{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,28]],"date-time":"2026-02-28T20:41:03Z","timestamp":1772311263234,"version":"3.50.1"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,2]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The aim of this study was to report the results of a large clinical series of patients with symptomatic Rathke cleft cysts (RCCs) who underwent resection by a single neurosurgeon using intraoperative alcohol cauterization, and to review any possible differences in recurrence rates in those treated with this chemically ablative technique.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors performed a retrospective database review of 82 patients (age range 10\u201374 years) with symptomatic RCCs who underwent surgery between 1993 and 2009.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Preoperative symptoms of headaches, vision disturbances, and hormone dysfunction were observed in 68%, 35%, and 56% of patients, respectively. All 82 patients underwent treatment by a single surgeon. Surgery consisting of simple cyst drainage followed by cyst wall biopsy without vigorous cyst wall removal was performed. A subset of these patients (62) received intraoperative alcohol instillation. Perioperative complication rates were low: CSF leakage, symptomatic hyponatremia, and permanent diabetes insipidus (DI) in 2%, 5%, and 0% of patients, respectively. Headaches and vision problems improved or resolved in 71% and 83% of patients, respectively. In addition, hyperprolactinemia, hypothyroidism, panhypopituitarism, DI, and adrenal insufficiency improved or resolved in 94%, 90%, 50%, 33%, and 67% of patients, respectively. Recurrence, as defined by enlargement of the cyst as compared with its appearance on baseline 3-month postoperative MR imaging, was noted in 10.7% of the primary surgery group. There was a trend toward increased recurrence rates in the alcohol-treated (12.9%) versus no\u2013alcohol treatment groups (0%), although not statistically significant (p = 0.20).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>This large, single-surgeon\/single-institution series of patients with symptomatic RCCs confirms that significant postoperative improvement in headaches, vision, and pituitary hormone dysfunction can be achieved via a conservative surgical approach, with low complication and recurrence rates. The data also demonstrate a limited role for alcohol cauterization in the treatment of symptomatic RCCs.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.7.jns091793","type":"journal-article","created":{"date-parts":[[2010,8,27]],"date-time":"2010-08-27T13:59:29Z","timestamp":1282917569000},"page":"310-317","source":"Crossref","is-referenced-by-count":48,"title":["Transsphenoidal resection of 82 Rathke cleft cysts: limited value of alcohol cauterization in reducing recurrence rates"],"prefix":"10.3171","volume":"114","author":[{"given":"Kevin O.","family":"Lillehei","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lars","family":"Widdel","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carolina A.","family":"Arias Astete","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Margaret E.","family":"Wierman","sequence":"additional","affiliation":[{"name":"Medicine, and"},{"name":"Denver Veterans Administration Medical Center, Denver, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bette K.","family":"Kleinschmidt-DeMasters","sequence":"additional","affiliation":[{"name":"Pathology, University of Colorado Denver; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Janice M.","family":"Kerr","sequence":"additional","affiliation":[{"name":"Medicine, and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns091793","series-title":"J Neurosurg Sci","first-page":"65","article-title":"Epithelial cysts related to the Rathke's cleft","volume":"18","author":"Agnetti","year":"1974"},{"key":"b2-jns091793","series-title":"J Neurosurg","first-page":"189","article-title":"Surgical outcomes in 118 patients with Rathke cleft cysts","volume":"102","author":"Aho","year":"2005"},{"key":"b3-jns091793","series-title":"Tumors of the Pituitary Gland. Atlas of Tumor Pathology, Series III","author":"Asa","year":"1998"},{"key":"b4-jns091793","series-title":"J Neurosurg","first-page":"577","article-title":"Surgery for Rathke cleft cysts: technical considerations and outcomes","volume":"101","author":"Benveniste","year":"2004"},{"key":"b5-jns091793","series-title":"J Endocrinol Invest","first-page":"943","article-title":"Symptomatic Rathke's cleft cysts: a report of 24 cases","volume":"27","author":"Cohan","year":"2004"},{"key":"b6-jns091793","series-title":"Surg Neurol","first-page":"482","article-title":"Pituitary function after endonasal surgery for nonadenomatous parasellar tumors: Rathke's cleft cysts, craniopharyngiomas, and meningiomas","volume":"70","author":"Dusick","year":"2008"},{"key":"b7-jns091793","series-title":"Endocr J","first-page":"535","article-title":"Pituitary function in patients with Rathke's cleft cyst: significance of surgical management","volume":"41","author":"Eguchi","year":"1994"},{"key":"b8-jns091793","series-title":"J Neurosurg","first-page":"585","article-title":"Symptomatic Rathke's cleft cyst. 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Frontiers of Hormone Research","first-page":"127","article-title":"Rathke's cleft cysts","volume":"34","author":"Kanter","year":"2006"},{"key":"b16-jns091793","series-title":"J Neurosurg","first-page":"33","article-title":"Surgical treatment of symptomatic Rathke cleft cysts: clinical features and results with special attention to recurrence","volume":"100","author":"Kim","year":"2004"},{"key":"b17-jns091793","series-title":"Neurosurgery","first-page":"410","article-title":"Results of transsphenoidal extirpation of craniopharyngiomas and Rathke's cysts","volume":"28","author":"Landolt","year":"1991"},{"key":"b18-jns091793","series-title":"J Neurosurg","first-page":"571","article-title":"Rathke cleft cysts","volume":"101","author":"Laws","year":"2004"},{"key":"b19-jns091793","series-title":"Minim Invasive Neurosurg","first-page":"218","article-title":"Successful low-dose intracavitary irradiation of a Rathke's cleft cyst with colloidal rhenium-186","volume":"44","author":"Moringlane","year":"2001"},{"key":"b20-jns091793","series-title":"J Clin Endocrinol Metab","first-page":"2357","article-title":"Clinical, radiological and pathological features of patients with Rathke's cleft cysts: tumors that may recur","volume":"82","author":"Mukherjee","year":"1997"},{"key":"b21-jns091793","series-title":"Headache","first-page":"1580","article-title":"Headaches associated with Rathke's cleft cyst","volume":"46","author":"Nishioka","year":"2006"},{"key":"b22-jns091793","series-title":"Am J Dis Child","first-page":"1009","article-title":"Empty sella syndrome secondary to intrasellar cyst in adolescence","volume":"130","author":"Raiti","year":"1976"},{"key":"b23-jns091793","series-title":"Neurosurgery","first-page":"173","article-title":"Radiologic characteristics and results of surgical management of Rathke's cysts in 43 patients","volume":"30","author":"Ross","year":"1992"},{"key":"b24-jns091793","series-title":"Neurochirurgia (Stuttg)","first-page":"18","article-title":"Symptomatic Rathke's cleft cysts; clinical and therapeutic data","volume":"31","author":"Roux","year":"1988"},{"key":"b25-jns091793","series-title":"Surg Neurol","first-page":"459","article-title":"Management of Rathke's cleft cysts","volume":"63","author":"Sade","year":"2005"},{"key":"b26-jns091793","series-title":"J Clin Endocrinol Metab","first-page":"3972","article-title":"Cystic lesions of the pituitary: clinicopathological features distinguishing craniopharyngioma, Rathke's cleft cyst, and arachnoid cyst","volume":"84","author":"Shin","year":"1999"},{"key":"b27-jns091793","series-title":"J Neurosurg","first-page":"540","article-title":"Pituitary cyst lined with a single layer of columnar epithelium","volume":"10","author":"Smith","year":"1953"},{"key":"b28-jns091793","series-title":"J Neurosurg","first-page":"535","article-title":"Clinical, radiographic, and pathological features of symptomatic Rathke's cleft cysts","volume":"74","author":"Voelker","year":"1991"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/2\/article-p310.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/2\/article-p310.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/2\/article-p310.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T06:21:01Z","timestamp":1679898061000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/2\/article-p310.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,2]]},"references-count":28,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2010.7.jns091793","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,2]]}}}