{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:05:18Z","timestamp":1780131918975,"version":"3.54.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2010,10]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>The objective of this study was to evaluate and analyze morphometric and volumetric changes of the skull due to acromegaly in areas relevant for neurosurgical practice, focusing on the surgical implications.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>On preoperatively acquired CT scans, cephalometric and volumetric measurements were performed on 45 patients with acromegaly (Group A) and 45 control patients (Group B). The authors determined thickness of the cranial vault, inner and outer diameters of the skull, and the diameter of sphenoidal and maxillary sinus, as well as frontal and maxillary sinus volumetry. The morphometric and volumetric CT data of the patients with acromegaly were compared with the data of a control group and correlated with clinical parameters.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>\n                      Cranial vault thickness differed significantly (p &lt; 0.0001) between the 2 groups. A correlation of the vault thickness with preoperative human growth hormone, insulin-like growth factor\u2013I levels, and duration of clinical history in acromegaly could not be established. The outer anterior-posterior skull diameter of Group A (18.47 \u00b1 0.94 cm) differed significantly (p = 0.0146) from Group B (17.98 \u00b1 0.93 cm) and correlated significantly with preoperative human growth hormone (r = 0.3277; p = 0.0299) and insulin-like growth factor-\u2013I serum levels (r = 0.3756; p = 0.0120). Measurements of the anterior-posterior diameter of the sphenoidal sinus differed significantly (p = 0.0074) between patients with acromegaly and controls. Volumetric analysis of the frontal sinus resulted in a statistically significant difference (p = 0.0382) between patients with acromegaly (14.89 \u00b1 10.85 cm\n                      <jats:sup>3<\/jats:sup>\n                      ) and controls (10.06 \u00b1 6.93 cm\n                      <jats:sup>3<\/jats:sup>\n                      ).\n                    <\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Significant craniometric changes and volumetric remodelling of the paranasal sinus occur in acromegaly. The bone alterations are of surgical importance for using the transsphenoidal approach. Detailed preoperative diagnostic examination and planning as well as selection of appropriate instruments are mandatory for safe and successful pituitary adenoma removal in patients with acromegaly.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2010.7.focus10152","type":"journal-article","created":{"date-parts":[[2010,10,1]],"date-time":"2010-10-01T09:59:03Z","timestamp":1285927143000},"page":"E3","source":"Crossref","is-referenced-by-count":30,"title":["Craniometric changes in patients with acromegaly from a surgical perspective"],"prefix":"10.3171","volume":"29","author":[{"given":"Florian H.","family":"Ebner","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Verena","family":"K\u00fcrschner","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Klaus","family":"Dietz","sequence":"additional","affiliation":[{"name":"Medical Biometry, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eva","family":"B\u00fcltmann","sequence":"additional","affiliation":[{"name":"Department of Neuroradiology, Medical School, Hannover, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Thomas","family":"N\u00e4gele","sequence":"additional","affiliation":[{"name":"Neuroradiology, Eberhard-Karls University, Tuebingen; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Juergen","family":"Honegger","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0290003","series-title":"Surg Neurol","doi-asserted-by":"publisher","first-page":"396","DOI":"10.1016\/S0090-3019(00)00179-8","article-title":"\u201cSpontaneous\u201d reduction of tonsillar herniation in acromegaly: a case report","volume":"53","author":"Agostinis","year":"2000"},{"key":"b2-0290003","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"980","DOI":"10.3171\/jns.2006.104.6.980","article-title":"Resolution of Chiari malformation after treatment of acromegaly. 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