{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,7]],"date-time":"2026-10-07T12:09:03Z","timestamp":1791374943834,"version":"4.3.1"},"reference-count":41,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Observation is an important consideration when discussing management options for patients with vestibular schwannoma (VS). Most data regarding clinical outcomes after conservative management come from modestsized series performed at individual centers. The authors performed an analysis of the published literature on the natural history of VSs with respect to hearing outcome. Their objective was to provide a comprehensive and unbiased description of outcomes in patients whose disease was managed conservatively.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors identified a total of 34 published studies containing hearing outcome data in patients with VSs &lt; 25 mm in largest diameter who underwent observation management. The effects of initial tumor size and tumor growth rate on hearing function at latest follow-up were analyzed. Data from individual and aggregated cases were extracted from each study. Patients with poorer hearing (American Association of Otolaryngology\u2013Head and Neck Surgery Classes C or D, or Gardner-Robertson Classes III, IV, or V) at the time of presentation were excluded.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 982 patients met the inclusion criteria for this analysis, with a mean initial tumor size of 11.3 \u00b1 0.68 mm. The mean growth rate was 2.9 \u00b1 1.2 mm\/year. The length of follow-up for these studies ranged from 26 to 52 months. Patients with preserved hearing at latest follow-up had a statistically larger initial tumor size than those whose hearing declined during the observation period (11.5 \u00b1 2.3 mm vs 9.3 \u00b1 2.7 mm, p &lt; 0.0001), but the 2-mm difference of means was at the limit of imaging resolution and observer reliability. In contrast, patients with lower rates of tumor growth (\u2264 2.5 mm\/year) had markedly higher rates of hearing preservation (75 vs 32%, p &lt; 0.0001) compared with patients with higher tumor growth rates. Interestingly, the authors' analysis found no difference in the rate of reported intervention for patients in either group (16 vs 18%, p = not significant).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>These data suggest that a growth rate of &gt; 2.5 mm\/year is a better predictor of hearing loss than the initial tumor size for patients undergoing observation management of VSs &lt; 25 mm in largest diameter.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2009.4.jns08895","type":"journal-article","created":{"date-parts":[[2009,6,19]],"date-time":"2009-06-19T14:12:20Z","timestamp":1245420740000},"page":"163-167","source":"Crossref","is-referenced-by-count":142,"title":["The natural history of untreated sporadic vestibular schwannomas: a comprehensive review of hearing outcomes"],"prefix":"10.3171","volume":"112","author":[{"given":"Michael E.","family":"Sughrue","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isaac","family":"Yang","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Aranda","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Khadja","family":"Lobo","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lawrence H.","family":"Pitts","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Otolaryngology-Head and Neck Surgery, University of California at San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steven W.","family":"Cheung","sequence":"additional","affiliation":[{"name":"Otolaryngology-Head and Neck 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