{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,21]],"date-time":"2025-10-21T15:03:31Z","timestamp":1761059011255},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Many patients undergoing carotid endarterectomy (CEA) regularly take clopidogrel, a permanent platelet inhibitor. The authors sought to determine whether taking clopidogrel in the period before CEA leads to more bleeding or other complications.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors performed a retrospective, institutional review board\u2013approved review of 182 consecutive patients who underwent CEA. Clinical, radiographic, and surgical data were gleaned from hospital and clinic records. Analysis was based on the presence or absence of clopidogrel in patients undergoing CEA and was performed twice by considering clopidogrel use within 8 days and within 5 days of surgery to define the groups.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Taking clopidogrel within 8 days before surgery resulted in no statistical increase in any measure of morbidity or death. Taking clopidogrel within 5 days was associated with a small but significant increase in operative blood loss and conservatively managed postoperative neck swelling. No measure of permanent morbidity or death was increased in either clopidogrel group.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Findings in this study support the safety of preoperative clopidogrel in patients undergoing CEA.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2009.12.jns09707","type":"journal-article","created":{"date-parts":[[2010,1,29]],"date-time":"2010-01-29T15:25:50Z","timestamp":1264778750000},"page":"908-912","source":"Crossref","is-referenced-by-count":16,"title":["Safety of carotid endarterectomy while on clopidogrel (Plavix)"],"prefix":"10.3171","volume":"113","author":[{"given":"Scott D.","family":"Wait","sequence":"first","affiliation":[{"name":"Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Adib A.","family":"Abla","sequence":"additional","affiliation":[{"name":"Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brendan D.","family":"Killory","sequence":"additional","affiliation":[{"name":"Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert M.","family":"Starke","sequence":"additional","affiliation":[{"name":"Albert Einstein College of Medicine, Bronx, New York"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert F.","family":"Spetzler","sequence":"additional","affiliation":[{"name":"Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Nakaji","sequence":"additional","affiliation":[{"name":"Division of Neurological Surgery, Barrow Neurological Institute, St. Joseph's Hospital and Medical Center, Phoenix, Arizona; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns09707","series-title":"Ann Thorac Surg","first-page":"1210","article-title":"In-hospital patients exposed to clopidogrel before coronary artery bypass graft surgery: a word of caution","volume":"79","author":"Ascione","year":"2005"},{"key":"b2-jns09707","series-title":"J Intern Med","first-page":"399","article-title":"Low-dose aspirin for secondary cardiovascular prevention\u2014cardiovascular risks after its perioperative withdrawal versus bleeding risks with its continuation\u2014review and meta-analysis","volume":"257","author":"Burger","year":"2005"},{"key":"b3-jns09707","series-title":"Circulation","first-page":"1440","article-title":"Stent thrombosis late after implantation of first-generation drug-eluting stents: a cause for concern","volume":"115","author":"Camenzind","year":"2007"},{"key":"b4-jns09707","series-title":"Br J Anaesth","first-page":"316","article-title":"Perioperative antiplatelet therapy: the case for continuing therapy in patients at risk of myocardial infarction","volume":"99","author":"Chassot","year":"2007"},{"key":"b5-jns09707","series-title":"Best Pract Res Clin Anaesthesiol","first-page":"241","article-title":"Perioperative use of antiplatelet drugs","volume":"21","author":"Chassot","year":"2007"},{"key":"b6-jns09707","series-title":"J Thorac Cardiovasc Surg","first-page":"425","article-title":"Clopidogrel and bleeding in patients undergoing elective coronary artery bypass grafting","volume":"128","author":"Chen","year":"2004"},{"key":"b7-jns09707","series-title":"Ann Thorac Surg","first-page":"1536","article-title":"Does clopidogrel increase blood loss following coronary artery bypass surgery?","volume":"78","author":"Chu","year":"2004"},{"key":"b8-jns09707","series-title":"Eur J Vasc Endovasc Surg","first-page":"135","article-title":"Influence of antiplatelet therapy on cerebral micro-emboli after carotid endarterectomy using postoperative transcranial Doppler monitoring","volume":"34","author":"de Borst","year":"2007"},{"key":"b9-jns09707","series-title":"Eur J Vasc Endovasc Surg","first-page":"41","article-title":"Is heparin reversal with protamine after carotid endarterectomy dangerous?","volume":"36","author":"Dellagrammaticas","year":"2008"},{"key":"b10-jns09707","series-title":"Am Surg","first-page":"111","article-title":"Wound hematomas after carotid endarterectomy","volume":"51","author":"Gomez","year":"1985"},{"key":"b11-jns09707","series-title":"J Am Coll Cardiol","first-page":"231","article-title":"The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting","volume":"40","author":"Hongo","year":"2002"},{"key":"b12-jns09707","series-title":"JAMA","first-page":"2126","article-title":"Incidence, predictors, and outcome of thrombosis after successful implantation of drug-eluting stents","volume":"293","author":"Iakovou","year":"2005"},{"key":"b13-jns09707","series-title":"Eur J Vasc Endovasc Surg","first-page":"312","article-title":"The use of clopidogrel in carotid endarterectomy: an audit of current practice","volume":"34","author":"Jackson","year":"2007"},{"key":"b14-jns09707","series-title":"Circulation","first-page":"1667","article-title":"Effect of clopidogrel premedication in off-pump cardiac surgery: are we forfeiting the benefits of reduced hemorrhagic sequelae?","volume":"113","author":"Kapetanakis","year":"2006"},{"key":"b15-jns09707","series-title":"Eur J Cardiothorac Surg","first-page":"419","article-title":"Clopidogrel does not increase bleeding and allogenic blood transfusion in coronary artery surgery","volume":"25","author":"Karabulut","year":"2004"},{"key":"b16-jns09707","series-title":"Circulation","first-page":"2233","article-title":"Dual antiplatelet therapy with clopidogrel and aspirin in symptomatic carotid stenosis evaluated using doppler embolic signal detection: the Clopidogrel and Aspirin for Reduction of Emboli in Symptomatic Carotid Stenosis (CARESS) trial","volume":"111","author":"Markus","year":"2005"},{"key":"b17-jns09707","series-title":"Biomed Chromatogr","first-page":"26","article-title":"Clopidogrel: review of bioanalytical methods, pharmacokinetics\/pharmacodynamics, and update on recent trends in drug-drug interaction studies","volume":"23","author":"Mullangi","year":"2009"},{"key":"b18-jns09707","series-title":"Stroke","first-page":"2464","article-title":"Therapeutic benefit of low-dose clopidogrel in patients undergoing carotid surgery is linked to variability in the platelet adenosine diphosphate response and patients' weight","volume":"38","author":"Payne","year":"2007"},{"key":"b19-jns09707","series-title":"Circulation","first-page":"1476","article-title":"Beneficial effects of clopidogrel combined with aspirin in reducing cerebral emboli in patients undergoing carotid endarterectomy","volume":"109","author":"Payne","year":"2004"},{"key":"b20-jns09707","series-title":"J Am Coll Cardiol","first-page":"2584","article-title":"Late clinical events after clopidogrel discontinuation may limit the benefit of drug-eluting stents: an observational study of drug-eluting versus baremetal stents","volume":"48","author":"Pfisterer","year":"2006"},{"key":"b21-jns09707","series-title":"Can J Anaesth","first-page":"635","article-title":"Risk factors for post-carotid endarterectomy hematoma formation","volume":"46","author":"Self","year":"1999"},{"key":"b22-jns09707","series-title":"Ann R Coll Surg Engl","first-page":"97","article-title":"Current practice in the use of antiplatelet agents in the peri-operative period by UK vascular surgeons","volume":"85","author":"Smout","year":"2003"},{"key":"b23-jns09707","series-title":"Circulation","first-page":"2803","article-title":"Prevalence, predictors, and outcomes of premature discontinuation of thienopyridine therapy after drug-eluting stent placement: results from the PREMIER registry","volume":"113","author":"Spertus","year":"2006"},{"key":"b24-jns09707","series-title":"Heart Surg Forum","first-page":"282","article-title":"Off-pump coronary artery bypass grafting attenuates postoperative bleeding associated with preoperative clopidogrel administration","volume":"6","author":"Woo","year":"2003"},{"key":"b25-jns09707","series-title":"Crit Care Med","first-page":"2271","article-title":"Effect of clopidogrel on bleeding after coronary artery bypass surgery","volume":"29","author":"Yende","year":"2001"}],"container-title":["Journal of 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article"],"short-title":[],"issued":{"date-parts":[[2010,10]]},"references-count":25,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2009.12.jns09707","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,10]]}}}