{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,4]],"date-time":"2025-11-04T23:07:13Z","timestamp":1762297633153},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>Placement of covered stents has emerged as a promising therapeutic option for cerebrovascular diseases. However, the medium- and long-term efficacy and safety of covered stents in the treatment of these diseases remain unclear. The purpose of this study was to evaluate the medium-term clinical and angiographic outcomes of covered stent placement for the treatment of intracranial aneurysms.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors' institutional review board approved the study. Thirty-four patients (13 females and 21 males; mean age 41.9 years) with 38 intracranial aneurysms were treated with the Willis covered stent. Clinical and angiographic follow-up were performed at 3 months, at 6\u201312 months, and annually thereafter. The initial procedural and follow-up outcomes were collected and analyzed retrospectively.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Forty-two covered stents were successfully implanted into the target artery in 33 patients with 37 aneurysms, and 1 covered stent navigation failed in 1 patient. A complete aneurysm exclusion was initially achieved in 24 patients with 28 aneurysms, and a minor endoleak occurred in 9 patients with 9 aneurysms. Postoperatively, 2 patients died of complications related to the procedure. Angiographic and clinical follow-up data are available in 30 patients. The angiographic follow-up (17.5 \u00b1 9.4 months [mean \u00b1 SD]) exhibited complete occlusion in 28 patients with 31 aneurysms, and incomplete occlusion in 2 aneurysms, with an asymptomatic in-stent stenosis in 3 patients (10%). The clinical follow-up (26.7 \u00b1 13 months [mean \u00b1 SD]) demonstrated that 16 patients (53.3%) experienced a full recovery, and 14 patients (46.7%) improved. No aneurysm rupture, thromboembolic events, or neurological deficits resulting from closure of a perforating vessel by covered stent placement occurred.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Endovascular reconstruction with the Willis covered stent represents a safe, durable, and curative treatment option for selected intracranial aneurysms, yielding an excellent medium-term patency of the parent artery and excellent clinical outcomes.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.9.jns10373","type":"journal-article","created":{"date-parts":[[2010,10,22]],"date-time":"2010-10-22T14:00:20Z","timestamp":1287756020000},"page":"1014-1020","source":"Crossref","is-referenced-by-count":21,"title":["Reconstructive endovascular treatment of intracranial aneurysms with the Willis covered stent: medium-term clinical and angiographic follow-up"],"prefix":"10.3171","volume":"114","author":[{"given":"Hua-Qiao","family":"Tan","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ming-Hua","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pei-Lei","family":"Zhang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yong-Dong","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jian-Bo","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yue-Qi","family":"Zhu","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Wu","family":"Wang","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns10373","series-title":"Neurosurgery","first-page":"658","article-title":"Treatment of an iatrogenic petrous carotid artery pseudoaneurysm with a Symbiot covered stent: technical case report","volume":"50","author":"Alexander","year":"2002"},{"key":"b2-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"342","article-title":"Angiographic follow-up of traumatic carotid cavernous fistulas treated with endovascular stent graft placement","volume":"28","author":"Archondakis","year":"2007"},{"key":"b3-jns10373","series-title":"J Vasc Interv Radiol","first-page":"1145","article-title":"Endovascular treatment of a giant intracranial aneurysm with a stent-graft","volume":"15","author":"Blasco","year":"2004"},{"key":"b4-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"608","article-title":"Stent-graft placement for wide-neck aneurysm of the vertebrobasilar junction","volume":"25","author":"Burbelko","year":"2004"},{"key":"b5-jns10373","series-title":"Circulation","first-page":"2823","article-title":"Early potent antithrombotic effect with combined aspirin and a loading dose of clopidogrel on experimental arterial thrombogenesis in humans","volume":"101","author":"Cadroy","year":"2000"},{"key":"b6-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"181","article-title":"Carotid blowout syndrome in patients with head-and-neck cancers: reconstructive management by self-expandable stentgrafts","volume":"28","author":"Chang","year":"2007"},{"key":"b7-jns10373","series-title":"Neurosurgery","first-page":"213","article-title":"Intravascular graft stent treatment of a ruptured fusiform dissecting aneurysm of the intracranial vertebral artery: technical case report","volume":"50","author":"Chiaradio","year":"2002"},{"key":"b8-jns10373","series-title":"Neurosurgery","first-page":"631","article-title":"Treatment of extracranial and intracranial aneurysms and arteriovenous fistulae using stent grafts","volume":"55","author":"Felber","year":"2004"},{"key":"b9-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1762","article-title":"Treatment of carotid cavernous fistulas using covered stents: midterm results in seven patients","volume":"28","author":"Gomez","year":"2007"},{"issue":"5 Suppl 2","key":"b10-jns10373","series-title":"Neurosurgery","first-page":"ONS380","article-title":"Stent graft treatment of cerebrovascular wall defects: intermediate-term clinical and angiographic results","volume":"62","author":"Hoit","year":"2008"},{"key":"b11-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1589","article-title":"Bare stent-graft technique: a new method of endoluminal vascular reconstruction for the treatment of giant and fusiform aneurysms","volume":"23","author":"Islak","year":"2002"},{"key":"b12-jns10373","series-title":"Neurosurgery","first-page":"E386","article-title":"Resolution of an infectious pseudoaneurysm in a cervical petrous carotid vein bypass graft after covered stent placement: case report","volume":"58","author":"Kim","year":"2006"},{"key":"b13-jns10373","series-title":"J Neurosurg","first-page":"607","article-title":"Endovascular coil embolization of intracranial aneurysms: important factors related to rates and outcomes of incomplete occlusion","volume":"102","author":"Kole","year":"2005"},{"key":"b14-jns10373","series-title":"Neurosurgery","first-page":"1347","article-title":"Treatment of experimentally induced aneurysms with stents","volume":"56","author":"Krings","year":"2005"},{"key":"b15-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1760","article-title":"Use of covered stent grafts in the extracranial carotid artery: report of three patients with follow-up between 8 and 42 months","volume":"25","author":"Layton","year":"2004"},{"key":"b16-jns10373","series-title":"J Neurosurg","first-page":"431","article-title":"Reconstructive endovascular treatment of ruptured blood blister\u2013like aneurysms of the internal carotid artery. Clinical article","volume":"110","author":"Lee","year":"2009"},{"key":"b17-jns10373","series-title":"N Engl J Med","first-page":"1665","article-title":"A clinical trial comparing three antithrombotic-drug regimens after coronary-artery stenting","volume":"339","author":"Leon","year":"1998"},{"key":"b18-jns10373","series-title":"Neuroradiology","first-page":"819","article-title":"Endovascular treatment of giant or very large intracranial aneurysms with different modalities: an analysis of 20 cases","volume":"49","author":"Li","year":"2007"},{"key":"b19-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1579","article-title":"A new covered stent designed for intracranial vasculature: application in the management of pseudoaneurysms of the cranial internal carotid artery","volume":"28","author":"Li","year":"2007"},{"key":"b20-jns10373","series-title":"Radiology","first-page":"470","article-title":"Treatment of distal internal carotid artery aneurysm with the Willis covered stent: a prospective pilot study","volume":"253","author":"Li","year":"2009"},{"key":"b21-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1395","article-title":"The feasibility and efficacy of treatment with a Willis covered stent in recurrent intracranial aneurysms after coiling","volume":"29","author":"Li","year":"2008"},{"key":"b22-jns10373","series-title":"J Neurosurg","first-page":"969","article-title":"Traumatic carotid artery-cavernous sinus fistula treated with a covered stent. Report of two cases","volume":"104","author":"Madan","year":"2006"},{"key":"b23-jns10373","series-title":"J Endovasc Ther","first-page":"742","article-title":"Covered stents to treat partial recanalization of onyx-occluded giant intracavernous carotid aneurysm","volume":"11","author":"Magoufis","year":"2004"},{"key":"b24-jns10373","series-title":"J Vasc Surg","first-page":"1020","article-title":"Endoluminal repair of carotid artery pseudoaneurysms: a word of caution","volume":"40","author":"McCready","year":"2004"},{"key":"b25-jns10373","series-title":"J Stroke Cerebrovasc Dis","first-page":"304","article-title":"International Subarachnoid Aneurysm Trial (ISAT) of neurosurgical clipping versus endovascular coiling in 2143 patients with ruptured intracranial aneurysms: a randomized trial","volume":"11","author":"Molyneux","year":"2002"},{"key":"b26-jns10373","series-title":"Stroke","first-page":"711","article-title":"Methods, patient characteristics, and progress","volume":"22","author":"North American Symptomatic Carotid Endarterectomy Trial","year":"1991"},{"key":"b27-jns10373","series-title":"J Neurosurg","first-page":"965","article-title":"Treatment of a middle cerebral artery giant aneurysm using a covered stent. Case report","volume":"104","author":"Pero","year":"2006"},{"key":"b28-jns10373","series-title":"Cardiovasc Intervent Radiol","first-page":"854","article-title":"Exclusion of atherosclerotic plaque from the circulation using stent-grafts: alternative to carotid stenting with a protection device?","volume":"30","author":"Peynircioglu","year":"2007"},{"key":"b29-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1594","article-title":"Placement of covered stents for carotid blowout in patients with head and neck cancer: follow-up results after rescue treatments","volume":"28","author":"Pyun","year":"2007"},{"key":"b30-jns10373","series-title":"Stroke","first-page":"1398","article-title":"Long-term angiographic recurrences after selective endovascular treatment of aneurysms with detachable coils","volume":"34","author":"Raymond","year":"2003"},{"key":"b31-jns10373","series-title":"J Neurosurg","first-page":"412","article-title":"Treatment of traumatic aneurysms and arteriovenous fistulas of the skull base by using endovascular stents","volume":"95","author":"Redekop","year":"2001"},{"key":"b32-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1742","article-title":"Treatment of internal carotid artery aneurysms with a covered stent: experience in 24 patients with mid-term followup results","volume":"25","author":"Saatci","year":"2004"},{"key":"b33-jns10373","series-title":"Circulation","first-page":"921","article-title":"Lack of adverse clopidogrel-atorvastatin clinical interaction from secondary analysis of a randomized, placebo-controlled clopidogrel trial","volume":"108","author":"Saw","year":"2003"},{"key":"b34-jns10373","series-title":"J Endovasc Ther","first-page":"312","article-title":"Covered versus bare self-expanding stents for endovascular treatment of carotid artery stenosis: a stopped randomized trial","volume":"13","author":"Schillinger","year":"2006"},{"key":"b35-jns10373","series-title":"Circulation","first-page":"37","article-title":"Randomized evaluation of polytetrafluoroethylene-covered stent in saphenous vein grafts: the Randomized Evaluation of polytetrafluoroethylene COVERed stent in Saphenous vein grafts (RECOVERS) Trial","volume":"108","author":"Stankovic","year":"2003"},{"key":"b36-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"1342","article-title":"Placement of covered stents for the treatment of direct carotid cavernous fistulas","volume":"30","author":"Wang","year":"2009"},{"key":"b37-jns10373","series-title":"Neurosurgery","first-page":"E1176","article-title":"Endovascular treatment of giant intracranial aneurysms with Willis covered stents: technical case report","volume":"62","author":"Wang","year":"2008"},{"key":"b38-jns10373","series-title":"AJNR Am J Neuroradiol","first-page":"983","article-title":"Endovascular treatment of carotid and vertebral pseudoaneurysms with covered stents","volume":"29","author":"Yi","year":"2008"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/4\/article-p1014.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/4\/article-p1014.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/4\/article-p1014.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T05:31:54Z","timestamp":1679895114000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/4\/article-p1014.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,4]]},"references-count":38,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2010.9.jns10373","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,4]]}}}