{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,27]],"date-time":"2026-03-27T08:59:43Z","timestamp":1774601983666,"version":"3.50.1"},"reference-count":43,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2009,10]]},"abstract":"<jats:p>Ollier disease and Maffucci syndrome are rare syndromes in which there is deforming dysplasia of cartilage, primarily but not exclusively involving the metaphyses and diaphyses of long bones. In a minority of patients, dysplasia can lead to sarcomatous degeneration, producing chondrosarcomas. There also appears to be an association with other neoplasms. Little has been written about the association between Ollier disease and intracranial tumors, and these papers have largely consisted of case reports in adults. The authors present the case of a 6-year-old girl with left arm osseous changes consistent with Ollier disease and a biopsy-proven thalamic glioblastoma multiforme. They then examine the co-occurrence of brain tumors in conjunction with a dyschondroplasia syndrome in children and adolescents to assess the presentation, treatment offered, and disease course of similar cases.<\/jats:p>\n<jats:p>Eight other such cases were identified, 6 in patients with Ollier disease (ranging in age from 7 to 18 years), and 2 with Maffucci syndrome (both in late adolescence). Including our own patient, 7 of the 9 cases of comorbid dyschondroplasia and intracranial malignancy occurred in girls. Some patients presented soon after the acute onset of symptoms, and others had a more subtle, protracted course over as many as 2 years. Some tumors were deemed resectable and others not. In only 1 instance was follow-up beyond 1 year reported.<\/jats:p>","DOI":"10.3171\/2009.5.peds08422","type":"journal-article","created":{"date-parts":[[2009,10,1]],"date-time":"2009-10-01T16:05:27Z","timestamp":1254413127000},"page":"363-367","source":"Crossref","is-referenced-by-count":15,"title":["Pediatric thalamic glioblastoma associated with Ollier disease (multiple enchondromatosis): a rare case of concurrence"],"prefix":"10.3171","volume":"4","author":[{"given":"Adrianna","family":"Ranger","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Artur","family":"Szymczak","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Robert R.","family":"Hammond","sequence":"additional","affiliation":[{"name":"Neuropathology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shayna","family":"Zelcer","sequence":"additional","affiliation":[{"name":"Paediatric Oncology, Children's Hospital, London Health Sciences Center, London, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0040363","series-title":"J Laryngol Otol","doi-asserted-by":"publisher","first-page":"861","DOI":"10.1017\/S0022215100145438","article-title":"Is Ollier's disease an understaging of Maffucci's syndrome?","volume":"113","author":"Ahmed","year":"1999"},{"key":"b2-0040363","series-title":"Leuk Lymphoma","doi-asserted-by":"publisher","first-page":"613","DOI":"10.1080\/10428190310001602381","article-title":"Chronic myeloid leukemia in an adolescent with Ollier's disease after intensive X-ray exposure","volume":"45","author":"Au","year":"2004"},{"key":"b3-0040363","series-title":"J Neuroophthalmol","first-page":"62","article-title":"Neuro-ophthalmologic manifestations of Maffucci's syndrome and Ollier's disease","volume":"19","author":"Balcer","year":"1999"},{"key":"b4-0040363","series-title":"J Bone Joint Surg Br","first-page":"1000","article-title":"The management of leg-length discrepancy in Ollier's disease with a fully implantable lengthening nail","volume":"87","author":"Baumgart","year":"2005"},{"key":"b5-0040363","series-title":"Pediatr Dermatol","first-page":"55","article-title":"What syndrome is this? Ollier disease + vascular lesions: Maffucci syndrome","volume":"12","author":"Bertucci","year":"1995"},{"key":"b6-0040363","series-title":"J Bone Joint Surg Br","first-page":"145","article-title":"Osteosarcoma in enchondromatosis (Ollier's disease). Report of a case","volume":"48","author":"Braddock","year":"1966"},{"key":"b7-0040363","series-title":"Neurosurgery","first-page":"903","article-title":"Identical twins with Ollier's disease and intracranial gliomas: case report","volume":"34","author":"Chang","year":"1994"},{"key":"b8-0040363","series-title":"Gynecol Oncol","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1016\/0090-8258(90)90350-T","article-title":"Ovarian fibrosarcoma associated with Maffucci's syndrome","volume":"37","author":"Christman","year":"1990"},{"key":"b9-0040363","series-title":"Eur J Surg Oncol","first-page":"381","article-title":"Angiosarcoma arising in a patient with Maffucci syndrome","volume":"11","author":"Davidson","year":"1985"},{"key":"b10-0040363","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1007\/s003810050377","article-title":"Diffuse brain stem tumor in an adolescent with multiple enchondromatosis (Ollier's disease)","volume":"15","author":"Frappaz","year":"1999"},{"key":"b11-0040363","series-title":"J Pediatr Adolesc Gynecol","doi-asserted-by":"publisher","first-page":"147","DOI":"10.1016\/S1083-3188(98)70135-4","article-title":"Juvenile granulosa cell tumor in a 13-year-old girl with enchondromatosis (Ollier's disease): a case report","volume":"11","author":"Gell","year":"1998"},{"key":"b12-0040363","series-title":"No Shinkei Geka","first-page":"971","article-title":"[Maffucci's syndrome associated with primary brain tumor: report of a case.]","volume":"15","author":"Goto","year":"1987"},{"key":"b13-0040363","series-title":"Skeletal Radiol","doi-asserted-by":"publisher","first-page":"688","DOI":"10.1007\/s002560050460","article-title":"Simultaneous occurrence of a supra- and an infratentorial glioma in a patient with Ollier's disease: more evidence for non-mesodermal tumor predisposition in multiple enchondromatosis","volume":"27","author":"Hofman","year":"1998"},{"key":"b14-0040363","series-title":"J Med Assoc Thai","first-page":"288","article-title":"Maffucci's syndrome with frontal lobe astrocytoma","volume":"73","author":"Jirarattanaphochai","year":"1990"},{"key":"b15-0040363","series-title":"Hop","first-page":"2001","article-title":"[Maffucci-Kast syndrome.]","volume":"38","author":"Justin-Besancon","year":"1962"},{"key":"b16-0040363","series-title":"Virchows Archiv Anat Physiol Med (Berlin)","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/BF01942409","article-title":"Ein Fall von Enchondrom mit ungew\u00f6hnlicher Multiplikation","volume":"118","author":"Kast","year":"1889"},{"key":"b17-0040363","series-title":"Neurosurg Q","doi-asserted-by":"publisher","first-page":"195","DOI":"10.1097\/01.wnq.0000214039.38720.b4","article-title":"Ollier disease anaplastic mixed oligoastrocytoma: a rare association with brain tumors","volume":"16","author":"Koc","year":"2006"},{"key":"b18-0040363","series-title":"Skeletal Radiol","first-page":"609","article-title":"Esthesioneuroblastoma in Maffucci's syndrome","volume":"33","author":"Kurian","year":"2004"},{"key":"b19-0040363","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1376","DOI":"10.1002\/1097-0142(19870401)59:7<1376::AID-CNCR2820590725>3.0.CO;2-F","article-title":"Bone sarcomas associated with Ollier's disease","volume":"59","author":"Liu","year":"1987"},{"key":"b20-0040363","series-title":"Mov Med Chir Napoli","first-page":"399","article-title":"Di un caso di encondroma ed angioma multiplo. Contribuzione alla genesi embrionale dei tumori","volume":"13","author":"Maffucci"},{"key":"b21-0040363","series-title":"Saudi Med J","first-page":"1261","article-title":"Multiple enchondromatosis Ollier's disease with two primary brain tumors","volume":"25","author":"Mahafza","year":"2004"},{"key":"b22-0040363","series-title":"J Neurol","doi-asserted-by":"publisher","first-page":"376","DOI":"10.1007\/BF00314239","article-title":"Ollier's disease and Maffucci's syndrome: distinct entities or a continuum. Case report: enchondromatosis complicated by an intracranial glioma","volume":"235","author":"Mellon","year":"1988"},{"key":"b23-0040363","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"79","DOI":"10.1007\/BF02076022","article-title":"A rare case of Maffucci's syndrome combined with tuberculum sellae enchondroma, pituitary adenoma and thyroid adenoma","volume":"87","author":"Miki","year":"1987"},{"key":"b24-0040363","series-title":"Zh Nevropatol Psikhiatr Im S S Korsakova","first-page":"17","article-title":"[Neurologic manifestations in Ollier's disease.]","volume":"91","author":"Neretin","year":"1991"},{"key":"b25-0040363","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"336","DOI":"10.1007\/BF01808830","article-title":"Thalamic gliomas: a clinicopathologic analysis of 20 cases with reference to patient age","volume":"139","author":"Nishio","year":"1997"},{"key":"b26-0040363","series-title":"Acta Oncol","doi-asserted-by":"publisher","first-page":"705","DOI":"10.1080\/02841860410002770","article-title":"Chondrosarcomas of the base of the skull in Ollier's disease or Maffucci's syndrome\u2014three case reports and review of the literature","volume":"43","author":"No\u00ebl","year":"2004"},{"key":"b27-0040363","series-title":"Bull Soc Lyon Med","first-page":"23","article-title":"[Dyschondroplasia.]","volume":"93","author":"Ollier","year":"1899"},{"key":"b28-0040363","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1227\/00006123-199009000-00029","article-title":"A case of dyschondroplasia associated with brain stem glioma: diagnosis by stereotactic biopsy","volume":"27","author":"Patt","year":"1990"},{"key":"b29-0040363","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"269","DOI":"10.1097\/00006123-199707000-00046","article-title":"Maffucci's syndrome associated with a cranial base chondrosarcoma: case report and literature review","volume":"41","author":"Ramina","year":"1997"},{"key":"b30-0040363","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"400","DOI":"10.1227\/00006123-198709000-00023","article-title":"A case of Ollier's disease associated with two intracranial gliomas","volume":"21","author":"Rawlings","year":"1987"},{"key":"b31-0040363","series-title":"Am J Pediatr Hematol Oncol","first-page":"427","article-title":"Acute lymphoid leukemia associated with Maffucci's syndrome","volume":"15","author":"Rector","year":"1993"},{"key":"b32-0040363","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"151","DOI":"10.1007\/BF00346758","article-title":"Parasellar chondrosarcoma in a patient with Ollier's disease","volume":"22","author":"Reuter","year":"1981"},{"key":"b33-0040363","series-title":"No To Shinkei","first-page":"631","article-title":"[A case of Maffucci's syndrome with brain-stem tumor.]","volume":"41","author":"Sato","year":"1989"},{"key":"b34-0040363","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"269","DOI":"10.2106\/00004623-198769020-00016","article-title":"The malignant potential of enchondromatosis","volume":"69","author":"Schwartz","year":"1987"},{"key":"b35-0040363","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"95","DOI":"10.2106\/00004623-198264010-00014","article-title":"Ollier's disease. An assessment of angular deformity, shortening, and pathological fracture in twenty-one patients","volume":"64","author":"Shapiro","year":"1982"},{"key":"b36-0040363","series-title":"T\u00fcrk N\u00f6rosir\u00fcrji Dergisi","first-page":"66","article-title":"Ollier hastali\u011fina e\u015flik eden \u0130ntracranial glioma","volume":"12","author":"\u015eim\u015fek","year":"2002"},{"key":"b37-0040363","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1605","DOI":"10.1002\/1097-0142(19840401)53:7<1605::AID-CNCR2820530731>3.0.CO;2-N","article-title":"Enchondromatosis (Ollier's disease) and ovarian juvenile granulosa cell tumor","volume":"53","author":"Tamimi","year":"1984"},{"key":"b38-0040363","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"106","DOI":"10.1016\/S0303-8467(98)00072-9","article-title":"A case of Ollier's disease associated with two intracerebral low-grade gliomas","volume":"101","author":"van Nielen","year":"1999"},{"key":"b39-0040363","series-title":"J Pediatr","doi-asserted-by":"publisher","first-page":"945","DOI":"10.1016\/S0022-3476(86)80936-2","article-title":"Ollier disease (enchondromatosis) associated with ovarian juvenile granulosa cell tumor and precocious pseudopuberty","volume":"108","author":"Vaz","year":"1986"},{"key":"b40-0040363","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"222","DOI":"10.1002\/1097-0142(19880701)62:1<222::AID-CNCR2820620134>3.0.CO;2-W","article-title":"Ollier's disease associated with ovarian juvenile granulosa cell tumor","volume":"62","author":"Velasco-Oses","year":"1988"},{"key":"b41-0040363","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"59","DOI":"10.1007\/s11060-008-9583-8","article-title":"Cerebellar anaplastic astrocytoma in a teenager with Ollier Disease","volume":"89","author":"Walid","year":"2008"},{"key":"b42-0040363","series-title":"Am J Pediatr Hematol Oncol","doi-asserted-by":"publisher","first-page":"49","DOI":"10.1097\/00043426-199121000-00012","article-title":"Ollier's disease associated with ovarian Sertoli-Leydig cell tumor and breast adenoma","volume":"13","author":"Weyl-Ben Arush","year":"1991"},{"key":"b43-0040363","series-title":"Pediatr Blood Cancer","doi-asserted-by":"publisher","first-page":"645","DOI":"10.1002\/pbc.21050","article-title":"Acute myelogenous leukemia associated with Ollier disease","volume":"50","author":"White","year":"2008"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/4\/article-p363.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/4\/article-p363.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/4\/article-p363.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T11:35:52Z","timestamp":1681558552000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/4\/article-p363.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2009,10]]},"references-count":43,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2009.5.peds08422","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,10]]}}}