{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,11]],"date-time":"2026-07-11T13:14:52Z","timestamp":1783775692777,"version":"3.55.0"},"reference-count":80,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Although there is a considerable volume of literature available on the treatment of patients with cavernous sinus meningiomas (CSMs), most of the data regarding tumor control and survival come from case studies or single-institution series. The authors performed a meta-analysis of reported tumor control and survival rates of patients described in the published literature, with an emphasis on specific prognostic factors.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors systematically analyzed the published literature and found more than 3000 patients treated for CSMs. Separate meta-analyses were performed to calculate pooled rates of recurrence and cranial neuropathy after 1) gross-total resection, 2) subtotal resection without adjuvant postoperative radiotherapy or radiosurgery, and 3) stereotactic radiosurgery (SRS) alone. Results were expressed as pooled proportions, and random-effects models were used to incorporate any heterogeneity present to generate a pooled proportion. Individual studies were weighted using the inverse variance method, and 95% CIs for each group were calculated from the pooled proportions.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>A total of 2065 nonduplicated patients treated for CSM met inclusion criteria for the analysis. Comparisons of the 95% CIs for recurrence of these 3 cohorts revealed that SRS-treated patients experienced improved rates of recurrence (3.2% [95% CI 1.9\u20134.5%]) compared with either gross-total resection (11.8% [95% CI 7.4\u201316.1%]) or subtotal resection alone (11.1% [95% CI 6.6\u201315.7%]) (p &lt; 0.01). The authors found that the pooled mixed-effects rate of cranial neuropathy was markedly higher in patients undergoing resection (59.6% [95% CI 50.3\u201367.5%]) than for those undergoing SRS alone (25.7% [95% CI 11.5\u201338.9%]) (p &lt; 0.05).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Radiosurgery provided improved rates of tumor control compared with surgery alone, regardless of the subjective extent of resection.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.3.jns091807","type":"journal-article","created":{"date-parts":[[2010,5,7]],"date-time":"2010-05-07T14:19:43Z","timestamp":1273241983000},"page":"1087-1092","source":"Crossref","is-referenced-by-count":61,"title":["Factors affecting outcome following treatment of patients with cavernous sinus meningiomas"],"prefix":"10.3171","volume":"113","author":[{"given":"Michael E.","family":"Sughrue","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martin J.","family":"Rutkowski","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Derick","family":"Aranda","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Igor J.","family":"Barani","sequence":"additional","affiliation":[{"name":"Radiation Oncology, University of California at San Francisco, California"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael W.","family":"McDermott","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andrew T.","family":"Parsa","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns091807","series-title":"Stereotact Funct Neurosurg","first-page":"303","article-title":"Internal carotid occlusion following gamma knife radiosurgery for cavernous sinus meningioma","volume":"85","author":"Abeloos","year":"2007"},{"issue":"3 Suppl","key":"b2-jns091807","series-title":"Neurosurgery","first-page":"1115","article-title":"Surgery for extra-axial tumors of the cerebral convexity and midline","volume":"62","author":"Black","year":"2008"},{"key":"b3-jns091807","series-title":"Surg Neurol","first-page":"28","article-title":"Fractionated stereotactic radiotherapy in the treatment of exclusive cavernous sinus meningioma: functional outcome, local control, and tolerance","volume":"65","author":"Brell","year":"2006"},{"key":"b4-jns091807","series-title":"Stereotact Funct Neurosurg","first-page":"43","article-title":"LINAC radiosurgery for cavernous sinus meningiomas","volume":"71","author":"Chang","year":"1998"},{"key":"b5-jns091807","series-title":"Neurochirurgia (Stuttg)","first-page":"40","article-title":"Cavernous sinus meningiomas","volume":"30","author":"Cioffi","year":"1987"},{"key":"b6-jns091807","series-title":"J Neurosurg","first-page":"148","article-title":"Decompression of cavernous sinus meningioma for preservation and improvement of cranial nerve function. 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approach to intracavernous tumors","volume":"28","author":"Lesoin","year":"1987"},{"key":"b43-jns091807","series-title":"Acta Neurochir (Wien)","first-page":"473","article-title":"Gamma knife radiosurgery of meningiomas in the cavernous sinus region","volume":"141","author":"Lisc\u00e1k","year":"1999"},{"key":"b44-jns091807","series-title":"Int J Radiat Oncol Biol Phys","first-page":"75","article-title":"Fractionated external-beam radiation therapy for meningiomas of the cavernous sinus","volume":"44","author":"Maguire","year":"1999"},{"key":"b45-jns091807","series-title":"Br J Neurosurg","first-page":"13","article-title":"The use of stereotactic radiosurgery in the management of meningiomas","volume":"19","author":"Malik","year":"2005"},{"key":"b46-jns091807","series-title":"Neurosurgery","first-page":"1068","article-title":"Proposed treatment strategy for cavernous sinus meningiomas: a prospective 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meningiomas: experience in 88 patients","volume":"90","author":"Morita","year":"1999"},{"key":"b51-jns091807","series-title":"J Clin Neurosci","first-page":"301","article-title":"Petroclival mixed meningioma","volume":"12","author":"Muzumdar","year":"2005"},{"key":"b52-jns091807","series-title":"Acta Neurochir (Wien)","first-page":"891","article-title":"Two-stage skull base surgery for tumours extending to the sub- and epidural spaces","volume":"140","author":"Nakase","year":"1998"},{"key":"b53-jns091807","series-title":"Neurosurgery","first-page":"1153","article-title":"Radiosurgical treatment of cavernous sinus meningiomas: experience with 122 treated patients","volume":"51","author":"Nicolato","year":"2002"},{"key":"b54-jns091807","series-title":"Int J Radiat Oncol Biol Phys","first-page":"992","article-title":"The role of Gamma Knife radiosurgery in the management of cavernous sinus meningiomas","volume":"53","author":"Nicolato","year":"2002"},{"key":"b55-jns091807","series-title":"Neurosurgery","first-page":"238","article-title":"The surgical resectability of meningiomas of the cavernous sinus","volume":"40","author":"O'Sullivan","year":"1997"},{"issue":"2 Suppl","key":"b56-jns091807","series-title":"Surg Neurol","first-page":"S58","article-title":"Changing treatment strategy of cavernous sinus meningiomas: experience of a single institution","volume":"64","author":"Pamir","year":"2005"},{"key":"b57-jns091807","series-title":"Surv Ophthalmol","first-page":"354","article-title":"Here today\u2026 gone tomorrow","volume":"41","author":"Phillips","year":"1997"},{"key":"b58-jns091807","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1427","article-title":"Results of stereotactic radiosurgery for patients with imaging defined cavernous sinus meningiomas","volume":"62","author":"Pollock","year":"2005"},{"key":"b59-jns091807","series-title":"Otolaryngol Head Neck Surg","first-page":"519","article-title":"Extended orbitozygomatic approach to the skull base to improve access to the cavernous sinus and optic chiasm","volume":"130","author":"Pontius","year":"2004"},{"issue":"3 Suppl","key":"b60-jns091807","series-title":"J Neurosurg","first-page":"68","article-title":"Gamma knife radiosurgery in the management of cavernous sinus meningiomas","volume":"93","author":"Roche","year":"2000"},{"key":"b61-jns091807","series-title":"Arch Neurol","first-page":"29","article-title":"Primary aberrant aculomotor regeneration. A sign of intracavernous meningioma","volume":"34","author":"Schatz","year":"1977"},{"key":"b62-jns091807","series-title":"Int J Radiat Oncol Biol Phys","first-page":"781","article-title":"Computer systems and mechanical tools for stereotactically guided conformation therapy with linear accelerators","volume":"24","author":"Schlegel","year":"1992"},{"key":"b63-jns091807","series-title":"Neurosurgery","first-page":"18","article-title":"Surgical treatment of intracavernous neoplasms: a four-year experience","volume":"24","author":"Sekhar","year":"1989"},{"key":"b64-jns091807","series-title":"Int J Radiat Oncol Biol Phys","first-page":"101","article-title":"Stereotactic radiotherapy for treatment of cavernous sinus meningiomas","volume":"59","author":"Selch","year":"2004"},{"key":"b65-jns091807","series-title":"J Neurosurg","first-page":"535","article-title":"Meningiomas involving the cavernous sinus: histological factors affecting the degree of resection","volume":"87","author":"Sen","year":"1997"},{"key":"b66-jns091807","series-title":"Acta Neurochir Suppl (Wien)","doi-asserted-by":"crossref","first-page":"122","DOI":"10.1007\/978-3-7091-9183-5_21","article-title":"Management of intracavernous tumours: an 11-year experience","volume":"53","author":"Sepehrnia","year":"1991"},{"key":"b67-jns091807","series-title":"Surg Neurol","first-page":"167","article-title":"Invasion of the internal carotid artery by cavernous sinus meningiomas","volume":"52","author":"Shaffrey","year":"1999"},{"key":"b68-jns091807","series-title":"Clin Exp Optom","first-page":"132","article-title":"Pupil sparing incomplete third nerve palsy secondary to a cavernous sinus meningioma: challenges in management","volume":"90","author":"Shechtman","year":"2007"},{"key":"b69-jns091807","series-title":"J Neurosurg","first-page":"491","article-title":"Sphenoorbital meningiomas: surgical limitations and lessons learned in their long-term management","volume":"103","author":"Shrivastava","year":"2005"},{"key":"b70-jns091807","series-title":"Br J Neurosurg","first-page":"158","article-title":"Stereotactic radiosurgery. 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Radiosurgery versus conventionally-fractionated radiotherapy in the treatment of cavernous sinus meningiomas","volume":"13","author":"Sibtain","year":"1999"},{"key":"b71-jns091807","series-title":"J Neurol Neurosurg Psychiatry","first-page":"22","article-title":"The recurrence of intracranial meningiomas after surgical treatment","volume":"20","author":"Simpson","year":"1957"},{"key":"b72-jns091807","series-title":"J Neurosurg","first-page":"937","article-title":"Long-term follow-up of meningiomas of the cavernous sinus after surgical treatment alone","volume":"107","author":"Sindou","year":"2007"},{"key":"b73-jns091807","series-title":"Neurosurgery","first-page":"1373","article-title":"Linear accelerator radiosurgery for meningiomas in and around the cavernous sinus","volume":"51","author":"Spiegelmann","year":"2002"},{"key":"b74-jns091807","series-title":"Mayo Clin Proc","first-page":"936","article-title":"Primarily resected meningiomas: outcome and prognostic factors in 581 Mayo Clinic patients, 1978 through 1988","volume":"73","author":"Stafford","year":"1998"},{"key":"b75-jns091807","series-title":"Surg Neurol","first-page":"3","article-title":"Should meningiomas involving the cavernous sinus be totally resected?","volume":"44","author":"Suzuki","year":"1995"},{"key":"b76-jns091807","series-title":"Arch Ophthalmol","first-page":"457","article-title":"Meningiomas and aneurysms of the cavernous sinus. 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Case report","volume":"88","author":"van Overbeeke","year":"1998"},{"key":"b79-jns091807","series-title":"Can J Ophthalmol","first-page":"341","article-title":"Cavernous sinus meningioma presenting as intermittent exotropia in a 2-year-old girl","volume":"42","author":"White","year":"2007"},{"key":"b80-jns091807","series-title":"J Neurosurg","first-page":"640","article-title":"Cavernous sinus meningioma","volume":"96","author":"Ziyal","year":"2002"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/5\/article-p1087.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/5\/article-p1087.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/5\/article-p1087.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:52:51Z","timestamp":1679892771000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/5\/article-p1087.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":80,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2010.3.jns091807","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}