{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:03:10Z","timestamp":1780131790395,"version":"3.54.0"},"reference-count":86,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2009,9]]},"abstract":"<jats:p>The search for efficacious, minimally invasive neurosurgical treatment has led to the development of the operating microscope, endovascular treatment, and endoscopic surgery. One of the most minimally invasive and exciting discoveries is the use of targeted, high-dose radiation for neurosurgical disorders. Radiosurgery is truly minimally invasive, delivering therapeutic energy to an accurately defined target without an incision, and has been used to treat a wide variety of pathological conditions, including benign and malignant brain tumors, vascular lesions such as arteriovenous malformations, and pain syndromes such as trigeminal neuralgia. Over the last 50 years, a tremendous amount of knowledge has been garnered, both about target volume and radiation delivery. This review covers the intense study of these concepts and the development of linear accelerators to deliver stereotactic radiosurgery. The fascinating history of stereotactic neurosurgery is reviewed, and a detailed account is given of the development of linear accelerators and their subsequent modification for radiosurgery.<\/jats:p>","DOI":"10.3171\/2009.7.focus09116","type":"journal-article","created":{"date-parts":[[2009,9,1]],"date-time":"2009-09-01T09:57:01Z","timestamp":1251799021000},"page":"E13","source":"Crossref","is-referenced-by-count":26,"title":["Stereotactic radiosurgery and the linear accelerator: accelerating electrons in neurosurgery"],"prefix":"10.3171","volume":"27","author":[{"given":"Maryam","family":"Rahman","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gregory J. A.","family":"Murad","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Bova","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William A.","family":"Friedman","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J","family":"Mocco","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Florida, Gainesville, Florida"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0270013","series-title":"Stereotact Funct Neurosurg","first-page":"124","article-title":"The Cyberknife: a frameless robotic system for radiosurgery","volume":"69","author":"Adler","year":"1997"},{"key":"b2-0270013","series-title":"Radiol Med (Torino)","first-page":"124","article-title":"[Stereotaxic irradiation with a linear accelerator.]","volume":"70","author":"Avanzo","year":"1984"},{"key":"b3-0270013","series-title":"Med Phys","first-page":"4262","article-title":"Anniversary paper: the role of medical physicists in developing stereotactic radiosurgery","volume":"35","author":"Benedict","year":"2008"},{"key":"b4-0270013","series-title":"Neurochirurgie","first-page":"295","article-title":"[Multiple-beam stereotaxic irradiation.]","volume":"29","author":"Betti","year":"1983"},{"key":"b5-0270013","series-title":"Appl Neurophysiol","first-page":"262","article-title":"Treatment of arteriovenous malformations with the linear accelerator","volume":"50","author":"Betti","year":"1987"},{"key":"b6-0270013","series-title":"Stereotact Funct Neurosurg","first-page":"87","article-title":"Radiosurgery with a linear accelerator. 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