{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,20]],"date-time":"2026-04-20T22:48:20Z","timestamp":1776725300899,"version":"3.51.2"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The outcomes after Gamma Knife surgery (GKS) were retrospectively analyzed in patients with brain metastases from radioresistant primary colorectal cancer to evaluate the efficacy of GKS and the prognostic factors for local tumor control and overall survival.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors reviewed the medical records of 152 patients with 616 tumors. The group included 102 men and 50 women aged 35\u201385 years (mean age 64.4 years), who underwent GKS for metastatic brain tumors from colorectal cancer between April 1992 and September 2008 at Yokohama Rosai Hospital.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The mean prescription dose to the tumor margin was 18.5 Gy (range 8\u201330 Gy). The mean tumor volume at GKS was 2.0 cm<jats:sup>3<\/jats:sup> (range 0.004\u201310.0 cm<jats:sup>3<\/jats:sup>). The primary tumors were located in the colon in 88 patients and the rectum in 64. The median interval between the diagnosis of primary lesions and the diagnosis of brain metastases was 27 months (range 0\u2013180 months). The median neuroradiological follow-up period after GKS was 3 months (mean 6.4 months, range 1\u201393 months). The local tumor growth control rate, based on MR imaging, was 91.2%. The significant factors for unfavorable local tumor growth control, based on multivariate analysis, were larger tumor volume (p = 0.001) and lower margin dose (p = 0.016). The median overall survival time was 6 months. Lower Karnofsky Performance Scale (KPS) score (p = 0.026) and the presence of extracranial metastases (p = 0.004) at first GKS were significantly correlated with poor overall survival period in multivariate analysis. The cause of death was systemic disease in 112 patients and neurological disease in 13 patients. Leptomeningeal carcinomatosis was significantly correlated with a shorter duration of neurological survival in multivariate analysis (p &lt; 0.0001).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Gamma Knife surgery is effective for suppression of local tumor growth in patients with brain metastases from radioresistant colorectal primary cancer. Therefore, clinical and radiological screening of intracranial metastases for patients with lower KPS scores and\/or the presence of extracranial metastases as well as follow-up examinations after GKS for brain metastases should be performed periodically in patients with colorectal cancer, because the neurological prognosis is improved by initial and repeat GKS for newly diagnosed or recurrent tumors leading to a prolonged high-quality survival period.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.9.jns10354","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T13:40:17Z","timestamp":1287150017000},"page":"782-789","source":"Crossref","is-referenced-by-count":46,"title":["Gamma Knife surgery for brain metastases from colorectal cancer"],"prefix":"10.3171","volume":"114","author":[{"given":"Shigeo","family":"Matsunaga","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, Yokohama Rosai Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Takashi","family":"Shuto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yokohama Rosai Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nobutaka","family":"Kawahara","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Graduate School of Medical Sciences, Yokohama City University, Yokohama, Kanagawa, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Suenaga","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yokohama Rosai Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shigeo","family":"Inomori","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Yokohama Rosai Hospital; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hideyo","family":"Fujino","sequence":"additional","affiliation":[{"name":"Department 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