{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,26]],"date-time":"2025-10-26T22:49:37Z","timestamp":1761518977696},"reference-count":15,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2010,11]]},"abstract":"<jats:p>The syndrome of inappropriate antidiuretic hormone secretion (SIADH) is occasionally seen after hypothalamic injury or dysfunction, although it typically occurs in association with other endocrine disturbances. It is has never been described as a presenting feature of a suprasellar arachnoid cyst (SAC) in the pediatric population. The authors describe the case of an enlarging SAC resulting in SIADH as the only presenting feature, with an otherwise normal hypothalamic-pituitary axis.<\/jats:p>\n<jats:p>An SAC was diagnosed in utero in this 5-month-old girl who had a normal functioning hypothalamic-pituitary axis on presentation. Because of cyst enlargement and hydrocephalus, the patient was scheduled for surgery; however, preoperative labs revealed SIADH. After stabilizing the serum sodium concentration with fluid restriction and the administration of 3% sodium chloride, the patient underwent endoscopic cyst fenestration. Postoperatively, she had complete resolution of the SIADH.<\/jats:p>\n<jats:p>Syndrome of inappropriate antidiuretic hormone secretion as the presenting symptom of an SAC has not been previously described. In the aforementioned patient, the proposed mechanism for SIADH was enlargement of the suprasellar arachnoid cyst causing compression of the supraoptic and paraventricular nuclei and thus overstimulating the secretion of arginine vasopressin, which resulted in SIADH.<\/jats:p>\n<jats:p>The association of SIADH with an SAC is reportable, as is the resolution of the SIADH via cyst fenestration. The authors suggest that SIADH is an uncommon presenting feature of SACs and that syndrome resolution is possible with cyst decompression.<\/jats:p>","DOI":"10.3171\/2010.8.peds10156","type":"journal-article","created":{"date-parts":[[2010,11,1]],"date-time":"2010-11-01T15:03:55Z","timestamp":1288623835000},"page":"486-488","source":"Crossref","is-referenced-by-count":8,"title":["Suprasellar arachnoid cyst resulting in the syndrome of inappropriate antidiuretic hormone secretion"],"prefix":"10.3171","volume":"6","author":[{"given":"Alexandra D.","family":"Beier","sequence":"first","affiliation":[{"name":"Section of Neurosurgery, Providence Hospital and Medical Center, Southfield, Michigan; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Samuel H.","family":"Cheshier","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aabir","family":"Chakraborty","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Peter","family":"Dirks","sequence":"additional","affiliation":[{"name":"Division of Neurosurgery, The Hospital for Sick Children, University of Toronto, Ontario, Canada"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0060486","series-title":"Eur J Pediatr","doi-asserted-by":"publisher","first-page":"348","DOI":"10.1007\/s004310051285","article-title":"Growth, puberty and hypothalamic-pituitary function in children with suprasellar arachnoid cyst","volume":"159","author":"Adan","year":"2000"},{"issue":"2 Suppl","key":"b2-0060486","series-title":"J Neurosurg","first-page":"107","article-title":"Treatment of suprasellar cysts and patient outcome","volume":"105","author":"Crimmins","year":"2006"},{"key":"b3-0060486","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"1013","DOI":"10.1007\/s00381-008-0615-7","article-title":"Endoscopic treatment of suprasellar arachnoid cysts","volume":"24","author":"Er\u015fahin","year":"2008"},{"key":"b4-0060486","series-title":"Acta Neurol Scand","doi-asserted-by":"publisher","first-page":"382","DOI":"10.1034\/j.1600-0404.2003.00036.x","article-title":"Rathke's cleft cyst presenting with hyponatremia and transient central diabetes insipidus","volume":"107","author":"Hsu","year":"2003"},{"key":"b5-0060486","series-title":"Minim Invasive Neurosurg","doi-asserted-by":"publisher","first-page":"243","DOI":"10.1055\/s-2007-985844","article-title":"Endoscopic treatment of in utero diagnosed suprasellar arachnoid cyst and development of salt wasting","volume":"50","author":"I\u015fik","year":"2007"},{"key":"b6-0060486","series-title":"Endocr J","doi-asserted-by":"publisher","first-page":"393","DOI":"10.1507\/endocrj.47.393","article-title":"Syndrome of inappropriate secretion of antidiuretic hormone (SIADH) and adrenal insufficiency induced by rathke's cleft cyst: a case report","volume":"47","author":"Iwai","year":"2000"},{"key":"b7-0060486","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"554","DOI":"10.1212\/01.WNL.0000078196.83215.4D","article-title":"Idiopathic normal pressure hydrocephalus predominantly with prolonged fever and hyponatremia","volume":"61","author":"Jung","year":"2003"},{"key":"b8-0060486","series-title":"Pediatr Neurosurg","doi-asserted-by":"publisher","first-page":"316","DOI":"10.1159\/000028882","article-title":"The endocrine spectrum of arachnoid cysts in childhood","volume":"31","author":"Mohn","year":"1999"},{"key":"b9-0060486","series-title":"Childs Nerv Syst","doi-asserted-by":"publisher","first-page":"281","DOI":"10.1007\/BF00300797","article-title":"Arachnoid cysts in children: a European co-operative study","volume":"8","author":"Oberbauer","year":"1992"},{"key":"b10-0060486","series-title":"Neurol Med Chir (Tokyo)","doi-asserted-by":"publisher","first-page":"58","DOI":"10.2176\/nmc.47.58","article-title":"Clinicopathological and endocrinological study of Rathke's cleft cyst manifesting as hyponatremia","volume":"47","author":"Ogawa","year":"2007"},{"key":"b11-0060486","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"355","DOI":"10.3171\/jns.1990.73.3.0355","article-title":"Presentation and management of suprasellar arachnoid cysts. 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