{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,26]],"date-time":"2026-06-26T22:37:16Z","timestamp":1782513436605,"version":"3.54.5"},"reference-count":19,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,5]]},"abstract":"<jats:p>The authors present the case of a patient that demonstrates the long-standing use of megestrol acetate, a progesterone agonist, and its association with multiple intracranial meningioma presentation. Discontinuation of megestrol acetate led to shrinkage of multiple tumors and to the complete resolution of one tumor. Histological examination demonstrated that the largest tumor had high (by &gt; 25% of tumor cell nuclei) progesterone-positive expression, including progesterone receptor (PR) isoform B, compared with low expression of PR isoform A; there was no evidence of estrogen receptor expression and only unaccentuated collagen expression. This is the first clinical report illustrating a causal relationship between exogenous hormones and modulation of meningioma biology in situ.<\/jats:p>","DOI":"10.3171\/2009.8.jns09201","type":"journal-article","created":{"date-parts":[[2009,9,4]],"date-time":"2009-09-04T14:09:23Z","timestamp":1252073363000},"page":"920-924","source":"Crossref","is-referenced-by-count":60,"title":["Regression of multiple intracranial meningiomas after cessation of long-term progesterone agonist therapy"],"prefix":"10.3171","volume":"112","author":[{"given":"Sudhakar","family":"Vadivelu","sequence":"first","affiliation":[{"name":"The Brain Tumor Institute at the Harvey Cushing Institutes of Neuroscience, and"},{"name":"Department of Neurosurgery, North Shore University\u2013Long Island Jewish Hospitals, Manhasset, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Leroy","family":"Sharer","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Medicine and Dentistry, New Jersey School of Medicine, Newark, New Jersey"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael","family":"Schulder","sequence":"additional","affiliation":[{"name":"The Brain Tumor Institute at the Harvey Cushing Institutes of Neuroscience, and"},{"name":"Department of Neurosurgery, North Shore University\u2013Long Island Jewish Hospitals, Manhasset, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1120920","series-title":"J Neurol Neurosurg Psychiatry","first-page":"89","article-title":"The relapsing course of certain meningiomas in relation to pregnancy and menstruation","volume":"21","author":"Bickerstaff","year":"1958"},{"key":"b2-1120920","series-title":"J Neurooncol","first-page":"1","article-title":"Progesterone receptor isoforms expression pattern in human chordomas","volume":"49","author":"Camacho-Arroyo","year":"2000"},{"key":"b3-1120920","series-title":"Cancer","first-page":"471","article-title":"Exogenous hormone use and meningioma risk: what do we tell our patients?","volume":"110","author":"Claus","year":"2007"},{"key":"b4-1120920","series-title":"Cancer Res","first-page":"314","article-title":"Specific genes expressed in association with progesterone receptors in meningioma","volume":"68","author":"Claus","year":"2008"},{"key":"b5-1120920","series-title":"Proc Natl Acad Sci U S A","first-page":"2187","article-title":"Thermodynamic analysis of progesterone receptor-promoter interactions reveals a molecular model for isoform-specific function","volume":"104","author":"Connaghan-Jones","year":"2007"},{"key":"b6-1120920","series-title":"Brain Res Bull","first-page":"43","article-title":"Progesterone receptor isoforms expression pattern in human astrocytomas","volume":"56","author":"Gonz\u00e1lez-Ag\u00fcero","year":"2001"},{"key":"b7-1120920","series-title":"J Neurosurg","first-page":"328","article-title":"Multiple meningiomas arising during long-term therapy with the progesterone agonist megestrol acetate. 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