{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:15:18Z","timestamp":1780071318992,"version":"3.54.0"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>This is a retrospective review of 10,242 adults with degenerative spondylolisthesis (DS) and isthmic spondylolisthesis (IS) from the morbidity and mortality (M&amp;M) index of the Scoliosis Research Society (SRS). This database was reviewed to assess complication incidence, and to identify factors that were associated with increased complication rates.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The SRS M&amp;M database was queried to identify cases of DS and IS treated between 2004 and 2007. Complications were identified and analyzed based on age, surgical approach, spondylolisthesis type\/grade, and history of previous surgery. Age was stratified into 2 categories: &gt; 65 years and \u2264 65 years. Surgical approach was stratified into the following categories: decompression without fusion, anterior, anterior\/posterior, posterior without instrumentation, posterior with instrumentation, and interbody fusion. Spondylolisthesis grades were divided into low-grade (Meyerding I and II) versus high-grade (Meyerding III, IV, and V) groups. Both univariate and multivariate analyses were performed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>In the 10,242 cases of DS and IS reported, there were 945 complications (9.2%) in 813 patients (7.9%). The most common complications were dural tears, wound infections, implant complications, and neurological complications (range 0.7%\u20132.1%). The mortality rate was 0.1%. Diagnosis of DS had a significantly higher complication rate (8.5%) when compared with IS (6.6%; p = 0.002). High-grade spondylolisthesis correlated strongly with a higher complication rate (22.9% vs 8.3%, p &lt; 0.0001). Age &gt; 65 years was associated with a significantly higher complication rate (p = 0.02). History of previous surgery and surgical approach were not significantly associated with higher complication rates. On multivariate analysis, only the grade of spondylolisthesis (low vs high) was in the final best-fit model of factors associated with the occurrence of complications (p &lt; 0.0001).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The rate of total complications for treatment of DS and IS in this series was 9.2%. The total percentage of patients with complications was 7.9%. On univariate analysis, the complication rate was significantly higher in patients with high-grade spondylolisthesis, a diagnosis of DS, and in older patients. Surgical approach and history of previous surgery were not significantly correlated with increased complication rates. On multivariate analysis, only the grade of spondylolisthesis was significantly associated with the occurrence of complications.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.5.spine09529","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T14:59:52Z","timestamp":1288623592000},"page":"589-593","source":"Crossref","is-referenced-by-count":64,"title":["Morbidity and mortality in the surgical treatment of 10,242 adults with spondylolisthesis"],"prefix":"10.3171","volume":"13","author":[{"given":"Charles A.","family":"Sansur","sequence":"first","affiliation":[{"name":"1Department of Neurosurgery, University of Maryland Medical Center, Baltimore, Maryland;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Davis L.","family":"Reames","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Justin S.","family":"Smith","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D. Kojo","family":"Hamilton","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigurd H.","family":"Berven","sequence":"additional","affiliation":[{"name":"3Department of Orthopedic Surgery, University of California, San Francisco, California;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Paul A.","family":"Broadstone","sequence":"additional","affiliation":[{"name":"4Spine Surgery Associates, PC, Chattanooga, Tennessee;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theodore J.","family":"Choma","sequence":"additional","affiliation":[{"name":"5Orthopaedic Surgery, University of Missouri, Columbia, Missouri;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michael James","family":"Goytan","sequence":"additional","affiliation":[{"name":"6Health Sciences Centre, Winnipeg, Manitoba, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hilali H.","family":"Noordeen","sequence":"additional","affiliation":[{"name":"7The Royal National Orthopedic Hospital, and the Great Ormond Street Children's Hospital, London, United Kingdom;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dennis Raymond","family":"Knapp","sequence":"additional","affiliation":[{"name":"8Arnold Palmer Children's Hospital, Orlando, Florida;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Robert A.","family":"Hart","sequence":"additional","affiliation":[{"name":"9Orthopaedics Department, Oregon Health & Science University, Portland, Oregon;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Reinhard D.","family":"Zeller","sequence":"additional","affiliation":[{"name":"10Division of Orthopedic Surgery, Hospital for Sick Children, Toronto, Ontario, Canada;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William F.","family":"Donaldson","sequence":"additional","affiliation":[{"name":"11University of Pittsburgh Physicians, Orthopedic Surgery, Pittsburgh, Pennsylvania;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David W.","family":"Polly","sequence":"additional","affiliation":[{"name":"12Departments of Orthopaedic Surgery and Neurosurgery, University of Minnesota, Minneapolis;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph H.","family":"Perra","sequence":"additional","affiliation":[{"name":"13Twin Cities Spine Center, Minneapolis, Minnesota; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oheneba","family":"Boachie-Adjei","sequence":"additional","affiliation":[{"name":"14Hospital for Special Surgery, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Christopher I.","family":"Shaffrey","sequence":"additional","affiliation":[{"name":"2Department of Neurosurgery, University of Virginia Health System, Charlottesville, Virginia;"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/00002517-199306060-00001"},{"key":"b2-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000251918.19508.b3"},{"key":"b3-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000197188.76369.13"},{"issue":"6","key":"b4-0130589","doi-asserted-by":"crossref","first-page":"S49","DOI":"10.1097\/01.brs.0000155573.34179.7e","volume":"30","author":"DeWald CJ","year":"2005","journal-title":"Spine"},{"key":"b5-0130589","doi-asserted-by":"crossref","first-page":"130","DOI":"10.5435\/00124635-200803000-00004","volume":"16","author":"DiPaola CP","year":"2008","journal-title":"J Am Acad Orthop Surg"},{"key":"b6-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/BRS.0b013e31814b1bd8"},{"key":"b7-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-199712150-00003"},{"key":"b8-0130589","doi-asserted-by":"publisher","DOI":"10.1016\/j.spinee.2008.08.011"},{"key":"b9-0130589","doi-asserted-by":"crossref","first-page":"802","DOI":"10.2106\/00004623-199173060-00002","volume":"73","author":"Herkowitz HN","year":"1991","journal-title":"J Bone Joint Surg Am"},{"key":"b10-0130589","doi-asserted-by":"publisher","DOI":"10.1007\/s00586-005-1021-4"},{"key":"b11-0130589","doi-asserted-by":"crossref","first-page":"43","DOI":"10.2106\/00004623-198365010-00007","volume":"65","author":"Johnson JR","year":"1983","journal-title":"J Bone Joint Surg Br"},{"key":"b12-0130589","doi-asserted-by":"crossref","first-page":"1250","DOI":"10.1097\/BRS.0b013e3181714a44","volume":"33","author":"Li G","year":"2008","journal-title":"Spine"},{"key":"b13-0130589","doi-asserted-by":"crossref","first-page":"404","DOI":"10.2106\/00004623-197557030-00020","volume":"57","author":"MacEwen GD","year":"1975","journal-title":"J Bone Joint Surg Am"},{"key":"b14-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/00007632-200007010-00016"},{"key":"b15-0130589","doi-asserted-by":"publisher","DOI":"10.1097\/01.brs.0000192678.25586.e5"},{"key":"b16-0130589","doi-asserted-by":"publisher","DOI":"10.1056\/NEJMoa070302"},{"key":"b17-0130589","doi-asserted-by":"publisher","DOI":"10.2106\/JBJS.H.00913"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/13\/5\/article-p589.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"http:\/\/thejns.org\/doi\/pdf\/10.3171\/2010.5.SPINE09529","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2020,5,1]],"date-time":"2020-05-01T22:53:19Z","timestamp":1588373599000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/13\/5\/article-p589.xml"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2010,11]]},"references-count":17,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2010.5.spine09529","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2010,11]]}}}