{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,11,10]],"date-time":"2026-11-10T15:21:58Z","timestamp":1794324118523,"version":"4.9.0"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,3]]},"abstract":"\n Object<\/jats:title>\n The authors report their experience of using Gamma Knife surgery (GKS) in patients with subependymal giant cell astrocytoma (SEGA).<\/jats:p>\n <\/jats:sec>\n \n Methods<\/jats:title>\n \n Over a 20-year period, the authors identified 6 patients with SEGAs who were eligible for GKS. The median patient age was 16.5 years (range 7\u201355 years). In 4 patients, GKS was used as a primary management therapy. One patient underwent radiosurgery for recurrent tumors after prior resection, and in 1 patient GKS was used as an adjunct after subtotal resection. The median tumor volume at GKS was 2.75 cm\n 3<\/jats:sup>\n (range 0.7\u20135.9 cm\n 3<\/jats:sup>\n ). A median radiation dose of 14 Gy (range 11\u201320 Gy) was delivered to the tumor margin.\n <\/jats:p>\n <\/jats:sec>\n \n Results<\/jats:title>\n \n The median follow-up duration was 73 months (range 42\u201390 months). Overall local tumor control was achieved in 4 tumors (67%) with progression-free periods of 24, 42, 57, and 66 months. Three tumors regressed and one remained unchanged. In 2 patients the tumors progressed, and in 1 of these patients the lesion was managed by repeated GKS with subsequent tumor regression. The other relatively large tumor (5.9 cm\n 3<\/jats:sup>\n ) was excised 9 months after GKS. The progression-free period for all GKS-managed tumors varied from 9 to 66 months. There were no cases of hydrocephalus or GKS-related morbidity.\n <\/jats:p>\n <\/jats:sec>\n \n Conclusions<\/jats:title>\n Gamma Knife surgery may be an additional minimally invasive management option for SEGA in a patient who harbors a small but progressively enlarging tumor when complete resection is not safely achievable. It may also benefit patients with a residual or recurrent tumor that has progressed after surgery.<\/jats:p>\n <\/jats:sec>","DOI":"10.3171\/2010.9.jns10816","type":"journal-article","created":{"date-parts":[[2010,10,15]],"date-time":"2010-10-15T09:40:17Z","timestamp":1287135617000},"page":"808-813","source":"Crossref","is-referenced-by-count":40,"title":["Gamma Knife surgery for subependymal giant cell astrocytomas"],"prefix":"10.3171","volume":"114","author":[{"given":"Kyung-Jae","family":"Park","sequence":"first","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Department of Neurological Surgery, College of Medicine, Korea University, Seoul, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hideyuki","family":"Kano","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Douglas","family":"Kondziolka","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ajay","family":"Niranjan","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John C.","family":"Flickinger","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"},{"name":"Radiation Oncology, University of Pittsburgh, Center for Image-Guided Neurosurgery, Pittsburgh, Pennsylvania; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"L. Dade","family":"Lunsford","sequence":"additional","affiliation":[{"name":"Departments of Neurological Surgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns10816","series-title":"Med J Aust","first-page":"811","article-title":"Tuberose sclerosis with malignant astrocytoma","volume":"1","author":"Brown","year":"1975"},{"key":"b2-jns10816","series-title":"Childs Nerv Syst","first-page":"232","article-title":"Subependymal giant cell astrocytoma in children with tuberous sclerosis","volume":"19","author":"Cuccia","year":"2003"},{"key":"b3-jns10816","series-title":"Neurosurgery","first-page":"83","article-title":"Subependymal giant-cell astrocytomas in pediatric tuberous sclerosis disease: when should we operate?","volume":"60","author":"de Ribaupierre","year":"2007"},{"key":"b4-jns10816","series-title":"Pediatr Neurosurg","first-page":"115","article-title":"On the treatment of subependymal giant cell astrocytomas and associated hydrocephalus in tuberous sclerosis","volume":"23","author":"Di Rocco","year":"1995"},{"key":"b5-jns10816","series-title":"Childs Nerv Syst","first-page":"45","article-title":"Intraventricular tumors in tuberous sclerosis","volume":"1","author":"Fr\u00e8rebeau","year":"1985"},{"key":"b6-jns10816","series-title":"Neurology","first-page":"1457","article-title":"Subependymal giant cell tumors in tuberous sclerosis complex","volume":"63","author":"Goh","year":"2004"},{"issue":"5","key":"b7-jns10816","series-title":"Neurosurg Focus","first-page":"e15","article-title":"The role of stereotactic radiosurgery for low-grade astrocytomas","volume":"14","author":"Hadjipanayis","year":"2003"},{"key":"b8-jns10816","series-title":"J Neurosurg","first-page":"106","article-title":"Recurrent subependymal giant-cell astrocytoma in the absence of tuberous sclerosis. Case report","volume":"50","author":"Halmagyi","year":"1979"},{"key":"b9-jns10816","series-title":"Stereotact Funct Neurosurg","first-page":"161","article-title":"Gamma knife stereotactic radiosurgery for lowgrade astrocytomas","volume":"87","author":"Henderson","year":"2009"},{"key":"b10-jns10816","series-title":"Neurosurg Rev","first-page":"139","article-title":"Tuberous sclerosis\u2014neurosurgical indications in intraventricular tumors","volume":"3","author":"Holanda","year":"1980"},{"key":"b11-jns10816","series-title":"Childs Nerv Syst","article-title":"The diagnosis and treatment of subependymal giant cell astrocytoma combined with tuberous sclerosis","author":"Jiang","year":"2010"},{"key":"b12-jns10816","series-title":"J Neurooncol","first-page":"211","article-title":"Stereotactic radiosurgery for pilocytic astrocytomas part 1: outcomes in adult patients","volume":"95","author":"Kano","year":"2009"},{"key":"b13-jns10816","series-title":"J Neurooncol","first-page":"219","article-title":"Stereotactic radiosurgery for pilocytic astrocytomas part 2: outcomes in pediatric patients","volume":"95","author":"Kano","year":"2009"},{"key":"b14-jns10816","series-title":"Eur J Radiol","first-page":"55","article-title":"Solitary subependymal giant cell astrocytoma: case report","volume":"33","author":"Kashiwagi","year":"2000"},{"issue":"Suppl 3","key":"b15-jns10816","series-title":"J Neurosurg","first-page":"42","article-title":"Gamma knife radiosurgery for low-grade astrocytomas: results of long-term follow up","volume":"93","author":"Kida","year":"2000"},{"key":"b16-jns10816","series-title":"J Neurooncol","first-page":"217","article-title":"Biological behavior and tumorigenesis of subependymal giant cell astrocytomas","volume":"52","author":"Kim","year":"2001"},{"key":"b17-jns10816","series-title":"Neurosurg Rev","first-page":"274","article-title":"Subependymal giant cell astrocytoma: a report of five cases","volume":"27","author":"Kumar","year":"2004"},{"key":"b18-jns10816","series-title":"WHO Classification of Tumours of the Central Nervous System","first-page":"218","article-title":"Tuberous sclerosis complex and subependymal giant cell astrocytoma","volume":"1","author":"Lopes","year":"2007"},{"key":"b19-jns10816","series-title":"Neurol Med Chir (Tokyo)","first-page":"287","article-title":"Glioblastoma following radiotherapy in a patient with tuberous sclerosis","volume":"38","author":"Matsumura","year":"1998"},{"key":"b20-jns10816","series-title":"J Clin Neurosci","first-page":"31","article-title":"Subependymal giant cell astrocytoma: clinical and neuroimaging features of four cases","volume":"8","author":"Nishio","year":"2001"},{"key":"b21-jns10816","series-title":"Surg Neurol","first-page":"488","article-title":"Volume changes following gamma knife radiosurgery of intracranial tumors","volume":"48","author":"Park","year":"1997"},{"key":"b22-jns10816","series-title":"Am J Forensic Med Pathol","first-page":"30","article-title":"Sudden death in epilepsy due to an isolated subependymal giant cell astrocytoma of the septum pellucidum","volume":"16","author":"Prahlow","year":"1995"},{"key":"b23-jns10816","series-title":"Childs Nerv Syst","first-page":"335","article-title":"Surgical treatment of intraventricular tumors associated with tuberous sclerosis","volume":"11","author":"Roszkowski","year":"1995"},{"key":"b24-jns10816","series-title":"Pediatr Neurosurg","first-page":"233","article-title":"Subependymal giant cell astrocytomas in children","volume":"20","author":"Sinson","year":"1994"},{"key":"b25-jns10816","series-title":"Neuropathology","first-page":"181","article-title":"Solitary subependymal giant cell astrocytoma incidentally found at autopsy in an elderly woman without tuberous sclerosis complex","volume":"29","author":"Takei","year":"2009"},{"key":"b26-jns10816","series-title":"J Child Neurol","first-page":"173","article-title":"Early diagnosis of subependymal giant cell astrocytoma in patients with tuberous sclerosis","volume":"13","author":"Torres","year":"1998"},{"key":"b27-jns10816","series-title":"Surg Neurol","first-page":"99","article-title":"Massive hemorrhage in tumor of tuberous sclerosis","volume":"8","author":"Waga","year":"1977"},{"issue":"Suppl","key":"b28-jns10816","series-title":"J Neurosurg","first-page":"127","article-title":"Gamma Knife surgery for low-grade astrocytomas: evaluation of long-term outcome based on a 10-year experience","volume":"105","author":"Wang","year":"2006"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/3\/article-p808.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/3\/article-p808.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/114\/3\/article-p808.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T01:58:12Z","timestamp":1679882292000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/114\/3\/article-p808.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,3]]},"references-count":28,"journal-issue":{"issue":"3"},"URL":"https:\/\/doi.org\/10.3171\/2010.9.jns10816","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,3]]}}}