{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2023,5,8]],"date-time":"2023-05-08T12:49:58Z","timestamp":1683550198103},"reference-count":33,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,2]]},"abstract":"\nObject<\/jats:title>\nEfficacy of radiosurgery in vestibular schwannoma (VS) is usually documented by changes of tumor size and by loss of contrast enhancement in MR imaging within the central portion of the lesion. Until now, however, correlation between contrast enhancement and timing of image acquisition in nontreated VS has not been analyzed systematically. The authors undertook this study to investigate changes in contrast enhancement with respect to latency of image acquisition after contrast agent administration.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe dynamics of contrast medium uptake were evaluated with T1-weighted VIBE MR imaging sequences performed immediately and 1.5, 3.5, 4.5, 9.5, and 11.5 minutes after administration of single dose of Gd in 21 patients with nontreated medium- to large-sized VSs. Signal-to-noise (SNR) and contrast-to-noise ratio (CNR) of tumors were evaluated, and volumes of central nonenhancing areas (NEAs) were determined.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThe interior appearance of the tumors changed considerably over time. The NEA significantly diminished in size (p < 0.0001, Friedman test) and almost completely disappeared in all but 2 patients. Compared to images at 1.5 minutes, NEA volumes decreased to a median of 36% at 3.5 minutes and 34% at 4.5 minutes, showing smaller changes after that\u20149% at 9.5 minutes and 3% at 11.5 minutes. Tumor SNR and CNR increased over time. The maximum change in the median values for SNR and CNR were a 72% increase and 117% increase, respectively; both occurred at 1.5 minutes after Gd administration.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nContrast enhancement in VS MR imaging varies according to the duration of the delay between contrast agent administration and image acquisition. Postradiotherapy changes in contrast enhancement of VS can therefore not be attributed only to effective radiotherapy. So-called \u201closs of central contrast enhancement\u201d may be falsely detected because of timing. A standardized protocol with defined timing of image acquisition may increase comparability of contrast uptake in VS.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.5.jns10307","type":"journal-article","created":{"date-parts":[[2010,6,4]],"date-time":"2010-06-04T14:46:38Z","timestamp":1275662798000},"page":"394-399","source":"Crossref","is-referenced-by-count":1,"title":["Magnetic resonance imaging dynamics of contrast medium uptake in vestibular schwannomas"],"prefix":"10.3171","volume":"114","author":[{"given":"Stefan","family":"Rampp","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Scheller","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Halle-Wittenberg, Halle; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Julian","family":"Prell","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Halle-Wittenberg, Halle; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tobias","family":"Engelhorn","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, University Erlangen-Nuremberg, Erlangen, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Christian","family":"Strauss","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Halle-Wittenberg, Halle; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jens","family":"Rachinger","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, University of Halle-Wittenberg, Halle; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns10307","series-title":"Proc Natl Acad Sci U S A","first-page":"8443","article-title":"A model for MRI contrast enhancement using T1 agents","volume":"95","author":"Ahrens","year":"1998"},{"key":"b2-jns10307","series-title":"Acta Neurochir (Wien)","first-page":"689","article-title":"Gamma knife radiosurgery of acoustic neurinomas","volume":"143","author":"Bertalanffy","year":"2001"},{"key":"b3-jns10307","series-title":"Eur Radiol","first-page":"2472","article-title":"Imaging of cerebellopontine angle lesions: an update. Part 1: enhancing extra-axial lesions","volume":"17","author":"Bonneville","year":"2007"},{"key":"b4-jns10307","series-title":"Acta Otolaryngol Suppl","first-page":"11","article-title":"Cystic vestibular schwannoma\u2014clinical and experimental studies","volume":"543","author":"Charabi","year":"2000"},{"issue":"Suppl","key":"b5-jns10307","series-title":"J Neurosurg","first-page":"87","article-title":"Gamma knife surgery for vestibular schwannoma: 10-year experience of 195 cases","volume":"102","author":"Chung","year":"2005"},{"key":"b6-jns10307","series-title":"Neurochirurgie","first-page":"401","article-title":"[Cystic vestibular schwannomas.]","volume":"50","author":"Delsanti","year":"2004"},{"key":"b7-jns10307","series-title":"Radiother Oncol","first-page":"215","article-title":"Dose and diameter relationships for facial, trigeminal, and acoustic neuropathies following acoustic neuroma radiosurgery","volume":"41","author":"Flickinger","year":"1996"},{"key":"b8-jns10307","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1153","article-title":"Stereotactic radiosurgery using the gamma knife for acoustic neuromas","volume":"32","author":"Foote","year":"1995"},{"key":"b9-jns10307","series-title":"Br J Neurosurg","first-page":"169","article-title":"Radiosurgery: a minimally interventional alternative to microsurgery in the management of acoustic neuroma","volume":"10","author":"Forster","year":"1996"},{"key":"b10-jns10307","series-title":"Zentralbl Neurochir","first-page":"204","article-title":"Hemorrhage into cystic vestibular schwannoma following stereotactic radiation therapy","volume":"69","author":"Ganslandt","year":"2008"},{"key":"b11-jns10307","series-title":"Otol Neurotol","first-page":"79","article-title":"Vestibular schwannomas: correlations between magnetic resonance imaging and histopathologic appearance","volume":"22","author":"Gomez-Brouchet","year":"2001"},{"key":"b12-jns10307","series-title":"Neurosurgery","first-page":"257","article-title":"Stereotactic radiosurgery for vestibular schwannomas: analysis of 317 patients followed more than 5 years","volume":"57","author":"Hasegawa","year":"2005"},{"key":"b13-jns10307","series-title":"Strahlenther Onkol","first-page":"567","article-title":"Comparison of stereotactic radiosurgery and fractionated stereotactic radiotherapy of acoustic neurinomas according to 3-D tumor volume shrinkage and quality of life","volume":"185","author":"Henzel","year":"2009"},{"issue":"2 Suppl 1","key":"b14-jns10307","series-title":"Neurosurgery","first-page":"ONS75","article-title":"Surgery after radiosurgery for acoustic neuromas: surgical strategy and histological findings","volume":"60","author":"Iwai","year":"2007"},{"key":"b15-jns10307","series-title":"J Cancer Res Ther","first-page":"8","article-title":"Long-term results of LINAC-based stereotactic radiosurgery for acoustic neuroma: the Greek experience","volume":"5","author":"Kalogeridi","year":"2009"},{"key":"b16-jns10307","series-title":"Acta Neurochir Suppl","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1007\/978-3-7091-9371-6_19","article-title":"The early effects of gamma knife on 40 cases of acoustic neurinoma","volume":"62","author":"Kobayashi","year":"1994"},{"key":"b17-jns10307","series-title":"N Engl J Med","first-page":"1426","article-title":"Long-term outcomes after radiosurgery for acoustic neuromas","volume":"339","author":"Kondziolka","year":"1998"},{"issue":"Suppl 1","key":"b18-jns10307","series-title":"Stereotact Funct Neurosurg","first-page":"2","article-title":"Radiologic and histopathologic changes after Gamma Knife radiosurgery for acoustic schwannoma","volume":"72","author":"Kwon","year":"1999"},{"key":"b19-jns10307","series-title":"Acta Chir Scand","first-page":"763","article-title":"A note on the treatment of acoustic tumours","volume":"137","author":"Leksell","year":"1971"},{"key":"b20-jns10307","series-title":"Neurochirurgie","first-page":"320","article-title":"[In vivo evaluation of tumor response to radiosurgery: application to vestibular schwannomas.]","volume":"50","author":"Levivier","year":"2004"},{"key":"b21-jns10307","series-title":"Neurosurgery","first-page":"294","article-title":"Gamma knife radiosurgery in younger patients with vestibular schwannomas","volume":"65","author":"Lobato-Polo","year":"2009"},{"issue":"Suppl","key":"b22-jns10307","series-title":"J Neurosurg","first-page":"195","article-title":"Radiosurgery of vestibular schwannomas: summary of experience in 829 cases","volume":"102","author":"Lunsford","year":"2005"},{"key":"b23-jns10307","series-title":"J Neurosurg","first-page":"1013","article-title":"Preliminary results of linear accelerator radiosurgery for acoustic schwannomas","volume":"85","author":"Mendenhall","year":"1996"},{"key":"b24-jns10307","series-title":"AJNR Am J Neuroradiol","first-page":"1540","article-title":"Serial follow-up MR imaging after gamma knife radiosurgery for vestibular schwannoma","volume":"21","author":"Nakamura","year":"2000"},{"key":"b25-jns10307","series-title":"Acta Neurochir Suppl (Wien)","first-page":"104","article-title":"Gamma knife surgery in acoustic tumours","volume":"58","author":"Nor\u00e9n","year":"1993"},{"key":"b26-jns10307","series-title":"J Neurosurg","first-page":"53","article-title":"Linear accelerator radiosurgery for vestibular schwannoma: measuring tumor volume changes on serial three-dimensional spoiled gradient-echo magnetic resonance images","volume":"103","author":"Okunaga","year":"2005"},{"key":"b27-jns10307","series-title":"Neurosurgery","first-page":"241","article-title":"Management of vestibular schwannomas that enlarge after stereotactic radiosurgery: treatment recommendations based on a 15 year experience","volume":"58","author":"Pollock","year":"2006"},{"key":"b28-jns10307","series-title":"J Neurosurg","first-page":"745","article-title":"Gamma surgery for vestibular schwannoma","volume":"92","author":"Prasad","year":"2000"},{"key":"b29-jns10307","series-title":"Otolaryngol Clin North Am","first-page":"665","article-title":"Cyberknife radiotherapy for vestibular schwannoma","volume":"42","author":"Sakamoto","year":"2009"},{"key":"b30-jns10307","series-title":"Cen Eur Neurosurg","first-page":"35","article-title":"Contrast enhancement and histopathological findings in vestibular schwannoma","volume":"71","author":"Scheller","year":"2010"},{"issue":"Suppl 3","key":"b31-jns10307","series-title":"J Neurosurg","first-page":"362","article-title":"Stereotactic radiotherapy for the treatment of acoustic neuromas","volume":"101","author":"Selch","year":"2004"},{"key":"b32-jns10307","series-title":"Neurochirurgie","first-page":"327","article-title":"Histopathological observations on vestibular schwannomas after Gamma Knife radiosurgery: the Marseille experience","volume":"50","author":"Szeifert","year":"2004"},{"key":"b33-jns10307","series-title":"Invest Radiol","first-page":"558","article-title":"Brain tumor enhancement in MR imaging at 3 Tesla: comparison of SNR and CNR gain using TSE and GRE techniques","volume":"42","author":"Wintersperger","year":"2007"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/2\/article-p394.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/2\/article-p394.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/2\/article-p394.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:21:54Z","timestamp":1679898114000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/2\/article-p394.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":33,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2010.5.jns10307","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}