{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2024,2,23]],"date-time":"2024-02-23T11:53:25Z","timestamp":1708689205681},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2009,12]]},"abstract":"\nObject<\/jats:title>\nFrontoethmoidal meningoencephalocele (fMEC) is relatively common in many Southeast Asian countries, with devastating aesthetic and social consequences for affected children. No cause has been detected to date. Among other factors, the authors of this paper attempt to identify a statistically significant difference in the spread of fMEC births throughout the year compared with other births. This seasonal variation in the incidence of fMEC births may provide clues to the causes of this condition.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nFrom a group of 175 children with fMEC who underwent surgery at the authors' humanitarian institution (Children's Surgical Centre) in Phnom Penh between 2004 and 2008, 86 children were studied. These children were born at full term and had an accurately recorded date of birth. The birth dates of this fMEC group were compared with a group of > 15,000 other live births at one of the main maternity units in Phnom Penh in 2005 and 2006.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nSeasonal variation in incidence of fMEC by month of birth was highly statistically significant (p < 0.001), with the peak of births occurring in the dry season (between March and May). This is in contrast to the control group, in which there was an equal distribution of births throughout the year. More than 85% of the parents of children with fMEC who the authors treated were farmers, but this figure reflects the composition of the Cambodian population.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nUneven spread in the incidence of fMEC births throughout the year suggests that a seasonal factor during the wet season may be suspected in the pathogenesis of fMEC in Cambodia.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2009.7.peds08403","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T15:03:35Z","timestamp":1259679815000},"page":"553-556","source":"Crossref","is-referenced-by-count":10,"title":["Seasonal variations in frontoethmoidal meningoencephalocele births in Cambodia"],"prefix":"10.3171","volume":"4","author":[{"given":"Franck-Emmanuel","family":"Roux","sequence":"first","affiliation":[{"name":"Service de Neurochirurgie, and"},{"name":"M\u00e9decins du Monde, Paris, France; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ngiep","family":"Oucheng","sequence":"additional","affiliation":[{"name":"Children's Surgical Centre at Kien Khlean, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Val\u00e9rie","family":"Lauwers-Cances","sequence":"additional","affiliation":[{"name":"Service d'\u00e9pid\u00e9miologie, Centres Hospitalo-Universitaires, Toulouse;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Louisa","family":"Draper","sequence":"additional","affiliation":[{"name":"Children's Surgical Centre at Kien Khlean, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christelle","family":"Cristini","sequence":"additional","affiliation":[{"name":"Service d'\u00e9pid\u00e9miologie, Centres Hospitalo-Universitaires, Toulouse;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jim","family":"Collogly","sequence":"additional","affiliation":[{"name":"Children's Surgical Centre at Kien Khlean, Phnom Penh, Cambodia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fr\u00e9d\u00e9ric","family":"Lauwers","sequence":"additional","affiliation":[{"name":"M\u00e9decins du Monde, Paris, France; and"},{"name":"Chirurgie Maxillo-Faciale, H\u00f4pital Purpan;"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0040553","series-title":"J Oral Maxillofac Surg","doi-asserted-by":"publisher","first-page":"7","DOI":"10.1016\/0278-2391(89)90115-8","article-title":"A study of etiologic factors for cleft lip and palate in Sri Lanka","volume":"47","author":"Amaratunga","year":"1989"},{"key":"b2-0040553","series-title":"P R Health Sci J","first-page":"343","article-title":"Seasonal variation in the incidence of cleft lip and palate based on the age of conception","volume":"25","author":"De la Vega","year":"2006"},{"key":"b3-0040553","series-title":"Acta Paediatr Scand","doi-asserted-by":"publisher","first-page":"373","DOI":"10.1111\/j.1651-2227.1989.tb11095.x","article-title":"Foetal and neonatal exposure to aflatoxins","volume":"78","author":"De Vries","year":"1989"},{"key":"b4-0040553","series-title":"Humangenetik","first-page":"1","article-title":"Fronto-ethmoidal encephalomeningoceles in the population of northern Thailand","volume":"11","author":"Flatz","year":"1970"},{"key":"b5-0040553","series-title":"Anat Embryol (Berl)","first-page":"455","article-title":"Separation of neural and surface extoderm after closure of the rostral neuropore","volume":"182","author":"Hoving","year":"1990"},{"key":"b6-0040553","series-title":"Am J Hum Biol","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1002\/ajhb.20799","article-title":"Strong association between birth month and reproductive performance of Vietnamese women","volume":"21","author":"Huber","year":"2009"},{"key":"b7-0040553","series-title":"Cambodia Demographic and Health Survey 2000. 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