{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,5]],"date-time":"2026-01-05T22:21:36Z","timestamp":1767651696239},"reference-count":12,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,5]]},"abstract":"<jats:p>Although shunt placement constitutes the primary treatment for idiopathic normal pressure hydrocephalus (INPH), it has been challenging to decide which patients to refer for such an intervention. Procedures involving CSF removal, such as large-volume lumbar puncture (LP) and external lumbar drainage, are commonly used to predict a successful response to surgery, but their positive and negative predictive values have considerable shortcomings. The authors here report the case of a 76-year-old woman with possible INPH whose condition improved equally well after actual and sham large-volume LPs. The authors discuss the implications of this placebo response in the context of the diagnosis and management of INPH. The authors suggest that the clinical response to sham procedures for CSF removal might provide important information for better predicting which patient might respond to shunt surgery.<\/jats:p>","DOI":"10.3171\/2010.12.jns10106","type":"journal-article","created":{"date-parts":[[2011,1,21]],"date-time":"2011-01-21T14:53:01Z","timestamp":1295621581000},"page":"1428-1431","source":"Crossref","is-referenced-by-count":16,"title":["Potential placebo effect in assessing idiopathic normal pressure hydrocephalus"],"prefix":"10.3171","volume":"114","author":[{"given":"Amitabh","family":"Gupta","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anthony E.","family":"Lang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"3 Suppl","key":"b1-jns10106","series-title":"Neurosurgery","first-page":"S40","article-title":"Outcome of shunting in idiopathic normal-pressure hydrocephalus and the value of outcome assessment in shunted patients","volume":"57","author":"Klinge","year":"2005"},{"issue":"3 Suppl","key":"b2-jns10106","series-title":"Neurosurgery","first-page":"S17","article-title":"The value of supplemental prognostic tests for the preoperative assessment of idiopathic normal-pressure hydrocephalus","volume":"57","author":"Marmarou","year":"2005"},{"key":"b3-jns10106","series-title":"J Neurosurg","first-page":"987","article-title":"Diagnosis and management of idiopathic normal-pressure hydrocephalus: a prospective study in 151 patients","volume":"102","author":"Marmarou","year":"2005"},{"key":"b4-jns10106","series-title":"Neurosurgery","first-page":"699","article-title":"Diagnosis, treatment, and analysis of longterm outcomes in idiopathic normal-pressure hydrocephalus","volume":"57","author":"McGirt","year":"2005"},{"key":"b5-jns10106","series-title":"J Am Geriatr Soc","first-page":"695","article-title":"The Montreal Cognitive Assessment, MoCA: a brief screening tool for mild cognitive impairment","volume":"53","author":"Nasreddine","year":"2005"},{"key":"b6-jns10106","series-title":"Clin Neurol Neurosurg","first-page":"455","article-title":"Features of gait most responsive to tap test in normal pressure hydrocephalus","volume":"110","author":"Ravdin","year":"2008"},{"issue":"3 Suppl","key":"b7-jns10106","series-title":"Neurosurgery","first-page":"S4","article-title":"Diagnosing idiopathic normal-pressure hydrocephalus","volume":"57","author":"Relkin","year":"2005"},{"key":"b8-jns10106","series-title":"J Am Geriatr Soc","first-page":"2044","article-title":"A comparison of gait assessment methods: Tinetti and GAITRite electronic walkway","volume":"53","author":"Shore","year":"2005"},{"key":"b9-jns10106","series-title":"Curr Neurol Neurosci Rep","first-page":"371","article-title":"Normal pressure hydrocephalus: diagnosis and treatment","volume":"8","author":"Shprecher","year":"2008"},{"key":"b10-jns10106","series-title":"J Eval Clin Pract","first-page":"77","article-title":"Patient expectations in placebo-controlled randomized clinical trials","volume":"11","author":"Stone","year":"2005"},{"key":"b11-jns10106","series-title":"Dement Geriatr Cogn Disord","first-page":"163","article-title":"Baseline neuropsychological profile and cognitive response to cerebrospinal fluid shunting for idiopathic normal pressure hydrocephalus","volume":"20","author":"Thomas","year":"2005"},{"key":"b12-jns10106","series-title":"J Am Geriatr Soc","first-page":"119","article-title":"Performance-oriented assessment of mobility problems in elderly patients","volume":"34","author":"Tinetti","year":"1986"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/5\/article-p1428.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/5\/article-p1428.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/5\/article-p1428.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:47:17Z","timestamp":1679899637000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/5\/article-p1428.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2011,5]]},"references-count":12,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2010.12.jns10106","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,5]]}}}