{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,30]],"date-time":"2026-05-30T09:06:27Z","timestamp":1780131987098,"version":"3.54.0"},"reference-count":52,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Although neuroendoscopic biopsy is routinely performed, the safety and validity of this procedure has been studied only in small numbers of patients in single-center reports. The Section of Neuroendoscopy of the Italian Neurosurgical Society invited some of its members to review their own experience, gathering a sufficient number of cases for a wide analysis.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>Retrospective data were collected by 7 centers routinely performing neuroendoscopic biopsies over a period of 10 years. Sixty patients with newly diagnosed intraventricular and paraventricular tumors were included. No patient harboring a colloid cyst was included. Data regarding clinical presentation, neuroimaging findings, operative techniques, pathological diagnosis, postoperative complications, and subsequent therapy were analyzed.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>In all patients, a neuroendoscopic tumor biopsy was performed. In 38 patients (64%), obstructive hydrocephalus was present. In addition to the tumor biopsy, 32 patients (53%) underwent endoscopic third ventriculostomy (ETV), and 7 (12%) underwent septum pellucidotomy. Only 2 patients required a ventriculoperitoneal shunt shortly after the endoscopy procedure because ETV was not feasible. The major complication due to the endoscopy procedure was ventricular hemorrhage noted on the postoperative images in 8 cases (13%). Only 2 patients were symptomatic and required medical therapy. Infection occurred in only 1 case, and the other complications were all reversible. In no case did clinically significant sequelae affect the patient's outcome. Tumor types ranged across the spectrum and included glioma (low- and high-grade [27%]), pure germinoma (15%), pineal parenchymal tumor (12%), primary neuroectodermal tumor (4%), lymphoma (9%), metastasis (4%), craniopharyngioma (6%), and other tumor types (13%). In 10% of patients, the pathological findings were inconclusive. According to diagnosis, specific therapy was performed in 35% of patients: 17% underwent microsurgical removal, and 18% underwent chemotherapy or radiotherapy.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>This is one of the largest series confirming the safety and validity of the neuroendoscopic biopsy procedure. Complications were relatively low (about 13%), and they were all reversible. Neuroendoscopic biopsy provided meaningful pathological data in 90% of patients, making subsequent tumor therapy feasible. Cerebrospinal fluid pathways can be restored by ETV or septum pellucidotomy (65%) to control intracranial hypertension. In light of the results obtained, a neuroendoscopic biopsy should be considered a possible alternative to the stereotactic biopsy in the diagnosis and treatment of ventricular or paraventricular tumors. Furthermore, it could be the only surgical procedure necessary for the treatment of selected tumors.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2011.1.focus10326","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T11:21:07Z","timestamp":1301656867000},"page":"E2","source":"Crossref","is-referenced-by-count":76,"title":["Neuroendoscopic biopsy of ventricular tumors: a multicentric experience"],"prefix":"10.3171","volume":"30","author":[{"given":"Piero Andrea","family":"Oppido","sequence":"first","affiliation":[{"name":"Department of Neurosurgery, National Cancer Institute IFO\u2014Regina Elena, Roma;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alessandro","family":"Fiorindi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Treviso Hospital, Padova University, Treviso;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lucia","family":"Benvenuti","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Livorno Hospital, Livorno;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabio","family":"Cattani","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Cancer Institute IFO\u2014Regina Elena, Roma;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Saverio","family":"Cipri","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Reggio Calabria Hospital, Reggio Calabria;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Michelangelo","family":"Gangemi","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Federico II University School of Medicine, Naples;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Umberto","family":"Godano","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bellaria Hospital, Bologna; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pierluigi","family":"Longatti","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Treviso Hospital, Padova University, Treviso;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carmelo","family":"Mascari","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Bellaria Hospital, Bologna; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Enzo","family":"Morace","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, National Cancer Institute IFO\u2014Regina Elena, Roma;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luigino","family":"Tosatto","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Padua University Hospital, Padova, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"issue":"Suppl 2","key":"b1-0300002","series-title":"Neurosurgery","first-page":"575","article-title":"Application of neuroendoscopy to intraventricular lesions","volume":"62","author":"Cappabianca","year":"2008"},{"key":"b2-0300002","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"267","DOI":"10.1227\/01.NEU.0000223504.29243.0B","article-title":"Neurofiberscopic biopsy of tumors of the pineal region and posterior third ventricle: indications, technique, complications, and results","volume":"59","author":"Chernov","year":"2006"},{"issue":"5 Suppl","key":"b3-0300002","series-title":"J Neurosurg","first-page":"340","article-title":"Endoscopic biopsy for intraventricular tumors in children","volume":"106","author":"Depreitere","year":"2007"},{"key":"b4-0300002","series-title":"Neurology","doi-asserted-by":"publisher","first-page":"1435","DOI":"10.1212\/01.wnl.0000210464.94122.e1","article-title":"MATILDE regimen followed by radiotherapy is an active strategy against primary CNS lymphomas","volume":"66","author":"Ferreri","year":"2006"},{"key":"b5-0300002","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"545","DOI":"10.3171\/jns.2001.94.4.0545","article-title":"Comprehensive assessment of hemorrhage risks and outcomes after stereotactic brain biopsy","volume":"94","author":"Field","year":"2001"},{"key":"b6-0300002","series-title":"Acta Neurochir (Wien)","doi-asserted-by":"publisher","first-page":"1235","DOI":"10.1007\/s00701-008-0155-7","article-title":"A restricted neuroendoscopic approach for pathological diagnosis of intraventricular and paraventricular tumours","volume":"150","author":"Fiorindi","year":"2008"},{"key":"b7-0300002","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"110","DOI":"10.1227\/00006123-197803000-00006","article-title":"Endoscopic biopsy of intraventricular tumors with the use of a ventriculofiberscope","volume":"2","author":"Fukushima","year":"1978"},{"key":"b8-0300002","series-title":"Minim Invasive Neurosurg","doi-asserted-by":"publisher","first-page":"70","DOI":"10.1055\/s-2001-16002","article-title":"Endoscopic surgery for pineal region tumors","volume":"44","author":"Gangemi","year":"2001"},{"key":"b9-0300002","series-title":"Minim Invasive Neurosurg","doi-asserted-by":"publisher","first-page":"265","DOI":"10.1055\/s-2007-990305","article-title":"Long-term outcome of endoscopic third ventriculostomy in obstructive hydrocephalus","volume":"50","author":"Gangemi","year":"2007"},{"key":"b10-0300002","series-title":"Cancer","doi-asserted-by":"publisher","first-page":"1749","DOI":"10.1002\/(SICI)1097-0142(19980501)82:9<1756::AID-CNCR23>3.0.CO;2-2","article-title":"The safety and efficacy of stereotactic biopsy for intracranial lesions","volume":"82","author":"Hall","year":"1998"},{"key":"b11-0300002","series-title":"Neurosurg Rev","first-page":"1","article-title":"Endoscopic third ventriculostomy for obstructive hydrocephalus","volume":"28","author":"Hellwig","year":"2005"},{"key":"b12-0300002","series-title":"Neurosurg Q","doi-asserted-by":"publisher","first-page":"207","DOI":"10.1097\/00013414-200309000-00006","article-title":"Surgery for third ventricular tumors","volume":"13","author":"Johnson","year":"2003"},{"key":"b13-0300002","series-title":"Radiographics","doi-asserted-by":"publisher","first-page":"1473","DOI":"10.1148\/rg.226025118","article-title":"From the archives of the AFIP. 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