{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,21]],"date-time":"2026-05-21T03:18:53Z","timestamp":1779333533952,"version":"3.51.4"},"reference-count":28,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["SPI"],"published-print":{"date-parts":[[2011,1]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The goal in this study was to retrospectively investigate the clinical efficacy of surgical treatment for cervical dystrophic kyphotic deformity due to neurofibromatosis Type 1.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>Between January 1998 and July 2008, 8 patients with cervical dystrophic kyphotic deformity due to neurofibromatosis Type 1 (mean Cobb angle of 58.5\u00b0) were surgically treated in the authors' department. The mean age at surgery was 19 years (range 12\u201338 years). Among these patients, 1 with a Cobb angle of 52\u00b0 and good flexibility underwent single anterior correction, whereas the other 7 patients with severe deformity and poor flexibility received combined anterior and posterior cervical osteotomy. Motor-evoked potential studies were used intraoperatively for spinal cord monitoring. Radiographic assessment and Japanese Orthopaedic Association scoring were used to evaluate the clinical outcome.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>No severe neurological complications were noted. Two patients complained of persistent neck and shoulder pain after combined anterior and posterior correction, which alleviated after conservative treatment half a year later. All patients were followed up for a mean of 21.1 months (range 6\u201336 months). All patients had a solid bone fusion at the latest follow-up, with Japanese Orthopaedic Association scoring improving from 11.5 preoperatively to 14.1 postoperatively (p &lt; 0.01) at the final follow-up. The kyphotic deformities improved significantly, with average Cobb angles of 2.5\u00b0 postoperatively and 4.1\u00b0 at final follow-up.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>The deformity of neurofibromatosis with cervical kyphosis is severe, and surgery carries a high risk of failure. Although premature fusion may be performed, the deformity may still progress, and this situation may lead to failure of surgery. The successful management of this disease requires early recognition and a more aggressive and reliable intervention to prevent disastrous worsening of the deformity. Meticulous preoperative evaluation, appropriate surgical strategy, and skilled technique were essential for successful surgical treatment and good clinical results.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2010.9.spine091015","type":"journal-article","created":{"date-parts":[[2010,12,8]],"date-time":"2010-12-08T20:26:54Z","timestamp":1291840014000},"page":"93-98","source":"Crossref","is-referenced-by-count":33,"title":["Surgical treatment of severe cervical dystrophic kyphosis due to neurofibromatosis Type 1: a review of 8 cases"],"prefix":"10.3171","volume":"14","author":[{"given":"Junming","family":"Ma","sequence":"first","affiliation":[{"name":"Department of Orthopedics, LongHua Hospital, Shanghai University of Traditional Chinese Medicine; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Zhipeng","family":"Wu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, ChangZheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xinghai","family":"Yang","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, ChangZheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianru","family":"Xiao","sequence":"additional","affiliation":[{"name":"Department of Orthopedics, ChangZheng Hospital, The Second Military Medical University, Shanghai, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-spine091015","series-title":"Clin Orthop Relat Res","first-page":"53","article-title":"Scoliosis surgery in neurofibromatosis","volume":"245","author":"Betz","year":"1989"},{"key":"b2-spine091015","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"695","DOI":"10.2106\/00004623-197658050-00021","article-title":"Neurofibromatous scoliosis. Natural history and results of treatment in thirty-seven cases","volume":"58","author":"Chaglassian","year":"1976"},{"key":"b3-spine091015","series-title":"Robbins Pathologic Basis of Disease","first-page":"121","article-title":"Genetic disorders","author":"Cotran","year":"1989"},{"key":"b4-spine091015","series-title":"J Bone Joint Surg Br","first-page":"575","article-title":"Neurofibromatosis of the cervical spine. A report of eight cases","volume":"74","author":"Craig","year":"1992"},{"key":"b5-spine091015","series-title":"Clin Orthop Relat Res","first-page":"29","article-title":"Pitfalls of spinal deformities associated with neurofibromatosis in children","volume":"245","author":"Crawford","year":"1989"},{"key":"b6-spine091015","series-title":"J Am Acad Orthop Surg","doi-asserted-by":"publisher","first-page":"217","DOI":"10.5435\/00124635-199907000-00002","article-title":"Neurofibromatosis in children: the role of the orthopaedist","volume":"7","author":"Crawford","year":"1999"},{"key":"b7-spine091015","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"692","DOI":"10.2106\/00004623-199405000-00010","article-title":"Pathophysiology of spinal deformities in neurofibromatosis. An analysis of seventy-one patients who had curves associated with dystrophic changes","volume":"76","author":"Funasaki","year":"1994"},{"key":"b8-spine091015","series-title":"J Bone Joint Surg Br","first-page":"495","article-title":"Dystrophic spinal deformities in neurofibromatosis. Treatment by anterior and posterior fusion","volume":"66","author":"Hsu","year":"1984"},{"key":"b9-spine091015","series-title":"Spine","doi-asserted-by":"publisher","first-page":"2770","DOI":"10.1097\/00007632-199712010-00014","article-title":"Spine update. The management of scoliosis in neurofibromatosis","volume":"22","author":"Kim","year":"1997"},{"key":"b10-spine091015","series-title":"Spine","doi-asserted-by":"publisher","first-page":"2332","DOI":"10.1097\/00007632-199311000-00034","article-title":"One-stage anterior and posterior correction of severe kyphosis of the cervical spine in neurofibromatosis. A case report","volume":"18","author":"Kokubun","year":"1993"},{"key":"b11-spine091015","series-title":"Spine","doi-asserted-by":"publisher","first-page":"331","DOI":"10.1097\/00007632-198007000-00007","article-title":"Neurologic deficits secondary to spinal deformity. A review of the literature and report of 43 cases","volume":"5","author":"Lonstein","year":"1980"},{"key":"b12-spine091015","series-title":"J Bone Joint Surg Br","doi-asserted-by":"publisher","first-page":"197","DOI":"10.1302\/0301-620X.79B2.0790197","article-title":"Osteotomy of the cervical spine in ankylosing spondylitis","volume":"79","author":"McMaster","year":"1997"},{"key":"b13-spine091015","series-title":"Neurofibromatosis","first-page":"124","article-title":"Neurofibromatosis: history, nomenclature, and natural history","volume":"1","author":"Mulvihill","year":"1988"},{"key":"b14-spine091015","series-title":"Clin Orthop Relat Res","doi-asserted-by":"publisher","first-page":"149","DOI":"10.1097\/00003086-199804000-00018","article-title":"Correction of a dystrophic cervicothoracic spine deformity in Recklinghausen's disease","volume":"349","author":"Nijland","year":"1998"},{"key":"b15-spine091015","series-title":"Spine","doi-asserted-by":"publisher","first-page":"2247","DOI":"10.1097\/00007632-199911010-00013","article-title":"Surgical correction of dystrophic spinal curves in neurofibromatosis. A review of 56 patients","volume":"24","author":"Parisini","year":"1999"},{"key":"b16-spine091015","series-title":"Neurofibromatosis: Phenotype, Natural History and Pathogenesis","first-page":"163","author":"Riccardi","year":"1986"},{"key":"b17-spine091015","series-title":"Ital J Orthop Traumatol","first-page":"13","article-title":"Surgical treatment of vertebral deformities in neurofibromatosis","volume":"9","author":"Savini","year":"1983"},{"key":"b18-spine091015","series-title":"Spine J","doi-asserted-by":"publisher","first-page":"461","DOI":"10.1016\/j.spinee.2004.09.015","article-title":"Neurofibromatosis type I with severe dystrophic kyphoscoliosis and its operative management via a simultaneous anterior-posterior approach: a case report and review of the literature","volume":"5","author":"Singh","year":"2005"},{"key":"b19-spine091015","series-title":"J Pediatr Orthop","doi-asserted-by":"publisher","first-page":"522","DOI":"10.1097\/01241398-199010040-00019","article-title":"Dystrophic spinal deformity in neurofibromatosis","volume":"10","author":"Sirois","year":"1990"},{"issue":"1 Supp1 1","key":"b20-spine091015","series-title":"Neurosurgery","first-page":"S90","article-title":"Cervical deformity correction","volume":"60","author":"Steinmetz","year":"2007"},{"issue":"1 Suppl","key":"b21-spine091015","series-title":"Neurosurgery","first-page":"191","article-title":"Techniques for the ventral correction of postsurgical cervical kyphotic deformity","volume":"56","author":"Stewart","year":"2005"},{"key":"b22-spine091015","series-title":"Eur Spine J","doi-asserted-by":"publisher","first-page":"427","DOI":"10.1007\/s00586-004-0829-7","article-title":"Spinal deformity in neurofibromatosis type-1: diagnosis and treatment","volume":"14","author":"Tsirikos","year":"2005"},{"key":"b23-spine091015","series-title":"Rev Chir Orthop Reparatrice Appar Mot","first-page":"737","article-title":"[Neurofibromatosis of the lower cervical spine: an operative case report.]","volume":"86","author":"Vadier","year":"2000"},{"key":"b24-spine091015","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"960","DOI":"10.1227\/00006123-199411000-00025","article-title":"Severe cervical kyphotic deformities in patients with plexiform neurofibromas: case report","volume":"35","author":"Ward","year":"1994"},{"key":"b25-spine091015","series-title":"Spine","doi-asserted-by":"publisher","first-page":"1264","DOI":"10.1097\/00007632-199405310-00013","article-title":"Deterioration of operative correction in dystrophic spinal neurofibromatosis","volume":"19","author":"Wilde","year":"1994"},{"key":"b26-spine091015","series-title":"J Bone Joint Surg Am","doi-asserted-by":"publisher","first-page":"1102","DOI":"10.2106\/00004623-198466070-00019","article-title":"Thoracic lordoscoliosis in neurofibromatosis: treatment by a Harrington rod with sublaminar wiring. Report of two cases","volume":"66","author":"Winter","year":"1984"},{"key":"b27-spine091015","series-title":"J Spinal Disord","first-page":"39","article-title":"Neurofibromatosis hyperkyphosis: a review of 33 patients with kyphosis of 80 degrees or greater","volume":"1","author":"Winter","year":"1988"},{"key":"b28-spine091015","series-title":"J Spinal Disord Tech","doi-asserted-by":"publisher","first-page":"493","DOI":"10.1097\/00024720-200310000-00009","article-title":"Anterior fusion and posterior correction of severe cervical kyphosis using pedicle screw fixation in a patient with neurofibromatosis: a case report","volume":"16","author":"Yonezawa","year":"2003"}],"container-title":["Journal of Neurosurgery: Spine"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/14\/1\/article-p93.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/14\/1\/article-p93.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg-spine\/14\/1\/article-p93.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,4,15]],"date-time":"2023-04-15T22:12:16Z","timestamp":1681596736000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg-spine\/14\/1\/article-p93.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,1]]},"references-count":28,"journal-issue":{"issue":"1"},"URL":"https:\/\/doi.org\/10.3171\/2010.9.spine091015","relation":{},"ISSN":["1547-5654"],"issn-type":[{"value":"1547-5654","type":"print"}],"subject":[],"published":{"date-parts":[[2011,1]]}}}