{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,16]],"date-time":"2026-02-16T19:30:48Z","timestamp":1771270248622,"version":"3.50.1"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:p>Malignant ectomesenchymoma is a rare tumor arising from mature ganglion cells with immature myogenous elements, with only 4 pediatric intracranial cases having been previously reported. The authors report a rare case of intracranial malignant ectomesenchymoma originating from the falx cerebri in a 10-year-old boy. The patient presented with a 2-week history of headache, nausea, and blurry vision, with mild lateral gaze diplopia. A CT scan revealed a solitary 7.2 \u00d7 3.8\u2013cm dural-based mass that extended along the falx. No metastatic disease was identified, and the lesion was grossly resected without complication. Pathological investigation identified single and small groups of cells in a myxoid background, with polygonal or spindle-shaped cells containing eccentric nuclei and prominent nucleoli. Immunohistochemical staining of some cells was positive for smooth-muscle actin, CD99, and vimentin, whereas other cells (often process forming) were positive for S100 protein, synaptophysin, and neurofilament protein. Staining was negative for CD138, CD45, \u03b1-fetoprotein, CK AE1\/3, glial fibrillary acidic protein, CK7, CK20, CD31, CD34, myoD, and desmin. Normal immunopositivity was seen for INI-1. The Ki 67 immunostaining had &lt; 25% reactivity. The patient was treated with a sarcoma-based chemotherapy regimen and radiation to the craniospinal axis, and was found to be without recurrence or metastatic disease at 20 months.<\/jats:p>","DOI":"10.3171\/2010.10.peds10261","type":"journal-article","created":{"date-parts":[[2010,12,31]],"date-time":"2010-12-31T14:36:41Z","timestamp":1293806201000},"page":"94-97","source":"Crossref","is-referenced-by-count":11,"title":["A rare case of malignant pediatric ectomesenchymoma arising from the falx cerebri"],"prefix":"10.3171","volume":"7","author":[{"given":"Dana L.","family":"Altenburger","sequence":"first","affiliation":[{"name":"Department of Pathology, Orlando Health;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aaron S.","family":"Wagner","sequence":"additional","affiliation":[{"name":"Section of Neuropathology, Department of Pathology and Laboratory Medicine and Neurology, University of California, Los Angeles, California"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Don E.","family":"Eslin","sequence":"additional","affiliation":[{"name":"Center for Children's Cancer and Blood Disorders, Arnold Palmer Hospital for Children, M. D. Anderson Cancer Center;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gary S.","family":"Pearl","sequence":"additional","affiliation":[{"name":"Department of Pathology, Orlando Health;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jogi V.","family":"Pattisapu","sequence":"additional","affiliation":[{"name":"Pediatric Neurosurgery, Arnold Palmer Hospital for Children, Orlando, Florida; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0070094","series-title":"Pediatr Dev Pathol","doi-asserted-by":"publisher","first-page":"290","DOI":"10.1007\/s100249910039","article-title":"Clinicopathologic study of ectomesenchymomas from Intergroup Rhabdomyosarcoma Study Groups III and IV","volume":"3","author":"Bou\u00e9","year":"2000"},{"key":"b2-0070094","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"320","DOI":"10.1159\/000028818","article-title":"Malignant ectomesenchymoma. 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