{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:21:42Z","timestamp":1794324102613,"version":"4.9.0"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2009,11]]},"abstract":"\n Object<\/jats:title>\n The pathophysiology of myocardial dysfunction after subarachnoid hemorrhage (SAH) remains unclear. Using myocardial real-time perfusion contrast echocardiography (RTP-CE), the authors evaluated microvascular function in patients with acute SAH.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Over a 15-month period, 10 patients with acute SAH and evidence of cardiac dysfunction were prospectively enrolled. The authors performed RTP-CE within 48 hours of SAH diagnosis. Wall motion and myocardial perfusion were evaluated in 16 left ventricle segments. Qualitative and quantitative RTP-CE analyses were conducted to compare patients with and without regional wall motion abnormalities (RWMAs). Follow-up RTP-CE at a mean of 53.7 \u00b1 43 days was undertaken in patients with baseline RWMAs.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n Ten patients with SAH and evidence of cardiac dysfunction were prospectively enrolled. There were 3 men and 7 women whose mean age was 63.5 \u00b1 10.1 years. The authors documented evidence of RWMAs in 6 patients. Normal perfusion was demonstrated by RTP-CE in all patients at baseline and follow-up, despite the presence of RWMAs. Compared with patients presenting with normal wall motion, in patients with RWMAs there was a trend for higher quantitative RTP-CE parameters, suggesting hyperemia with mean myocardial blood flow velocity (\u03b2, s\n \u22121<\/jats:sup>\n ) of 1.08 \u00b1 0.61 (95% CI 0\u20132.61) compared with 1.62 \u00b1 0.64 (95% CI 0.94\u20132.29) and myocardial blood flow (A \u00d7 \u03b2, dB\/s) of 0.99 \u00b1 0.41 (95% CI 0\u20132.0) versus 1.63 \u00b1 0.86 (95% CI 0.72\u20132.53). Follow-up RTP-CE was feasible in 3 patients with RWMAs. Regional systolic function was restored in those who completed follow-up.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The authors found that RTP-CE readily evaluates microvascular function in patients with SAH. Wall motion and perfusion dissociation were observed. Quantitative RTP-CE showed a trend for microvascular hyperemia in patients with RWMAs, suggesting that post-SAH myocardial dysfunction could occur in the absence of microvascular dysfunction.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2009.3.jns081723","type":"journal-article","created":{"date-parts":[[2009,4,24]],"date-time":"2009-04-24T10:03:55Z","timestamp":1240567435000},"page":"1023-1028","source":"Crossref","is-referenced-by-count":9,"title":["Real-time myocardial perfusion contrast echocardiography and regional wall motion abnormalities after aneurysmal subarachnoid hemorrhage"],"prefix":"10.3171","volume":"111","author":[{"given":"Sahar S.","family":"Abdelmoneim","sequence":"first","affiliation":[{"name":"Divisions of Cardiovascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eelco F. M.","family":"Wijdicks","sequence":"additional","affiliation":[{"name":"Critical Care Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vivien H.","family":"Lee","sequence":"additional","affiliation":[{"name":"Critical Care Neurology, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Wilson P.","family":"Daugherty","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mathieu","family":"Bernier","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae K.","family":"Oh","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Patricia A.","family":"Pellikka","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sharon L.","family":"Mulvagh","sequence":"additional","affiliation":[{"name":"Divisions of Cardiovascular Medicine and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-081723","series-title":"Circulation","first-page":"3314","article-title":"Acute neurocardiogenic injury after subarachnoid hemorrhage","volume":"112","author":"Banki","year":"2005"},{"key":"b2-081723","series-title":"Circulation","first-page":"539","article-title":"Standardized myocardial segmentation and nomenclature for tomographic imaging of the heart: a statement for healthcare professionals from the Cardiac Imaging Committee of the Council on Clinical Cardiology of the American Heart Association","volume":"105","author":"Cerqueira","year":"2002"},{"key":"b3-081723","series-title":"Int J Cardiol","first-page":"189","article-title":"Transient ST elevation and left ventricular asynergy associated with normal coronary artery and Tc-99m PYP Myocardial Infarct Scan in subarachnoid hemorrhage","volume":"63","author":"Chang","year":"1998"},{"key":"b4-081723","series-title":"J Am Coll Cardiol","first-page":"2168","article-title":"Myocardial contrast echocardiography evolving as a clinically feasible technique for accurate, rapid, and safe assessment of myocardial perfusion: the evidence so far","volume":"48","author":"Dijkmans","year":"2006"},{"key":"b5-081723","series-title":"Neurocrit Care","first-page":"243","article-title":"Mechanisms in neurogenic stress cardiomyopathy after aneurysmal subarachnoid hemorrhage","volume":"5","author":"Lee","year":"2006"},{"key":"b6-081723","series-title":"Circulation","first-page":"77","article-title":"The brain-heart connection","volume":"116","author":"Samuels","year":"2007"},{"key":"b7-081723","series-title":"Anesth Analg","first-page":"253","article-title":"Myocardial perfusion following acute subarachnoid hemorrhage in patients with an abnormal electrocardiogram","volume":"76","author":"Szabo","year":"1993"},{"key":"b8-081723","series-title":"Circulation","first-page":"473","article-title":"Quantification of myocardial blood flow with ultrasoundinduced destruction of microbubbles administered as a constant venous infusion","volume":"97","author":"Wei","year":"1998"},{"key":"b9-081723","series-title":"J Am Soc Echocardiogr","first-page":"774","article-title":"Regional patterns of left ventricular systolic dysfunction after subarachnoid hemorrhage: evidence for neurally mediated cardiac injury","volume":"13","author":"Zaroff","year":"2000"},{"key":"b10-081723","series-title":"Stroke","first-page":"1136","article-title":"Regional myocardial perfusion after experimental subarachnoid hemorrhage","volume":"31","author":"Zaroff","year":"2000"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/5\/article-p1023.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/5\/article-p1023.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/111\/5\/article-p1023.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:25:28Z","timestamp":1679898328000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/111\/5\/article-p1023.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":10,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2009.3.jns081723","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}