{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T01:33:02Z","timestamp":1778117582809,"version":"3.51.4"},"reference-count":16,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,1]]},"abstract":"<jats:p>Lymphocytic hypophysitis is a relatively uncommon autoimmune inflammatory disorder affecting the pituitary gland. It most frequently occurs in women of child-bearing age. The authors report on their experience with a patient who presented with diplopia and marked enlargement of the pituitary gland. She underwent transsphenoidal surgery, and histopathological analysis confirmed the diagnosis of lymphocytic hypophysitis. The disease proved refractory to resection, and any attempt at withdrawal of corticosteroid therapy resulted in a return of the patient's symptoms and enlargement of the sellar contents.<\/jats:p>\n<jats:p>The patient underwent Gamma Knife surgery (GKS) to the sella and both cavernous sinuses. After GKS, the patient was able to discontinue steroid therapy without return of her symptoms. Follow-up MR images demonstrated no evidence of recurrence of lymphocytic hypophysitis.<\/jats:p>\n<jats:p>For persistent lymphocytic hypophysitis, GKS is a reasonable treatment option.<\/jats:p>","DOI":"10.3171\/2009.6.jns081176","type":"journal-article","created":{"date-parts":[[2009,6,26]],"date-time":"2009-06-26T18:34:12Z","timestamp":1246041252000},"page":"118-121","source":"Crossref","is-referenced-by-count":41,"title":["Gamma Knife surgery for lymphocytic hypophysitis"],"prefix":"10.3171","volume":"112","author":[{"given":"Dibyendu Kumar","family":"Ray","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Chun Po","family":"Yen","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mary Lee","family":"Vance","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Edward R.","family":"Laws","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Beatriz","family":"Lopes","sequence":"additional","affiliation":[{"name":"Division of Neuropathology, University of Virginia, Charlottesville, Virginia; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jason P.","family":"Sheehan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-1120118","series-title":"Minerva Med","first-page":"637","article-title":"Autoimmune hypophysitis. 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Report of two cases","volume":"99","author":"Selch","year":"2003"},{"key":"b14-1120118","series-title":"J Neurosurg","first-page":"678","article-title":"Stereotactic radiosurgery for pituitary adenomas: an intermediate review of its safety, efficacy, and role in the neurosurgical treatment armamentarium","volume":"102","author":"Sheehan","year":"2005"},{"key":"b15-1120118","series-title":"J Endocrinol Invest","first-page":"353","article-title":"Hypophysitis associated with a ruptured Rathke's cleft cyst in a woman, during pregnancy","volume":"29","author":"Sonnet","year":"2006"},{"key":"b16-1120118","series-title":"Endocrine","first-page":"85","article-title":"Lymphocytic hypophysitis: late recurrence following successful transsphenoidal surgery","volume":"25","author":"Tsagarakis","year":"2004"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/112\/1\/article-p118.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/112\/1\/article-p118.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/112\/1\/article-p118.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T08:30:41Z","timestamp":1679905841000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/112\/1\/article-p118.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2010,1]]},"references-count":16,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2009.6.jns081176","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,1]]}}}