{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,24]],"date-time":"2026-02-24T09:37:57Z","timestamp":1771925877824,"version":"3.50.1"},"reference-count":49,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,2]]},"abstract":"\nObject<\/jats:title>\nLocal administration of insulin-like growth factor\u2013I (IGF-I) has been shown to increase the rate of axon regeneration in crush-injured and freeze-injured rat sciatic nerves. Local administration of platelet-rich plasma (PRP) has been also shown to have a measurable effect on facial nerve regeneration after transection in a rat model. The objective of the study was to compare the effects of locally administered IGF-I and PRP on the parameters of the Sciatic Function Index (SFI), sensory function (SF), axon count, and myelin thickness\/axon diameter ratio (G-ratio) in a rat model of crush-injured sciatic nerves.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe right sciatic nerve of Wistar albino rats (24 animals) was crushed using a Yasargil-Phynox aneurysm clip for 45 minutes. All animals were randomly divided into 3 groups: Group 1 (control group) was treated with saline, Group 2 was treated with IGF-I, and Group 3 was treated with PRP. Injections were performed using the tissue expander's injection port with a connecting tube directed at the crush-injured site. Functional recovery was assessed with improvement in the SFI. Recovery of sensory function was using the pinch test. Histopathological examination was performed 3 months after the injury.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThe SFI showed an improved functional recovery in the IGF-I\u2013treated animals (Group 2) compared with the saline-treated animals (Group 1) 30 days after the injury. In IGF-I\u2013treated rats, sensory function returned to the baseline level significantly faster than in saline-treated and PRP-treated rats as shown in values between SF-2 and SF-7. The G-ratios were found to be significantly higher in both experimental groups than in the control group.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThis study suggests that the application of IGF-I to the crush-injured site may expedite the functional recovery of paralyzed muscle by increasing the rate of axon regeneration.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.9.jns091928","type":"journal-article","created":{"date-parts":[[2010,10,29]],"date-time":"2010-10-29T11:48:51Z","timestamp":1288352931000},"page":"522-528","source":"Crossref","is-referenced-by-count":78,"title":["Effects of insulin-like growth factor\u2013I and platelet-rich plasma on sciatic nerve crush injury in a rat model"],"prefix":"10.3171","volume":"114","author":[{"given":"Erhan","family":"Emel","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Selma S\u00f6nmez","family":"Erg\u00fcn","sequence":"additional","affiliation":[{"name":"Plastic and Reconstructive Surgery, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dilcan","family":"Kotan","sequence":"additional","affiliation":[{"name":"Deparment of Neurology, Atat\u00fcrk Medical School, Erzurum, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Esra Ba\u015far","family":"G\u00fcrsoy","sequence":"additional","affiliation":[{"name":"Neurology, Vakif Gureba Hospital;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ye\u015fim","family":"Parman","sequence":"additional","affiliation":[{"name":"Department of Neurology, Istanbul Medical School;"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asli","family":"Zengin","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Institute for Experimental Medicine, Istanbul University, Istanbul; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Asiye","family":"Nurten","sequence":"additional","affiliation":[{"name":"Department of Neuroscience, Institute for Experimental Medicine, Istanbul University, Istanbul; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns091928","series-title":"Brain Res","first-page":"28","article-title":"A single intracerebral microinjection of platelet-derived growth factor (PDGF) accelerates the rate of remyelination in vivo","volume":"918","author":"Allamargot","year":"2001"},{"key":"b2-jns091928","series-title":"Acta Orthop Scand","first-page":"93","article-title":"Platelet concentrate injection improves Achilles tendon repair in rats","volume":"75","author":"Aspenberg","year":"2004"},{"key":"b3-jns091928","series-title":"Plast Reconstr Surg","first-page":"129","article-title":"Functional evaluation of complete sciatic, peroneal, and posterior tibial nerve lesions in the 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