{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,4]],"date-time":"2026-10-04T18:53:02Z","timestamp":1791139982752,"version":"4.1.0"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>Optic pathway gliomas (OPGs) arise from the optic nerves, optic chiasm, and\/or hypothalamus and most commonly occur in childhood. Although these tumors can be quite challenging to manage, they are typically low-grade astrocytomas histologically, most commonly pilocytic astrocytomas. The few previously reported cases of malignant degeneration of an OPG occurred after external beam radiation therapy. The authors report the first case in the English literature of an OPG that transformed from a low-grade astrocytoma, with features most consistent with a pilocytic astrocytoma, to a malignant glioma without any exposure to radiation therapy.<\/jats:p>","DOI":"10.3171\/2009.12.peds09173","type":"journal-article","created":{"date-parts":[[2010,4,30]],"date-time":"2010-04-30T14:09:53Z","timestamp":1272636593000},"page":"507-510","source":"Crossref","is-referenced-by-count":28,"title":["Malignant transformation of an optic pathway glioma without prior radiation therapy"],"prefix":"10.3171","volume":"5","author":[{"given":"Garrett K.","family":"Zoeller","sequence":"first","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carole D.","family":"Brathwaite","sequence":"additional","affiliation":[{"name":"Department of Pathology, Miami Children's Hospital, Miami, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David I.","family":"Sandberg","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, University of Miami Miller School of Medicine; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0050507","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1136","DOI":"10.1007\/s00381-006-0086-7","article-title":"Optic pathway glioma: outcome and prognostic factors in a surgical series","volume":"22","author":"Ahn","year":"2006"},{"key":"b2-0050507","series-title":"Brain Pathol","doi-asserted-by":"publisher","first-page":"799","DOI":"10.1111\/j.1750-3639.1997.tb01065.x","article-title":"Optic chiasmatic-hypothalamic glioma","volume":"7","author":"Alshail","year":"1997"},{"key":"b3-0050507","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"787","DOI":"10.1227\/00006123-198212000-00011","article-title":"Malignant optic glioma presenting radiologically as a \u201ccystic\u201d suprasellar mass: case report and review of the literature","volume":"11","author":"Barbaro","year":"1982"},{"key":"b4-0050507","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"470","DOI":"10.3171\/jns.1972.37.4.0470","article-title":"Late malignant recurrence of childhood cerebellar astrocytoma. Report of two cases","volume":"37","author":"Bernell","year":"1972"},{"key":"b5-0050507","series-title":"Acta Radiol","doi-asserted-by":"publisher","first-page":"375","DOI":"10.1080\/028418500127345505","article-title":"Chiasmatic glioblastoma of childhood. A case report","volume":"41","author":"Cirak","year":"2000"},{"key":"b6-0050507","series-title":"J Clin Neurosci","doi-asserted-by":"publisher","first-page":"502","DOI":"10.1016\/j.jocn.2006.04.012","article-title":"Glioblastoma of the optic chiasm","volume":"14","author":"Dinh","year":"2007"},{"key":"b7-0050507","series-title":"Neurosurgery","first-page":"68","article-title":"Development of anaplastic changes in low-grade astrocytomas of childhood","volume":"34","author":"Dirks","year":"1994"},{"key":"b8-0050507","series-title":"Pediatr Blood Cancer","doi-asserted-by":"publisher","first-page":"245","DOI":"10.1002\/pbc.21563","article-title":"Outcome analysis of childhood low-grade astrocytomas","volume":"51","author":"Fisher","year":"2008"},{"key":"b9-0050507","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1937","DOI":"10.1002\/1097-0142(19940401)73:7<1937::AID-CNCR2820730727>3.0.CO;2-G","article-title":"Low grade supratentorial astrocytomas. Management and prognostic factors","volume":"73","author":"Janny","year":"1994"},{"key":"b10-0050507","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1159\/000121218","article-title":"Recurrence patterns and anaplastic change in a long-term study of pilocytic astrocytomas","volume":"27","author":"Krieger","year":"1997"},{"key":"b11-0050507","series-title":"Br J Ophthalmol","doi-asserted-by":"publisher","first-page":"539","DOI":"10.1136\/bjo.60.7.539","article-title":"Recurrence of astrocytoma of optic nerve after 48 years","volume":"60","author":"Mullaney","year":"1976"},{"key":"b12-0050507","series-title":"J Neurosurg","first-page":"898","article-title":"Glioblastoma of the optic chiasm","volume":"84","author":"Pallini","year":"1996"},{"key":"b13-0050507","series-title":"Br J Ophthalmol","doi-asserted-by":"publisher","first-page":"40","DOI":"10.1136\/bjo.2007.125567","article-title":"Juvenile pilocytic astrocytomas do not undergo spontaneous malignant transformation: grounds for designation as hamartomas","volume":"92","author":"Parsa","year":"2008"},{"key":"b14-0050507","series-title":"Pathology of Tumours of the Nervous System","first-page":"105","author":"Russell","year":"1989"},{"key":"b15-0050507","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"9","DOI":"10.3171\/jns.1985.62.1.0009","article-title":"Evolution and outcome in malignant astroglial neoplasms of the cerebellum","volume":"62","author":"Steinberg","year":"1985"},{"key":"b16-0050507","series-title":"Pediatr Neurol","doi-asserted-by":"publisher","first-page":"262","DOI":"10.1016\/S0887-8994(02)00628-8","article-title":"Long-term outcome in children with gliomas of the anterior visual pathway","volume":"28","author":"Tow","year":"2003"},{"key":"b17-0050507","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"251","DOI":"10.1227\/00006123-198708000-00025","article-title":"Malignant recurrence of childhood cerebellar astrocytoma: case report","volume":"21","author":"Ushio","year":"1987"},{"key":"b18-0050507","series-title":"Graefes Arch Clin Exp Ophthalmol","doi-asserted-by":"publisher","first-page":"741","DOI":"10.1007\/s00417-004-0905-z","article-title":"Unilateral adult malignant optic nerve glioma","volume":"242","author":"Wabbels","year":"2004"},{"key":"b19-0050507","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"322","DOI":"10.1212\/WNL.26.4.322","article-title":"Malignant evolution of childhood chiasmal pilocytic astrocytoma","volume":"26","author":"Wilson","year":"1976"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/5\/5\/article-p507.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/5\/5\/article-p507.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/5\/5\/article-p507.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:39:21Z","timestamp":1681562361000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/5\/5\/article-p507.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":19,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2009.12.peds09173","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}