","article-title":"Stereotactic gamma radiosurgery for pineal and related tumors","volume":"54","author":"Kobayashi","year":"2001"},{"key":"b25-jns091683","series-title":"Cancer","first-page":"2119","article-title":"Pathological survey of intracranial germinoma and pinealoma in Japan","volume":"45","author":"Koide","year":"1980"},{"key":"b26-jns091683","series-title":"Childs Nerv Syst","first-page":"564","article-title":"Combination chemotherapy (cisplatin, vinblastin) and low-dose irradiation in the treatment of pineal parenchymal cell tumors","volume":"14","author":"Kurisaka","year":"1998"},{"key":"b27-jns091683","series-title":"Palliat Med","first-page":"255","article-title":"Risperidone: a useful adjunct for behavioural disturbance in primary cerebral tumours","volume":"15","author":"Lee","year":"2001"},{"key":"b28-jns091683","series-title":"J Neurooncol","first-page":"85","article-title":"Pineal tumors","volume":"12","author":"Linggood","year":"1992"},{"key":"b29-jns091683","series-title":"Neurosurgery","first-page":"736","article-title":"Radiosurgery for acoustic neurinomas: early experience","volume":"26","author":"Linskey","year":"1990"},{"key":"b30-jns091683","series-title":"Childs Nerv Syst","first-page":"750","article-title":"Pineal cysts in childhood","volume":"19","author":"Mandera","year":"2003"},{"key":"b31-jns091683","series-title":"Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub","first-page":"121","article-title":"Papillary pineocytoma in child: a case report","volume":"151","author":"Marcol","year":"2007"},{"key":"b32-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"911","article-title":"Pineocytoma with massive intratumoral hemorrhage after ventriculoperitoneal shunt\u2014case report","volume":"37","author":"Matsumoto","year":"1997"},{"key":"b33-jns091683","series-title":"Acta Neurochir (Wien)","first-page":"783","article-title":"Pineal epidermoid coinciding with pineocytoma","volume":"145","author":"Mawrin","year":"2003"},{"key":"b34-jns091683","series-title":"Hum Pathol","first-page":"20","article-title":"Tumors of pineal parenchymal cells: a correlation of histological features, including nucleolar organizer regions, with survival in 35 cases","volume":"26","author":"Mena","year":"1995"},{"key":"b35-jns091683","series-title":"N Engl J Med","first-page":"329","article-title":"Diagnostic potential of melatonin analysis in pineal tumors","volume":"313","author":"Miles","year":"1985"},{"key":"b36-jns091683","series-title":"Acta Neurochir (Wien)","first-page":"154","article-title":"Tinnitus and hearing loss in pineal region tumours","volume":"135","author":"Missori","year":"1995"},{"key":"b37-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"169","article-title":"Cystic pineocytoma\u2014case report","volume":"32","author":"Momozaki","year":"1992"},{"key":"b38-jns091683","series-title":"Am J Ophthalmol","first-page":"810","article-title":"Acquired double elevator palsy in a child with a pineocytoma","volume":"118","author":"Mu\u00f1oz","year":"1994"},{"key":"b39-jns091683","series-title":"AJNR Am J Neuroradiol","first-page":"195","article-title":"MR imaging of pineocytoma: report of two cases","volume":"11","author":"Nakagawa","year":"1990"},{"key":"b40-jns091683","series-title":"Neuroradiology","first-page":"509","article-title":"Neuroradiological characteristics of pineocytoma and pineoblastoma","volume":"42","author":"Nakamura","year":"2000"},{"key":"b41-jns091683","series-title":"Clin Neurosurg","first-page":"397","article-title":"An update on the surgical treatment of malignant pineal region tumors","volume":"32","author":"Neuwelt","year":"1985"},{"key":"b42-jns091683","series-title":"Neurosurgery","first-page":"373","article-title":"Surgical resection of a pineal tumor containing elements of germinoma and astrocytoma","volume":"16","author":"Neuwelt","year":"1985"},{"key":"b43-jns091683","series-title":"J Neurosurg","first-page":"597","article-title":"Malignant pineal region tumors. A clinico-pathological study","volume":"51","author":"Neuwelt","year":"1979"},{"key":"b44-jns091683","series-title":"Childs Nerv Syst","first-page":"355","article-title":"Brain stem necrosis after preradiation high-dose methotrexate","volume":"1","author":"Packer","year":"1985"},{"key":"b45-jns091683","series-title":"Br J Neurosurg","first-page":"305","article-title":"The role of endoscopic biopsy and third ventriculostomy in the management of pineal region tumours","volume":"15","author":"Pople","year":"2001"},{"key":"b46-jns091683","series-title":"South Med J","first-page":"1081","article-title":"Neoplasms of the pineal region","volume":"89","author":"Prahlow","year":"1996"},{"key":"b47-jns091683","series-title":"Cancer Genet Cytogenet","first-page":"127","article-title":"Cytogenetic study of a pineocytoma","volume":"64","author":"Rainho","year":"1992"},{"key":"b48-jns091683","series-title":"Acta Neurochir (Wien)","first-page":"5","article-title":"The role of Gamma Knife radiosurgery in the treatment of pineal parenchymal tumours","volume":"148","author":"Reyns","year":"2006"},{"key":"b49-jns091683","series-title":"J Pathol","first-page":"27","article-title":"Gangliogliomatous differentiation in a pineocytoma","volume":"102","author":"Rubinstein","year":"1970"},{"key":"b50-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"825","article-title":"Responses of pineocytoma to radiation therapy and chemotherapy\u2014report of two cases","volume":"29","author":"Sakoda","year":"1989"},{"key":"b51-jns091683","series-title":"J Neurosurg","first-page":"936","article-title":"Cranial surgery navigation aided by a compact intraoperative magnetic resonance imager","volume":"94","author":"Schulder","year":"2001"},{"key":"b52-jns091683","series-title":"Eur J Pediatr","first-page":"233","article-title":"Pineal region tumours of childhood","volume":"146","author":"Schulte","year":"1987"},{"key":"b53-jns091683","series-title":"Korean J Pathol","first-page":"265","article-title":"Pleomorphic variant of pineocytoma\u2014a case report","volume":"38","author":"Shin","year":"2004"},{"key":"b54-jns091683","series-title":"Acta Neurochir (Wien)","first-page":"801","article-title":"Surgical treatment of pineal region tumours through the occipital transtentorial approach: evaluation of the effectiveness of intra-operative micro-endoscopy combined with neuronavigation","volume":"141","author":"Shirane","year":"1999"},{"key":"b55-jns091683","series-title":"J Neurosurg","first-page":"776","article-title":"Pineocytomas presenting as subarachnoid hemorrhage. Report of two cases","volume":"47","author":"Steinbok","year":"1977"},{"key":"b56-jns091683","series-title":"J Clin Neurosci","first-page":"125","article-title":"Therapeutic strategies and surgical results for pineal region tumours","volume":"7","author":"Tamaki","year":"2000"},{"key":"b57-jns091683","series-title":"Childs Nerv Syst","first-page":"297","article-title":"Radiological and pathological findings in three cases of childhood pineocytomas","volume":"2","author":"Tracy","year":"1986"},{"key":"b58-jns091683","series-title":"Cancer","first-page":"1789","article-title":"Malignant pineocytoma with prominent papillary features","volume":"50","author":"Trojanowski","year":"1982"},{"key":"b59-jns091683","series-title":"Australas Radiol","first-page":"313","article-title":"Tumours of the pineal region\u2014neuroradiological aspects","volume":"21","author":"Tucker","year":"1977"},{"key":"b60-jns091683","series-title":"Neurol Med Chir (Tokyo)","first-page":"1","article-title":"Treatments and prognoses of pineal tumors\u2014experience of 110 cases","volume":"20","author":"Ueki","year":"1980"},{"key":"b61-jns091683","series-title":"J Neurosurg","first-page":"135","article-title":"Papillary pineocytoma. Case report","volume":"73","author":"Vaquero","year":"1990"},{"key":"b62-jns091683","series-title":"Neurosurgery","first-page":"612","article-title":"Clinicopathological experience with pineocytomas: report of five surgically treated cases","volume":"27","author":"Vaquero","year":"1990"},{"key":"b63-jns091683","series-title":"Neuropediatrics","first-page":"222","article-title":"Microsurgery of pineal region lesions in children","volume":"18","author":"Vorkapic","year":"1987"},{"key":"b64-jns091683","series-title":"Neurosurgery","first-page":"817","article-title":"Serum melatonin levels: a new neurodiagnostic tool in pineal region tumors?","volume":"21","author":"Vorkapic","year":"1987"},{"key":"b65-jns091683","series-title":"Comput Radiol","first-page":"285","article-title":"Clinical and computed tomographic correlations of pineal neoplasms","volume":"8","author":"Weisberg","year":"1984"},{"key":"b66-jns091683","series-title":"J Neurosurg","first-page":"1050","article-title":"Combined supra\/infratentorial-transsinus approach to large pineal region tumors","volume":"88","author":"Ziyal","year":"1998"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/2\/article-p319.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/2\/article-p319.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/2\/article-p319.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:14:05Z","timestamp":1679890445000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/2\/article-p319.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2010,8]]},"references-count":66,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2009.12.jns091683","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,8]]}}}