{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:23:19Z","timestamp":1794324199836,"version":"4.9.0"},"reference-count":60,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>\n                    Whipple disease is a multisystem infectious disease caused by\n                    <jats:italic>Tropheryma whippleii<\/jats:italic>\n                    . It commonly affects the CNS and produces neurological symptoms in 10\u201320% of cases. Central nervous system Whipple disease occurring in patients with AIDS is extremely rare. The authors present a case of a newly diagnosed AIDS patient in whom intracranial Whipple disease was diagnosed by stereotactic brain biopsy.\n                  <\/jats:p>","DOI":"10.3171\/2009.6.jns0935","type":"journal-article","created":{"date-parts":[[2009,7,17]],"date-time":"2009-07-17T10:15:28Z","timestamp":1247825728000},"page":"983-989","source":"Crossref","is-referenced-by-count":9,"title":["Whipple disease of the central nervous system: an unusual occurrence in association with acquired immune deficiency syndrome"],"prefix":"10.3171","volume":"112","author":[{"given":"Bharat","family":"Guthikonda","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, LSU Health Science Center\u2013Shreveport, Louisiana; Departments of"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilie","family":"Rouah","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bhuvanaswari","family":"Krishnan","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Suzanne Z.","family":"Powell","sequence":"additional","affiliation":[{"name":"Department of Pathology, Weill Medical College of Cornell University, The Methodist Hospital; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Clay","family":"Goodman","sequence":"additional","affiliation":[{"name":"Pathology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shankar P.","family":"Gopinath","sequence":"additional","affiliation":[{"name":"Neurosurgery, Baylor College of Medicine;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Richard K.","family":"Simpson","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, The Methodist Neurological Institute, Houston, Texas"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1120983","series-title":"Ann Neurol","first-page":"104","article-title":"Whipple's disease confined to the central nervous system","volume":"21","author":"Adams","year":"1987"},{"key":"b2-1120983","series-title":"Acta Neurochir (Wien)","first-page":"214","article-title":"Diagnostic value of stereotactic biopsy of cerebral lesions in patients with AIDS","volume":"134","author":"Alesch","year":"1995"},{"key":"b3-1120983","series-title":"Arch Pathol Lab Med","first-page":"497","article-title":"An unusual central nervous system infection in a young immunocompromised host","volume":"110","author":"Ambler","year":"1986"},{"key":"b4-1120983","series-title":"Neurology","first-page":"1233","article-title":"Evaluation and management of intracranial mass lesions in AIDS: report of the Quality Standards Subcommittee of the American Academy of Neurology","volume":"51","author":"Antinori","year":"1998"},{"key":"b5-1120983","series-title":"Lancet","first-page":"767","article-title":"AIDS in a Haitian woman with cardiac Kaposi's sarcoma and Whipple's disease","volume":"1","author":"Autran","year":"1983"},{"key":"b6-1120983","series-title":"J Neurol Neurosurg Psychiatry","first-page":"203","article-title":"Encephalopathy in a case of Whipple's disease","volume":"26","author":"Badenoch","year":"1963"},{"key":"b7-1120983","series-title":"Scand J Infect Dis","first-page":"623","article-title":"Isolated CNS Whipple disease: acute onset and relapsing-remitting course","volume":"39","author":"Benito-Leon","year":"2007"},{"key":"b8-1120983","series-title":"Gastroenterology","first-page":"1139","article-title":"Impaired bacterial degradation by monocytes and macrophages from a patient with treated Whipple's disease","volume":"89","author":"Bjerknes","year":"1985"},{"key":"b9-1120983","series-title":"J Neurosurg","first-page":"623","article-title":"Whipple's disease presenting with isolated neurological symptoms. 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Histological and clinical comparison with Whipple's disease","volume":"30","author":"Roth","year":"1985"},{"key":"b47-1120983","series-title":"Gastroenterology","first-page":"745","article-title":"Reversal of dementia associated with Whipple's disease by trimethoprim-sulfamethoxazole, drugs that penetrate the blood-brain barrier","volume":"86","author":"Ryser","year":"1984"},{"key":"b48-1120983","series-title":"Ann Intern Med","first-page":"51","article-title":"Encephalopathy complicating Whipple's disease: failure to respond to antibiotics","volume":"94","author":"Schmitt","year":"1981"},{"key":"b49-1120983","series-title":"Eur J Gastroenterol Hepatol","first-page":"899","article-title":"Long-term follow-up in cerebral Whipple's disease","volume":"8","author":"Schnider","year":"1996"},{"key":"b50-1120983","series-title":"Ann Neurol","first-page":"677","article-title":"Oculomasticatory myorhythmia: a unique movement disorder occurring in Whipple's disease","volume":"20","author":"Schwartz","year":"1986"},{"key":"b51-1120983","series-title":"Mov Disord","first-page":"195","article-title":"Oculofacial-skeletal myorhythmia in central nervous system Whipple's disease: additional case and review of the literature","volume":"10","author":"Simpson","year":"1995"},{"key":"b52-1120983","series-title":"Clin Infect Dis","first-page":"883","article-title":"Presumed central nervous system Whipple's disease in a child: case report","volume":"20","author":"Tan","year":"1995"},{"key":"b53-1120983","series-title":"Mov Disord","first-page":"82","article-title":"Permanent bruxism as a manifestation of the oculo-facial syndrome related to systemic Whipple's disease","volume":"7","author":"Tison","year":"1992"},{"key":"b54-1120983","series-title":"Gastroenterology","first-page":"434","article-title":"Whipple's disease: staging and monitoring by cytology and polymerase chain reaction analysis of cerebrospinal fluid","volume":"113","author":"von Herbay","year":"1997"},{"key":"b55-1120983","series-title":"Brain","first-page":"2016","article-title":"Brain biopsy in dementia","volume":"128","author":"Warren","year":"2005"},{"key":"b56-1120983","series-title":"John Hopkins Med Bull","first-page":"382","article-title":"A hitherto undescribed disease characterized anatomically by deposits of fat and fatty acids in the intestinal and mesenteric lymphatic tissues","volume":"198","author":"Whipple","year":"1907"},{"key":"b57-1120983","series-title":"Arch Psychiatr Nervenkr","first-page":"283","article-title":"Diagnosis of cerebral Whipple's disease by cerebrospinal fluid cytology","volume":"231","author":"Wietholter","year":"1982"},{"key":"b58-1120983","series-title":"J Neurol Neurosurg Psychiatry","first-page":"989","article-title":"Whipple's disease confined to the CNS presenting with multiple intracerebral mass lesions","volume":"54","author":"Wroe","year":"1991"},{"key":"b59-1120983","series-title":"Bull Johns Hopkins Hosp","first-page":"80","article-title":"Combined electron and light microscopy in Whipple's disease. Demonstration of \u201cbacillary bodies\u201d in the intestine","volume":"109","author":"Yardley","year":"1961"},{"key":"b60-1120983","series-title":"Singapore Med J","first-page":"161","article-title":"Stereotactic brain biopsies in AIDS patients\u2014early local experience","volume":"41","author":"Yeo","year":"2000"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/112\/5\/article-p983.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/112\/5\/article-p983.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/112\/5\/article-p983.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T03:25:28Z","timestamp":1679887528000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/112\/5\/article-p983.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2010,5]]},"references-count":60,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2009.6.jns0935","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,5]]}}}