{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T17:21:15Z","timestamp":1789147275971,"version":"build-2803163510"},"reference-count":48,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Although cognitive impairment has been reported in adults with moyamoya disease (MMD), its relationship with cerebral hemodynamic disturbances has not been investigated. The aims of the present study were to confirm the presence of dysexecutive cognitive syndrome (DCS) in adults with MMD and to explore the relationship of DCS with frontal lobe perfusion as measured by perfusion MR imaging.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Cerebral blood volume (CBV) ratio and mean transit time delay were measured in frontal and temporoparietal regions using the cerebellum as a reference region in 10 European adults with MMD. In addition, the authors calculated the cerebrovascular reserve (CVR) using the CBV ratio and the acetazolamide challenge. All patients underwent a standardized neuropsychological assessment test battery. The authors defined DCS as an impairment shown on 3 tests or more of executive function.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The authors found DCS in 6 patients. The frontal CVR was lower in patients with DCS than in patients without DCS (mean \u00b1 SD: \u221213.5 \u00b1 13.2% and 20.3 \u00b1 21.3%; p = 0.019, Mann-Whitney U-test). Other parameters of frontal perfusion and temporoparietal CVR were not correlated with DCS.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The authors' findings suggest that DCS is common in European adults with MMD and may be related to frontal perfusion impairment.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.4.jns091808","type":"journal-article","created":{"date-parts":[[2010,5,14]],"date-time":"2010-05-14T14:06:34Z","timestamp":1273845994000},"page":"753-759","source":"Crossref","is-referenced-by-count":66,"title":["Correlation between cognitive impairment and cerebral hemodynamic disturbances on perfusion magnetic resonance imaging in European adults with moyamoya disease"],"prefix":"10.3171","volume":"113","author":[{"given":"Lionel","family":"Calviere","sequence":"first","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Isabelle","family":"Catalaa","sequence":"additional","affiliation":[{"name":"Neuroradiology, University of Toulouse, Rangueil Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabienne","family":"Marlats","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alain","family":"Viguier","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabrice","family":"Bonneville","sequence":"additional","affiliation":[{"name":"Neuroradiology, University of Toulouse, Rangueil Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christophe","family":"Cognard","sequence":"additional","affiliation":[{"name":"Neuroradiology, University of Toulouse, Rangueil Hospital, Toulouse, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vincent","family":"Larrue","sequence":"additional","affiliation":[{"name":"Departments of Neurology and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns091808","series-title":"Br J Psychiatry","first-page":"200","article-title":"Cognitive deficits in depression: possible implications for functional neuropathology","volume":"178","author":"Austin","year":"2001"},{"key":"b2-jns091808","series-title":"Neuroradiology","first-page":"1","article-title":"Can cerebrovascular reactivity be assessed by dynamic susceptibility contrast-enhanced MRI?","volume":"40","author":"Berthezene","year":"1998"},{"key":"b3-jns091808","series-title":"Int J Neurosci","first-page":"39","article-title":"Neuropsychological performance in Moya Moya disease: a case study","volume":"26","author":"Bornstein","year":"1985"},{"key":"b4-jns091808","series-title":"Evaluation Neuropsychologique","author":"Braun","year":"1997"},{"key":"b5-jns091808","series-title":"Magn Reson Med","first-page":"466","article-title":"Delay and dispersion effects in dynamic susceptibility contrast MRI: simulations using singular value decomposition","volume":"44","author":"Calamante","year":"2000"},{"key":"b6-jns091808","series-title":"Stroke","first-page":"1146","article-title":"Quantification of perfusion using bolus tracking magnetic resonance imaging in stroke: assumptions, limitations, and potential implications for clinical use","volume":"33","author":"Calamante","year":"2002"},{"key":"b7-jns091808","series-title":"Stroke","first-page":"2810","article-title":"MR perfusion imaging in Moyamoya Syndrome: potential implications for clinical evaluation of occlusive cerebrovascular disease","volume":"32","author":"Calamante","year":"2001"},{"key":"b8-jns091808","series-title":"Rev Neurol (Paris)","first-page":"709","article-title":"[Clinical course and outcome in French adults with Moyamoya disease.]","volume":"165","author":"Calviere","year":"2009"},{"key":"b9-jns091808","series-title":"Acta Neurol Belg","first-page":"207","article-title":"[Formal and semantic lexical evocation in normal subjects. 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