{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:02:59Z","timestamp":1780131779006,"version":"3.54.0"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2009,12]]},"abstract":"\n Object<\/jats:title>\n Stereotactic radiosurgery (SRS) has become an important treatment alternative to surgery for a variety of spinal lesions. However, the use of SRS in the management of intradural intramedullary (IDIM) metastasis remains controversial. The aim of this study was to determine the clinical efficacy and safety of SRS for treatment of IDIM metastasis.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Nine patients with 11 IDIM metastases treated with SRS at Henry Ford Hospital were retrospectively reviewed. The mean age at presentation was 50 years, with a range of 14\u201371 years. There were 4 intradural extramedullary and 7 intramedullary lesions. The radiosurgery procedure used techniques of image-guided and intensitymodulated radiation. The mean treatment dose was 13.8 Gy, with a range of 10\u201316 Gy. All patients had clinical follow-up (except in 1 lesion), with an emphasis on initial symptoms and ambulatory status, and 8 patients (9 lesions) had imaging studies. The median follow-up duration was 10 months.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n The presenting symptoms were improved in 8 (80%) of 10 evaluable lesions, unchanged in 1 case, and worsened in 1 case. Radiographic responses were seen as follows: complete response in 2 (22%) of 9; partial response in 3 (33%) of 9; stable disease in 3 (33%) of 9; and progressive disease in 1 (11%) of 9. After radiosurgery, 7 patients (78%) remained ambulatory until the last follow-up visit. The overall median survival time after SRS was 8 months, with a range of 2\u201319 months. No radiation toxicity was detected clinically during the follow-up period.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Despite the fact that this was a small series of patients with IDIM metastasis who had limited treatment options, SRS appears to be an effective and safe method of treating patients with these lesions.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2009.9.focus09194","type":"journal-article","created":{"date-parts":[[2009,12,1]],"date-time":"2009-12-01T10:04:21Z","timestamp":1259661861000},"page":"E10","source":"Crossref","is-referenced-by-count":58,"title":["Stereotactic spine radiosurgery for intradural and intramedullary metastasis"],"prefix":"10.3171","volume":"27","author":[{"given":"Dong Ah","family":"Shin","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, CHA University, Pochon, Republic of Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ryoong","family":"Huh","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA University, Pochon, Republic of Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sang Sup","family":"Chung","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, CHA University, Pochon, Republic of Korea; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jack","family":"Rock","sequence":"additional","affiliation":[{"name":"Neurosurgery, Henry Ford Hospital, Detroit, Michigan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Samuel","family":"Ryu","sequence":"additional","affiliation":[{"name":"Neurosurgery, Henry Ford Hospital, Detroit, Michigan"},{"name":"Departments of Radiation Oncology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"3 Suppl","key":"b1-0270010","series-title":"J Neurosurg","first-page":"413","article-title":"Safety and efficacy of stereotactic radiosurgery for tumors of the spine","volume":"101","author":"Benzil","year":"2004"},{"key":"b2-0270010","series-title":"Surg Neurol","first-page":"329","article-title":"Intramedullary spinal cord metastasis: report of three cases and review of the literature","volume":"46","author":"Connolly","year":"1996"},{"key":"b3-0270010","series-title":"Clin Neurol Neurosurg","first-page":"10","article-title":"Retrospective study of 19 patients with intramedullary spinal cord metastasis","volume":"111","author":"Dam-Hieu","year":"2009"},{"issue":"3 Suppl","key":"b4-0270010","series-title":"J Neurosurg","first-page":"435","article-title":"Spinal lesions treated with Novalis shaped beam intensity-modulated radiosurgery and stereotactic radiotherapy","volume":"101","author":"De Salles","year":"2004"},{"key":"b5-0270010","series-title":"Cancer Control","first-page":"405","article-title":"Spinal radiosurgery for 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metastases","volume":"75","author":"Mut","year":"2005"},{"key":"b10-0270010","series-title":"Clin Neurol Neurosurg","first-page":"152","article-title":"Successful removal of solitary intramedullary spinal cord metastasis from colon cancer","volume":"104","author":"Ogino","year":"2002"},{"key":"b11-0270010","series-title":"Anticancer Res","first-page":"3057","article-title":"Intrathecal chemotherapy in carcinomatous meningitis from breast cancer","volume":"22","author":"Orlando","year":"2002"},{"key":"b12-0270010","series-title":"Neurosurg Clin N Am","first-page":"503","article-title":"Novalis radiosurgery for metastatic spine tumors","volume":"15","author":"Rock","year":"2004"},{"key":"b13-0270010","series-title":"J Neurooncol","first-page":"319","article-title":"The evolving role of stereotactic radiosurgery and stereotactic radiation therapy for patients with spine 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