{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:21:48Z","timestamp":1794324108195,"version":"4.9.0"},"reference-count":11,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2009,11]]},"abstract":"<jats:p>Many treatments for posttraumatic, skull base aneurysms have been described. Eight months after an all-terrain-vehicle accident, this 12-year-old girl presented with right-side Horner syndrome caused by a 33 \u00d7 19\u2013mm internal carotid artery aneurysm at the C-1 level. We chose to treat the aneurysm with a new liquid embolic agent for wide-necked, side-wall aneurysms (Onyx HD 500). We felt this treatment would result in less morbidity than surgery and was less likely to occlude the parent artery than placement of a covered stent, especially in a smaller artery in a pediatric patient. Liquid embolic agents also appear to be associated with a lower chance of recanalization and lower cost compared with stent-assisted coil embolization. After the patient was treated with loading doses of aspirin, clopidogrel bisulfate, and heparin, 99% of the aneurysm was embolized with 9 cc of the liquid embolic agent. There were no complications, and the patient remained neurologically stable. Follow-up angiography revealed durable aneurysm occlusion after 1 year. The cost of Onyx was less than the cost of coils required for coil embolization of similarly sized intracranial aneurysms at our institution. Liquid embolic agents can provide a safe, efficacious, and cost-effective approach to treatment of select giant, posttraumatic, skull base aneurysms in pediatric patients.<\/jats:p>","DOI":"10.3171\/2009.6.peds0953","type":"journal-article","created":{"date-parts":[[2009,10,30]],"date-time":"2009-10-30T09:57:44Z","timestamp":1256896664000},"page":"449-452","source":"Crossref","is-referenced-by-count":11,"title":["Embolization of a giant pediatric, posttraumatic, skull base internal carotid artery aneurysm with a liquid embolic agent"],"prefix":"10.3171","volume":"4","author":[{"given":"Adam S.","family":"Reig","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Scott","family":"Simon","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Mericle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0040449","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"835","DOI":"10.1227\/01.NEU.0000298913.24625.26","article-title":"The effect of vascular reconstruction device-assisted coiling on packing density, effective neck coverage, and angiographic outcome: an in vitro study","volume":"61","author":"Bendok","year":"2007"},{"key":"b2-0040449","series-title":"Neuroradiology","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1007\/s00234-005-0007-6","article-title":"Late angiographic and clinical follow-up results of 100 consecutive aneurysms treated with Onyx reconstruction: largest single-center experience","volume":"48","author":"Cekirge","year":"2006"},{"key":"b3-0040449","series-title":"Curr Opin Otolaryngol Head Neck Surg","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1097\/00020840-200404000-00010","article-title":"Contemporary management of carotid blowout","volume":"12","author":"Cohen","year":"2004"},{"key":"b4-0040449","series-title":"Catheter Cardiovasc Interv","doi-asserted-by":"publisher","first-page":"353","DOI":"10.1002\/ccd.10223","article-title":"Results of the Jostent coronary stent graft implantation in various clinical settings: procedural and follow-up results","volume":"56","author":"Gercken","year":"2002"},{"key":"b5-0040449","series-title":"J Endovasc Ther","doi-asserted-by":"publisher","first-page":"734","DOI":"10.1583\/1308R.1","article-title":"Internal carotid artery aneurysm with life-threatening hemorrhages in a pediatric patient: endovascular treatment options","volume":"11","author":"Gralla","year":"2004"},{"key":"b6-0040449","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"793","DOI":"10.1097\/00006123-199910000-00013","article-title":"Clinical and angiographic results of endosaccular coiling treatment of giant and very large intracranial aneurysms: a 7-year, single-center experience","volume":"45","author":"Gruber","year":"1999"},{"key":"b7-0040449","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"561","DOI":"10.3171\/jns.2000.93.4.0561","article-title":"Natural history of the neck remnant of a cerebral aneurysm treated with the Guglielmi detachable coil system","volume":"93","author":"Hayakawa","year":"2000"},{"key":"b8-0040449","series-title":"AJNR Am J Neuroradiol","first-page":"39","article-title":"Cerebral Aneurysm Multicenter European Onyx (CAMEO) trial: results of a prospective observational study in 20 European centers","volume":"25","author":"Molyneux","year":"2004"},{"key":"b9-0040449","series-title":"AJNR Am J Neuroradiol","first-page":"257","article-title":"Coiling of very large or giant cerebral aneurysms: long-term clinical and serial angiographic results","volume":"24","author":"Sluzewski","year":"2003"},{"key":"b10-0040449","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"77","DOI":"10.3171\/JNS\/2008\/109\/7\/0077","article-title":"Onyx in an experimental aneurysm model: histological and angiographic results","volume":"109","author":"Struffert","year":"2008"},{"key":"b11-0040449","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"240","DOI":"10.3171\/PED\/2008\/1\/3\/240","article-title":"Extracranial carotid artery pseudoaneurysm presenting with embolic stroke in a pediatric patient. Case report","volume":"1","author":"Wolfe","year":"2008"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/5\/article-p449.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/5\/article-p449.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/4\/5\/article-p449.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T07:40:22Z","timestamp":1681544422000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/4\/5\/article-p449.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2009,11]]},"references-count":11,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2009.6.peds0953","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2009,11]]}}}