{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,22]],"date-time":"2026-10-22T17:30:36Z","timestamp":1792690236197,"version":"4.5.0"},"reference-count":27,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"Special_Supplement","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The goal of this study was to assess the long-term results of Gamma Knife surgery (GKS) in patients harboring an optic nerve sheath meningioma (ONSM).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Thirty patients harboring an ONSM were treated with GKS between 1998 and 2003. Gamma Knife surgery was performed as the sole treatment option in 21 of these patients and resection had been performed previously in 9 patients. The mean volume of the tumor at the time of GKS was 3.6 cm<jats:sup>3<\/jats:sup> (range 1.4\u20139.7 cm<jats:sup>3<\/jats:sup>), and the mean prescription peripheral dose was 13.3 Gy (range 10\u201317 Gy). The mean number of isocenters used to treat these lesions was 8 (range 5\u201314 isocenters).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>At a median follow-up of 56 months, visual acuity improved in 11 patients, remained stable in 13 patients (including 4 patients who were completely blind before GKS), and deteriorated in 6 patients. Follow-up images were available in all patients and showed tumor regression in 20 patients and stable tumor in 8 patients. Persistent imaging evidence of progression was only present in 2 patients. With the exception of reversible conjunctival edema in 4 cases, no other serious acute side effect was observed.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Gamma Knife surgery provides long-term tumor control for ONSM. The results of this study add substantial evidence that GKS may definitely become a standard treatment approach in selected cases of ONSM.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.7.gks10869","type":"journal-article","created":{"date-parts":[[2018,11,16]],"date-time":"2018-11-16T01:09:47Z","timestamp":1542330587000},"page":"28-33","source":"Crossref","is-referenced-by-count":30,"title":["Long-term results of Gamma Knife surgery for optic nerve sheath meningioma"],"prefix":"10.3171","volume":"113","author":[{"given":"Dong","family":"Liu","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Desheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhiyuan","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yipei","family":"Zhang","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yanhe","family":"Li","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xiaomin","family":"Liu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qiang","family":"Jia","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ligao","family":"Zheng","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Guoxiang","family":"Song","sequence":"additional","affiliation":[{"name":"Ophthalmology, Tianjin Medical University Second Hospital, Tianjin, People's Republic of China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-1130028","series-title":"Orbit","first-page":"199","article-title":"Interactive image guidance for surgical localization of orbital apical tumors","volume":"21","author":"Berger","year":"2002"},{"key":"b2-1130028","series-title":"Curr Opin Ophthalmol","first-page":"406","article-title":"Optic nerve sheath meningiomas and advanced treatment options","volume":"15","author":"Carrasco","year":"2004"},{"key":"b3-1130028","series-title":"Acta Neurochir (Wien)","first-page":"27","article-title":"Surgical treatment of meningiomas of the orbit and optic canal: a retrospective study with particular attention to the visual outcome","volume":"126","author":"Cristante","year":"1994"},{"key":"b4-1130028","series-title":"BME & Clin Med","first-page":"22","article-title":"[Gamma knife radiosurgery in intra-orbital tumors.]","volume":"7","author":"Desheng","year":"2003"},{"key":"b5-1130028","series-title":"Surv Ophthalmol","first-page":"167","article-title":"Optic nerve sheath meningiomas","volume":"37","author":"Dutton","year":"1992"},{"issue":"5","key":"b6-1130028","series-title":"Neurosurg Focus","first-page":"E4","article-title":"Optic nerve sheath meningioma: current diagnosis and treatment","volume":"23","author":"Eddleman","year":"2007"},{"key":"b7-1130028","series-title":"Surv Ophthalmol","first-page":"545","article-title":"Radiation therapy for orbital tumors: concepts, current use, and ophthalmic radiation side effects","volume":"54","author":"Finger","year":"2009"},{"key":"b8-1130028","series-title":"Primary Optic Nerve Sheath Meningioma","first-page":"1","article-title":"Overall introduction, problem definition, incidence","author":"Jeremi\u0107","year":"2008"},{"key":"b9-1130028","series-title":"Clin Neurol Neurosurg","first-page":"1003","article-title":"Gamma knife radiosurgery for orbital tumors","volume":"110","author":"Kim","year":"2008"},{"key":"b10-1130028","series-title":"Ophthalmology","first-page":"1214","article-title":"Orbital decompression as an alternative management strategy for patients with benign tumors located at the orbital apex","volume":"113","author":"Kloek","year":"2006"},{"issue":"Suppl","key":"b11-1130028","series-title":"J Neurosurg","first-page":"143","article-title":"Visual changes after gamma knife surgery for optic nerve tumors. Report of three cases","volume":"102","author":"Kwon","year":"2005"},{"key":"b12-1130028","series-title":"J Neurosurg","first-page":"43","article-title":"Dose-response tolerance of the visual pathways and cranial nerves of the cavernous sinus to stereotactic radiosurgery","volume":"88","author":"Leber","year":"1998"},{"key":"b13-1130028","series-title":"Br J Ophthalmol","first-page":"559","article-title":"Long-term response to fractionated radiotherapy of presumed optic nerve sheath meningioma","volume":"94","author":"Lesser","year":"2010"},{"key":"b14-1130028","series-title":"Ophthalmology","first-page":"560","article-title":"Optic nerve sheath meningioma. Definition of intraorbital, intracanalicular, and intracranial components with magnetic resonance imaging","volume":"99","author":"Lindblom","year":"1992"},{"issue":"5","key":"b15-1130028","series-title":"Neurosurg Focus","first-page":"e7","article-title":"Update on treatment modalities for optic nerve sheath meningiomas","volume":"14","author":"Liu","year":"2003"},{"issue":"3 Suppl","key":"b16-1130028","series-title":"Int J Radiat Oncol Biol Phys","first-page":"S28","article-title":"Radiation dose-volume effects of optic nerves and chiasm","volume":"76","author":"Mayo","year":"2010"},{"key":"b17-1130028","series-title":"Br J Ophthalmol","first-page":"1198","article-title":"The evolving management of optic nerve sheath meningiomas","volume":"86","author":"Miller","year":"2002"},{"key":"b18-1130028","series-title":"J Neuroophthalmol","first-page":"200","article-title":"New concepts in the diagnosis and management of optic nerve sheath meningioma","volume":"26","author":"Miller","year":"2006"},{"key":"b19-1130028","series-title":"Int J Radiat Oncol Biol Phys","first-page":"755","article-title":"Radiation optic neuropathy after megavoltage externalbeam irradiation: analysis of time-dose factors","volume":"30","author":"Parsons","year":"1994"},{"key":"b20-1130028","series-title":"Clin Neurol Neurosurg","first-page":"470","article-title":"The role of surgery in meningiomas involving the optic nerve sheath","volume":"108","author":"Roser","year":"2006"},{"key":"b21-1130028","series-title":"Br J Ophthalmol","first-page":"564","article-title":"Primary radiotherapy in progressive optic nerve sheath meningiomas: a long-term follow-up study","volume":"94","author":"Saeed","year":"2010"},{"key":"b22-1130028","series-title":"Ophthalmology","first-page":"2019","article-title":"Optic nerve sheath meningiomas","volume":"110","author":"Saeed","year":"2003"},{"key":"b23-1130028","series-title":"J Neurosurg","first-page":"951","article-title":"Surgical management of meningiomas involving the optic nerve sheath","volume":"101","author":"Schick","year":"2004"},{"key":"b24-1130028","series-title":"Yan Ke Xue Bao","first-page":"172","article-title":"[The diagnosis and treatment of primary orbital meningioma.]","volume":"4","author":"Song","year":"1988"},{"key":"b25-1130028","series-title":"J Neuroophthalmol","first-page":"222","article-title":"Radiation therapy for visual pathway tumors","volume":"28","author":"Stieber","year":"2008"},{"key":"b26-1130028","series-title":"Cancer Contr","first-page":"334","article-title":"Diagnosis and treatment of orbital optic nerve sheath meningioma","volume":"11","author":"Turbin","year":"2004"},{"key":"b27-1130028","series-title":"Ophthalmology","first-page":"890","article-title":"A long-term visual outcome comparison in patients with optic nerve sheath meningioma managed with observation, surgery, radiotherapy, or surgery and radiotherapy","volume":"109","author":"Turbin","year":"2002"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/Special_Supplement\/article-p28.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/Special_Supplement\/article-p28.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/113\/Special_Supplement\/article-p28.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T04:04:11Z","timestamp":1679889851000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/113\/Special_Supplement\/article-p28.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":27,"journal-issue":{"issue":"Special_Supplement"},"URL":"https:\/\/doi.org\/10.3171\/2010.7.gks10869","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}