{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,7,20]],"date-time":"2024-07-20T02:11:26Z","timestamp":1721441486820},"reference-count":25,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2009,8]]},"abstract":"<jats:p>This 14-year-old boy presented with left hemiparesis, gait disturbance, and multiple cranial nerve palsies. Magnetic resonance imaging revealed a multicystic mass with hemorrhagic fluid\u2013fluid levels in the right midbrain, suggesting the presence of a cavernous malformation. Diffusion tensor imaging showed the mass to be close to the right corticospinal tract and ipsilateral medial lemniscus. Subtotal removal of the mass was performed via a right subtemporal approach. The histopathological diagnosis was of a mixed germ cell tumor (GCT) comprising mature teratoma and germinoma cells with syncytiotrophoblastic giant cells. The patient underwent postoperative chemotherapy and radiotherapy, and no tumor progression was found during 1 year of follow-up.<\/jats:p>\n<jats:p>Intracranial GCTs arise mainly in the pineal and the suprasellar area. Germ cell tumors in the brainstem are rare, with only 12 reported cases. Among these, 4 were in the midbrain and histologically were pure germinomas. To the authors' knowledge, this is the first reported case of a mixed GCT in the midbrain combining mature teratoma and germinoma cells.<\/jats:p>","DOI":"10.3171\/2009.3.peds08290","type":"journal-article","created":{"date-parts":[[2009,9,22]],"date-time":"2009-09-22T12:27:00Z","timestamp":1253622420000},"page":"137-142","source":"Crossref","is-referenced-by-count":8,"title":["Mixed germ cell tumor of the midbrain"],"prefix":"10.3171","volume":"4","author":[{"given":"Eun Jung","family":"Koh","sequence":"first","affiliation":[{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ji Hoon","family":"Phi","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sung-Hye","family":"Park","sequence":"additional","affiliation":[{"name":"Departments of Pathology and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"In-One","family":"Kim","sequence":"additional","affiliation":[{"name":"Radiology, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jung-Eun","family":"Cheon","sequence":"additional","affiliation":[{"name":"Radiology, Seoul National University Children's Hospital, Seoul National University College of Medicine, Seoul, Republic of Korea"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kyu-Chang","family":"Wang","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Byung-Kyu","family":"Cho","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Seung-Ki","family":"Kim","sequence":"additional","affiliation":[{"name":"Division of Pediatric Neurosurgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0040137","series-title":"Br J Neurosurg","doi-asserted-by":"publisher","first-page":"310","DOI":"10.1080\/02688690410001732832","article-title":"Primary midbrain germinoma","volume":"18","author":"Ben Amor","year":"2004"},{"key":"b2-0040137","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"285","DOI":"10.1016\/j.surneu.2007.05.005","article-title":"Diffusion tensor-based fiber tracking and intraoperative neuronavigation for the resection of a brainstem cavernous angioma","volume":"68","author":"Chen","year":"2007"},{"key":"b3-0040137","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"30","DOI":"10.1007\/s00381-001-0547-y","article-title":"Pediatric brain tumors: statistics of SNUH, Korea (1959\u20132000)","volume":"18","author":"Cho","year":"2002"},{"key":"b4-0040137","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"384","DOI":"10.1016\/0090-3019(92)90009-C","article-title":"Medulla oblongata germinoma in association with Klinefelter syndrome","volume":"37","author":"Hashimoto","year":"1992"},{"key":"b5-0040137","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"270","DOI":"10.3171\/PED\/2008\/1\/4\/270","article-title":"Diffusion tensor imaging of brainstem tumors: axonal degeneration of motor and sensory tracts","volume":"1","author":"Helton","year":"2008"},{"key":"b6-0040137","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1197","DOI":"10.1007\/s00701-006-0872-8","article-title":"Primary germinoma arising from the midbrain","volume":"148","author":"Koizumi","year":"2006"},{"key":"b7-0040137","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1007\/s00234-001-0752-0","article-title":"MRI of intracranial germ-cell tumours","volume":"44","author":"Liang","year":"2002"},{"key":"b8-0040137","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"292","DOI":"10.1016\/S0303-8467(98)00050-X","article-title":"Primary intracranial germinoma involving the midbrain","volume":"100","author":"Matsumoto","year":"1998"},{"key":"b9-0040137","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"446","DOI":"10.3171\/jns.1997.86.3.0446","article-title":"Primary intracranial germ cell tumors: a clinical analysis of 153 histologically verified cases","volume":"86","author":"Matsutani","year":"1997"},{"key":"b10-0040137","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"93","DOI":"10.1007\/s00701-004-0339-8","article-title":"Radical resection for intrinsic midbrain pilocytic astrocytoma: report of two cases","volume":"147","author":"Miyamoto","year":"2005"},{"key":"b11-0040137","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"448","DOI":"10.1016\/S0090-3019(00)00224-X","article-title":"Primary intracranial germinoma in the medulla oblongata","volume":"53","author":"Nakajima","year":"2000"},{"key":"b12-0040137","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"369","DOI":"10.1002\/cncr.11495","article-title":"Treatment and prognosis of patients with intracranial nongerminomatous malignant germ cell tumors: a multiinstitutional retrospective analysis of 41 patients","volume":"98","author":"Ogawa","year":"2003"},{"key":"b13-0040137","series-title":"Int J Androl","doi-asserted-by":"publisher","first-page":"256","DOI":"10.1111\/j.1365-2605.2007.00793.x","article-title":"Why human extragonadal germ cell tumours occur in the midline of the body: old concepts, new perspectives","volume":"30","author":"Oosterhuis","year":"2007"},{"key":"b14-0040137","series-title":"Pediatr Radiol","doi-asserted-by":"publisher","first-page":"325","DOI":"10.1007\/s00247-005-0063-4","article-title":"Basal ganglia germinoma in children with associated ipsilateral cerebral and brain stem hemiatrophy","volume":"36","author":"Ozelame","year":"2006"},{"key":"b15-0040137","series-title":"J Med Assoc Thai","first-page":"55","article-title":"Brainstem germinoma presenting as intermittent apnoea: a rare entity: report of one patient and review of literature","volume":"74","author":"Poungvarin","year":"1991"},{"key":"b16-0040137","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"192","DOI":"10.1159\/000098831","article-title":"Brainstem tumors: where are we today?","volume":"43","author":"Recinos","year":"2007"},{"key":"b17-0040137","series-title":"Shoni No Noshinkei","first-page":"43","article-title":"[A case of germinoma of the fourth ventricle.]","volume":"8","author":"Saito","year":"1983"},{"key":"b18-0040137","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"258","DOI":"10.3171\/jns.1999.90.2.0258","article-title":"Pathogenesis of intracranial germ cell tumors reconsidered","volume":"90","author":"Sano","year":"1999"},{"key":"b19-0040137","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"758","DOI":"10.1007\/s003810100464","article-title":"Intramedullary immature teratoma in a young infant involving a long segment of the spinal cord","volume":"17","author":"Seol","year":"2001"},{"key":"b20-0040137","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"291","DOI":"10.2176\/nmc.34.291","article-title":"Germinoma of the medulla oblongata\u2014case report","volume":"34","author":"Sugiyama","year":"1994"},{"key":"b21-0040137","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"251","DOI":"10.2176\/nmc.33.251","article-title":"Primary intracranial germinoma involving the medulla oblongata\u2014case report","volume":"33","author":"Tashiro","year":"1993"},{"key":"b22-0040137","series-title":"Neurosurgery","first-page":"185","article-title":"Functional brain mapping and its applications to neurosurgery","volume":"60","author":"Tharin","year":"2007"},{"key":"b23-0040137","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1303","DOI":"10.1007\/PL00010098","article-title":"Malignant teratoma of the medulla oblongata in an adult male","volume":"143","author":"Tsuzuki","year":"2001"},{"key":"b24-0040137","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"255","DOI":"10.1007\/s11060-006-9138-9","article-title":"Primary midbrain cystic germinoma mimicking glioma: a case with neuroendoscopic biopsy","volume":"79","author":"Uchino","year":"2006"},{"key":"b25-0040137","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"339","DOI":"10.1023\/A:1023331700995","article-title":"Primary medulla oblongata germinoma: a case report and review of the literature","volume":"62","author":"Yen","year":"2003"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/2\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/2\/article-p137.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/2\/article-p137.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:39:08Z","timestamp":1681558748000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/2\/article-p137.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2009,8]]},"references-count":25,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2009.3.peds08290","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,8]]}}}