{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,3,5]],"date-time":"2026-03-05T05:51:26Z","timestamp":1772689886878,"version":"3.50.1"},"reference-count":17,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2010,12]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The purpose of this study was to review 14 rare cases of cerebral paragonimiasis that first manifested as intracranial hemorrhage (ICH), and to investigate the characteristics of clinical manifestation, diagnosis, and treatment of the disease.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The authors have encountered 14 cases of cerebral paragonimiasis in patients between the ages of 6 and 16 years (mean age 11.5 years) who presented with sudden headache, nausea, and vomiting. Three of them were affected with varying degrees of limb hemiplegia, and in 1 this was combined with high fever; the blood eosinophil count and enzyme-linked immunosorbent assay showed positive results too. The ICHs were observed with cranial CT and MR imaging, and lung lesions were also detected in 5 cases on chest CT scans. Ten of the diagnosed cases were treated with oral praziquantel. Three of these patients were given carbamazepine from the beginning of parasiticidal treatment to prevent seizures; 4 of the remaining 7 patients experienced epileptic seizures during the treatment process. Four patients needed surgery to remove the lesions, and these individuals received praziquantel treatment right after the surgery.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Pathological examinations demonstrated eosinophilic granuloma in these patients. There was no disease recurrence or epilepsy in 11\u201340 months of follow-up; however, mild hemiplegia could still be observed in 2 cases after 12 months and 17 months of follow-up.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The possibility of cerebral paragonimiasis should be considered when ICH is detected in young patients who are either from an endemic area or have recently visited such an area; the relatively small amount of hemorrhage in cerebral paragonimiasis is often represented as small lesions surrounded by disproportionately larger edema on the imaging study. Preventive antiepileptic drugs should be used along with the administration of parasiticide.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.9.peds1099","type":"journal-article","created":{"date-parts":[[2010,12,1]],"date-time":"2010-12-01T15:00:47Z","timestamp":1291215647000},"page":"572-578","source":"Crossref","is-referenced-by-count":15,"title":["Cerebral paragonimiasis that manifested as intracranial hemorrhage"],"prefix":"10.3171","volume":"6","author":[{"given":"Jingyu","family":"Chen","sequence":"first","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhi","family":"Chen","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Fei","family":"Li","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jiangkai","family":"Lin","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hui","family":"Meng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hua","family":"Feng","sequence":"additional","affiliation":[],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0060572","series-title":"Adv Parasitol","doi-asserted-by":"publisher","first-page":"113","DOI":"10.1016\/S0065-308X(08)60149-9","article-title":"Paragonimiasis and the genus Paragonimus","volume":"42","author":"Blair","year":"1999"},{"key":"b2-0060572","series-title":"Am J Trop Med Hyg","doi-asserted-by":"publisher","first-page":"522","DOI":"10.4269\/ajtmh.1982.31.522","article-title":"Cerebral hemorrhagic lesions produced by Paragonimus mexicanus. Report of three cases in Costa Rica","volume":"31","author":"Brenes Madrigal","year":"1982"},{"key":"b3-0060572","series-title":"AJR Am J Roentgenol","doi-asserted-by":"publisher","first-page":"141","DOI":"10.2214\/ajr.162.1.8273653","article-title":"Cerebral paragonimiasis in early active stage: CT and MR features","volume":"162","author":"Cha","year":"1994"},{"key":"b4-0060572","series-title":"Korean J Radiol Soc","doi-asserted-by":"publisher","first-page":"345","DOI":"10.3348\/jkrs.1993.29.3.345","article-title":"An imaging diagnosis of cerebral paragonimiasis: CT and MR findings and correlation with ELISA antibody test","volume":"29","author":"Chang","year":"1993"},{"key":"b5-0060572","series-title":"Pediatr Neurol","doi-asserted-by":"publisher","first-page":"133","DOI":"10.1016\/j.pediatrneurol.2008.04.004","article-title":"Acute cerebral paragonimiasis presenting as hemorrhagic stroke in a child","volume":"39","author":"Chen","year":"2008"},{"key":"b6-0060572","series-title":"Clin Neurol Neurosurg","doi-asserted-by":"publisher","first-page":"501","DOI":"10.1016\/j.clineuro.2007.04.001","article-title":"Seizures and epilepsy in patients with a spontaneous intracerebral haematoma","volume":"109","author":"De Reuck","year":"2007"},{"key":"b7-0060572","series-title":"Rinsho Shinkeigaku","first-page":"808","article-title":"[A case of cerebral paragonimiasis with intracerebral hemorrhage as initial finding.]","volume":"25","author":"Hara","year":"1985"},{"key":"b8-0060572","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"515","DOI":"10.3171\/jns.1971.34.4.0515","article-title":"Cerebral paragonimiasis","volume":"34","author":"Higashi","year":"1971"},{"key":"b9-0060572","series-title":"Semin Roentgenol","doi-asserted-by":"publisher","first-page":"301","DOI":"10.1016\/S0037-198X(97)80024-7","article-title":"Current diagnostic imaging of pulmonary and cerebral paragonimiasis, with pathological correlation","volume":"32","author":"Im","year":"1997"},{"key":"b10-0060572","series-title":"Pediatr Neurol","doi-asserted-by":"publisher","first-page":"73","DOI":"10.1016\/j.pediatrneurol.2006.09.017","article-title":"Hemorrhagic stroke in children","volume":"36","author":"Jordan","year":"2007"},{"issue":"5 Suppl","key":"b11-0060572","series-title":"AJNR Am J Neuroradiol","first-page":"S21","article-title":"MR imaging of chronic cerebral paragonimiasis","volume":"10","author":"Kadota","year":"1989"},{"key":"b12-0060572","series-title":"Semin Respir Infect","first-page":"149","article-title":"Pulmonary paragonimiasis","volume":"12","author":"Kagawa","year":"1997"},{"key":"b13-0060572","series-title":"Semin Neurol","doi-asserted-by":"publisher","first-page":"201","DOI":"10.1055\/s-2008-1041126","article-title":"Cerebral paragonimiasis","volume":"13","author":"Kusner","year":"1993"},{"key":"b14-0060572","series-title":"Trends Parasitol","doi-asserted-by":"publisher","first-page":"318","DOI":"10.1016\/j.pt.2008.03.014","article-title":"Paragonimiasis: an important food-borne zoonosis in China","volume":"24","author":"Liu","year":"2008"},{"key":"b15-0060572","series-title":"Intern Med","doi-asserted-by":"publisher","first-page":"388","DOI":"10.2169\/internalmedicine.43.388","article-title":"Paragonimiasis cases recently found among immigrants in Japan","volume":"43","author":"Obara","year":"2004"},{"key":"b16-0060572","series-title":"J Neurol Sci","doi-asserted-by":"publisher","first-page":"27","DOI":"10.1016\/0022-510X(69)90039-2","article-title":"Cerebral paragonimiasis","volume":"8","author":"Oh","year":"1969"},{"key":"b17-0060572","series-title":"J Magn Reson Imaging","doi-asserted-by":"publisher","first-page":"569","DOI":"10.1002\/jmri.20546","article-title":"MRI features of pediatric cerebral paragonimiasis in the active stage","volume":"23","author":"Zhang","year":"2006"}],"container-title":["Journal of Neurosurgery: Pediatrics"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/6\/6\/article-p572.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/6\/6\/article-p572.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-pediatr\/6\/6\/article-p572.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T12:27:52Z","timestamp":1681561672000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-pediatr\/6\/6\/article-p572.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2010,12]]},"references-count":17,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2010.9.peds1099","relation":{},"ISSN":["1933-0707","1933-0715"],"issn-type":[{"value":"1933-0707","type":"print"},{"value":"1933-0715","type":"electronic"}],"subject":[],"published":{"date-parts":[[2010,12]]}}}