{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T11:54:37Z","timestamp":1787313277389,"version":"build-2736575974"},"reference-count":52,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2010,4]]},"abstract":"\n Object<\/jats:title>\n Although the transsphenoidal approach for subdiaphragmatic craniopharyngiomas has been performed for many years, there are few reports describing the role of the endoscopic transsphenoidal technique for suprasellar craniopharyngiomas. The purpose of this study was to report the outcomes of the endoscopic transsphenoidal approach for adults with craniopharyngiomas in whom the goal was gross-total resection.<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n Twelve patients were identified who were older than 18 years at the time of their pure endoscopic transsphenoidal surgery. Their medical records and imaging studies were retrospectively reviewed.<\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n Gross-total resection was achieved in 42% of cases when assessed by intraoperative impression alone and in 75% when assessed by the first postoperative MR imaging study. However, 83% of patients achieved at least a 95% resection when assessed by both intraoperative impression and the first postoperative MR imaging study. Permanent diabetes insipidus occurred postoperatively in 44% of patients. Six (67%) of 9 patients who had a functioning hypothalamic-pituitary axis preoperatively developed panhypopituitarism after surgery. Visual improvement or normalization occurred in 78% of patients with preoperative visual deficits. Although no patient experienced a postoperative CSF leak, 1 patient was treated for meningitis.<\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n The authors have achieved a high rate of radical resection and symptomatic improvement with the endoscopic transsphenoidal technique for both subdiaphragmatic (sellar\/suprasellar) and supradiaphragmatic (suprasellar) craniopharyngiomas. However, this is also associated with a high incidence of new endocrinopathy. Endoscopic assessment of tumor resection may be more sensitive for residual tumor than the first postoperative MR imaging study.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2010.1.focus09319","type":"journal-article","created":{"date-parts":[[2010,4,1]],"date-time":"2010-04-01T10:49:45Z","timestamp":1270118985000},"page":"E9","source":"Crossref","is-referenced-by-count":88,"title":["Early outcomes of endoscopic transsphenoidal surgery for adult craniopharyngiomas"],"prefix":"10.3171","volume":"28","author":[{"given":"John A.","family":"Jane","sequence":"first","affiliation":[{"name":"Department of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erin","family":"Kiehna","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Spencer C.","family":"Payne","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Stephen V.","family":"Early","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology\u2013Head and Neck Surgery, University of Virginia Health System, Charlottesville, Virginia; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward R.","family":"Laws","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0280009","series-title":"J Neurosurg","first-page":"650","article-title":"Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma","volume":"102","author":"Chakrabarti","year":"2005"},{"key":"b2-0280009","series-title":"Neurosurgery","first-page":"539","article-title":"Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases","volume":"55","author":"Couldwell","year":"2004"},{"issue":"5 Suppl 2","key":"b3-0280009","series-title":"Neurosurgery","first-page":"219","article-title":"Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas","volume":"61","author":"de Divitiis","year":"2007"},{"key":"b4-0280009","series-title":"Neurosurgery","first-page":"46","article-title":"Extended endoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors: part 2","volume":"60","author":"de Divitiis","year":"2007"},{"key":"b5-0280009","series-title":"J Neurosurg","first-page":"832","article-title":"The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors","volume":"102","author":"Dusick","year":"2005"},{"key":"b6-0280009","series-title":"Surg Neurol","first-page":"482","article-title":"Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas","volume":"70","author":"Dusick","year":"2008"},{"key":"b7-0280009","series-title":"J Neurosurg","first-page":"237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999"},{"issue":"1 Suppl 1","key":"b8-0280009","series-title":"Neurosurgery","first-page":"ONS75","article-title":"The endoscopic extended transsphenoidal approach for craniopharyngiomas","volume":"59","author":"Frank","year":"2006"},{"key":"b9-0280009","series-title":"J Neurosurg","first-page":"6","article-title":"Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series","volume":"109","author":"Gardner","year":"2008"},{"key":"b10-0280009","series-title":"J Neurosurg","first-page":"1043","article-title":"The evolution of the endonasal approach for craniopharyngiomas","volume":"108","author":"Gardner","year":"2008"},{"key":"b11-0280009","series-title":"J Neurosurg","first-page":"582","article-title":"Transsphenoidal hypophysectomy","volume":"34","author":"Hardy","year":"1971"},{"issue":"Suppl 1","key":"b12-0280009","series-title":"Pediatr Neurosurg","first-page":"44","article-title":"Surgical management of craniopharyngioma","volume":"21","author":"Hoffman","year":"1994"},{"key":"b13-0280009","series-title":"J Neurosurg","first-page":"47","article-title":"Aggressive surgical management of craniopharyngiomas in children","volume":"76","author":"Hoffman","year":"1992"},{"key":"b14-0280009","series-title":"J Neurosurg","first-page":"251","article-title":"Surgical treatment of craniopharyngiomas: endocrinological results","volume":"90","author":"Honegger","year":"1999"},{"key":"b15-0280009","series-title":"Surg Neurol","first-page":"189","article-title":"Transsphenoidal microsurgery for craniopharyngioma","volume":"37","author":"Honegger","year":"1992"},{"key":"b16-0280009","series-title":"Neurosurgery","first-page":"94","article-title":"Transsphenoidal approaches for the extracapsular resection of midline suprasellar and anterior cranial base lesions","volume":"49","author":"Kaptain","year":"2001"},{"issue":"1 Suppl 1","key":"b17-0280009","series-title":"Neurosurgery","first-page":"ONS44","article-title":"Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap","volume":"63","author":"Kassam","year":"2008"},{"key":"b18-0280009","series-title":"Surg Neurol","first-page":"290","article-title":"Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic translamina terminalis approach","volume":"71","author":"Kitano","year":"2009"},{"key":"b19-0280009","series-title":"J Neurosurg","first-page":"661","article-title":"Transsphenoidal microsurgery in the management of craniopharyngioma","volume":"52","author":"Laws","year":"1980"},{"issue":"Suppl 1","key":"b20-0280009","series-title":"Pediatr Neurosurg","first-page":"57","article-title":"Transsphenoidal removal of craniopharyngioma","volume":"21","author":"Laws","year":"1994"},{"issue":"5 Suppl 2","key":"b21-0280009","series-title":"Neurosurgery","first-page":"ONSE342","article-title":"\u201cGasket-seal\u201d watertight closure in minimal-access endoscopic cranial base surgery","volume":"62","author":"Leng","year":"2008"},{"key":"b22-0280009","series-title":"Neurosurgery","first-page":"715","article-title":"Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches","volume":"36","author":"Maira","year":"1995"},{"key":"b23-0280009","series-title":"Clin Neurosurg","first-page":"226","article-title":"The endoscopic endonasal transsphenoidal approach to the suprasellar cistern","volume":"54","author":"Schwartz","year":"2007"},{"key":"b24-0280009","series-title":"Childs Nerv Syst","first-page":"397","article-title":"Long-term results of treatment for craniopharyngioma in children","volume":"13","author":"Villani","year":"1997"},{"key":"b25-0280009","series-title":"Surgery of the Third Ventricle","first-page":"476","article-title":"The transnasal transsphenoidal approach","author":"Weiss","year":"1987"},{"key":"b26-0280009","series-title":"J Neurosurg","first-page":"3","article-title":"Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients","volume":"73","author":"Ya\u015fargil","year":"1990"},{"key":"b1-0280009","series-title":"J Neurosurg","first-page":"650","article-title":"Long-term neurological, visual, and endocrine outcomes following transnasal resection of craniopharyngioma","volume":"102","author":"Chakrabarti","year":"2005"},{"key":"b2-0280009","series-title":"Neurosurgery","first-page":"539","article-title":"Variations on the standard transsphenoidal approach to the sellar region, with emphasis on the extended approaches and parasellar approaches: surgical experience in 105 cases","volume":"55","author":"Couldwell","year":"2004"},{"issue":"5 Suppl 2","key":"b3-0280009","series-title":"Neurosurgery","first-page":"219","article-title":"Extended endoscopic transsphenoidal approach for extrasellar craniopharyngiomas","volume":"61","author":"de Divitiis","year":"2007"},{"key":"b4-0280009","series-title":"Neurosurgery","first-page":"46","article-title":"Extended endoscopic endonasal transsphenoidal approach for the removal of suprasellar tumors: part 2","volume":"60","author":"de Divitiis","year":"2007"},{"key":"b5-0280009","series-title":"J Neurosurg","first-page":"832","article-title":"The extended direct endonasal transsphenoidal approach for nonadenomatous suprasellar tumors","volume":"102","author":"Dusick","year":"2005"},{"key":"b6-0280009","series-title":"Surg Neurol","first-page":"482","article-title":"Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas","volume":"70","author":"Dusick","year":"2008"},{"key":"b7-0280009","series-title":"J Neurosurg","first-page":"237","article-title":"Surgical treatment of craniopharyngiomas: experience with 168 patients","volume":"90","author":"Fahlbusch","year":"1999"},{"issue":"1 Suppl 1","key":"b8-0280009","series-title":"Neurosurgery","first-page":"ONS75","article-title":"The endoscopic extended transsphenoidal approach for craniopharyngiomas","volume":"59","author":"Frank","year":"2006"},{"key":"b9-0280009","series-title":"J Neurosurg","first-page":"6","article-title":"Outcomes following endoscopic, expanded endonasal resection of suprasellar craniopharyngiomas: a case series","volume":"109","author":"Gardner","year":"2008"},{"key":"b10-0280009","series-title":"J Neurosurg","first-page":"1043","article-title":"The evolution of the endonasal approach for craniopharyngiomas","volume":"108","author":"Gardner","year":"2008"},{"key":"b11-0280009","series-title":"J Neurosurg","first-page":"582","article-title":"Transsphenoidal hypophysectomy","volume":"34","author":"Hardy","year":"1971"},{"issue":"Suppl 1","key":"b12-0280009","series-title":"Pediatr Neurosurg","first-page":"44","article-title":"Surgical management of craniopharyngioma","volume":"21","author":"Hoffman","year":"1994"},{"key":"b13-0280009","series-title":"J Neurosurg","first-page":"47","article-title":"Aggressive surgical management of craniopharyngiomas in children","volume":"76","author":"Hoffman","year":"1992"},{"key":"b14-0280009","series-title":"J Neurosurg","first-page":"251","article-title":"Surgical treatment of craniopharyngiomas: endocrinological results","volume":"90","author":"Honegger","year":"1999"},{"key":"b15-0280009","series-title":"Surg Neurol","first-page":"189","article-title":"Transsphenoidal microsurgery for craniopharyngioma","volume":"37","author":"Honegger","year":"1992"},{"key":"b16-0280009","series-title":"Neurosurgery","first-page":"94","article-title":"Transsphenoidal approaches for the extracapsular resection of midline suprasellar and anterior cranial base lesions","volume":"49","author":"Kaptain","year":"2001"},{"issue":"1 Suppl 1","key":"b17-0280009","series-title":"Neurosurgery","first-page":"ONS44","article-title":"Endoscopic reconstruction of the cranial base using a pedicled nasoseptal flap","volume":"63","author":"Kassam","year":"2008"},{"key":"b18-0280009","series-title":"Surg Neurol","first-page":"290","article-title":"Extended transsphenoidal surgery for suprasellar craniopharyngiomas: infrachiasmatic radical resection combined with or without a suprachiasmatic translamina terminalis approach","volume":"71","author":"Kitano","year":"2009"},{"key":"b19-0280009","series-title":"J Neurosurg","first-page":"661","article-title":"Transsphenoidal microsurgery in the management of craniopharyngioma","volume":"52","author":"Laws","year":"1980"},{"issue":"Suppl 1","key":"b20-0280009","series-title":"Pediatr Neurosurg","first-page":"57","article-title":"Transsphenoidal removal of craniopharyngioma","volume":"21","author":"Laws","year":"1994"},{"issue":"5 Suppl 2","key":"b21-0280009","series-title":"Neurosurgery","first-page":"ONSE342","article-title":"\u201cGasket-seal\u201d watertight closure in minimal-access endoscopic cranial base surgery","volume":"62","author":"Leng","year":"2008"},{"key":"b22-0280009","series-title":"Neurosurgery","first-page":"715","article-title":"Surgical treatment of craniopharyngiomas: an evaluation of the transsphenoidal and pterional approaches","volume":"36","author":"Maira","year":"1995"},{"key":"b23-0280009","series-title":"Clin Neurosurg","first-page":"226","article-title":"The endoscopic endonasal transsphenoidal approach to the suprasellar cistern","volume":"54","author":"Schwartz","year":"2007"},{"key":"b24-0280009","series-title":"Childs Nerv Syst","first-page":"397","article-title":"Long-term results of treatment for craniopharyngioma in children","volume":"13","author":"Villani","year":"1997"},{"key":"b25-0280009","series-title":"Surgery of the Third Ventricle","first-page":"476","article-title":"The transnasal transsphenoidal approach","author":"Weiss","year":"1987"},{"key":"b26-0280009","series-title":"J Neurosurg","first-page":"3","article-title":"Total removal of craniopharyngiomas. Approaches and long-term results in 144 patients","volume":"73","author":"Ya\u015fargil","year":"1990"}],"container-title":["Neurosurgical Focus"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/28\/4\/article-pE9.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/28\/4\/article-pE9.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/neurosurg-focus\/28\/4\/article-pE9.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2026,6,6]],"date-time":"2026-06-06T08:17:57Z","timestamp":1780733877000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/neurosurg-focus\/28\/4\/article-pE9.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,4]]},"references-count":52,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2010.1.focus09319","relation":{},"ISSN":["1092-0684"],"issn-type":[{"value":"1092-0684","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,4]]}}}