{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:04:57Z","timestamp":1780131897252,"version":"3.54.0"},"reference-count":56,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2010,8]]},"abstract":"<jats:p>Intermittent explosive disorder (IED) is characterized by a dysfunction in the greater limbic system leading an individual to experience sudden aggressive behavior with little or no environmental perturbation. This report describes a procedure for the treatment of IED in a 19-year-old woman with a history of IED, having had episodes of severe violent attacks against family, dating to early childhood. Due to the severity and intractability of the illness, deep brain stimulation was performed, targeting the orbitofrontal projections to the hypothalamus. The patient's history and the procedure, management, and rationale are described in detail.<\/jats:p>","DOI":"10.3171\/2010.5.focus10102","type":"journal-article","created":{"date-parts":[[2010,7,30]],"date-time":"2010-07-30T09:36:14Z","timestamp":1280482574000},"page":"E11","source":"Crossref","is-referenced-by-count":25,"title":["Deep brain stimulation of the orbitofrontal projections for the treatment of intermittent explosive disorder"],"prefix":"10.3171","volume":"29","author":[{"given":"Jason H.","family":"Maley","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jorge E.","family":"Alvernia","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edison P.","family":"Valle","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Donald","family":"Richardson","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0290011","series-title":"Encephale","first-page":"339","article-title":"[Intermittent explosive disorder: current status.]","volume":"33","author":"Amara","year":"2007"},{"key":"b2-0290011","series-title":"Brain Res","doi-asserted-by":"publisher","first-page":"327","DOI":"10.1016\/0006-8993(79)91011-4","article-title":"Interspecies aggression in the rat: the role of the diagonal band of Broca","volume":"175","author":"Bandler","year":"1979"},{"key":"b3-0290011","series-title":"Psychopharmacology (Berl)","doi-asserted-by":"publisher","first-page":"24","DOI":"10.1007\/s002130050858","article-title":"The effects of tryptophan depletion and loading on laboratory aggression in men: time course and a food-restricted control","volume":"142","author":"Bjork","year":"1999"},{"key":"b4-0290011","series-title":"Soc Cogn Affect Neurosci","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1093\/scan\/nsn035","article-title":"Right ventromedial prefrontal cortex: a neuroanatomical correlate of impulse control in boys","volume":"4","author":"Boes","year":"2009"},{"key":"b5-0290011","series-title":"Harv Rev Psychiatry","doi-asserted-by":"publisher","first-page":"336","DOI":"10.3109\/10673229809003583","article-title":"Impulsive aggression: a behavior in search of clinical definition","volume":"5","author":"Coccaro","year":"1998"},{"key":"b6-0290011","series-title":"Curr Psychiatry Rep","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11920-004-0027-7","article-title":"Intermittent explosive disorder and impulsive aggression: the time for serious study is now","volume":"6","author":"Coccaro","year":"2004"},{"key":"b7-0290011","series-title":"Science","doi-asserted-by":"publisher","first-page":"591","DOI":"10.1126\/science.289.5479.591","article-title":"Dysfunction in the neural circuitry of emotion regulation\u2014a possible prelude to violence","volume":"289","author":"Davidson","year":"2000"},{"key":"b8-0290011","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"710","DOI":"10.3171\/jns.2007.106.4.710","article-title":"Historical evolution of stereotactic amygdalotomy for the management of severe aggression","volume":"106","author":"Fountas","year":"2007"},{"key":"b9-0290011","series-title":"Am J Psychiatry","doi-asserted-by":"publisher","first-page":"915","DOI":"10.1176\/appi.ajp.162.5.915","article-title":"Brain serotonin transporter distribution in subjects with impulsive aggressivity: a positron emission study with [11C]McN 5652","volume":"162","author":"Frankle","year":"2005"},{"key":"b10-0290011","series-title":"Stereotact Funct Neurosurg","doi-asserted-by":"publisher","first-page":"63","DOI":"10.1159\/000086675","article-title":"Stimulation of the posterior hypothalamus for medically intractable impulsive and violent behavior","volume":"83","author":"Franzini","year":"2005"},{"key":"b11-0290011","series-title":"Arch f d ges Physiol","first-page":"570","article-title":"Der Hund ohne Grosshirn. 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