{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,3]],"date-time":"2026-07-03T08:00:57Z","timestamp":1783065657936,"version":"3.54.6"},"reference-count":10,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["PED"],"published-print":{"date-parts":[[2011,4]]},"abstract":"<jats:p>Congenital central hypoventilation syndrome (CCHS) is a rare, idiopathic disorder characterized by a failure of automatic respiration. Abnormalities such as seizure disorder, failure to thrive, and Hirschsprung disease have been associated with CCHS. In this report, the authors discuss the use of vagal nerve stimulation (VNS) to treat a medically refractory seizure disorder in a child who had previously undergone placement of bilateral phrenic nerve stimulators for treatment of CCHS. Concomitant use of phrenic and vagal nerve stimulators has not previously been reported in the literature. No adverse reactions were noted with both devices working. Diaphragmatic pacing (DP) was clinically unaffected by VNS. The patient experienced a marked reduction in seizure frequency and severity following vagal nerve stimulator placement. Based on this case, the authors conclude that VNS is a potentially safe and efficacious treatment option for seizure disorder associated with CCHS in patients undergoing DP.<\/jats:p>","DOI":"10.3171\/2011.1.peds10520","type":"journal-article","created":{"date-parts":[[2011,4,1]],"date-time":"2011-04-01T15:18:48Z","timestamp":1301671128000},"page":"413-415","source":"Crossref","is-referenced-by-count":3,"title":["Vagal nerve stimulator placement for medically refractory seizures in a child treated with phrenic nerve pacing for congenital central hypoventilation syndrome"],"prefix":"10.3171","volume":"7","author":[{"given":"Brian D.","family":"Duty","sequence":"first","affiliation":[{"name":"Department of Urology, North Shore University Hospital Long Island Jewish Medical Center, Manhasset, New York; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan E.","family":"Wozniak","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nathan R.","family":"Selden","sequence":"additional","affiliation":[{"name":"Department of Neurological Surgery, Oregon Health & Science University, Portland, Oregon"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0070413","series-title":"Am J Respir Crit Care Med","doi-asserted-by":"publisher","first-page":"368","DOI":"10.1164\/ajrccm.160.1.16010","article-title":"Idiopathic congenital central hypoventilation syndrome: diagnosis and management","volume":"160","author":"American Thoracic Society","year":"1999"},{"key":"b2-0070413","series-title":"Neurosurgery Tricks of the Trade","article-title":"Vagus nerve stimulation","author":"Carlson","year":"2010"},{"key":"b3-0070413","series-title":"Sleep","doi-asserted-by":"publisher","first-page":"176","DOI":"10.1093\/sleep\/17.2.176","article-title":"Diaphragm pacing: review and reassessment","volume":"17","author":"Chervin","year":"1994"},{"key":"b4-0070413","series-title":"J R Soc Med","doi-asserted-by":"publisher","first-page":"479","DOI":"10.1177\/014107689809100907","article-title":"The control of breathing with reference to congenital central hypoventilation syndrome","volume":"91","author":"Child","year":"1998"},{"key":"b5-0070413","series-title":"Surgery","doi-asserted-by":"publisher","first-page":"25","DOI":"10.1016\/S0039-6060(05)80005-4","article-title":"Diaphragmatic pacing in children with congenital central alveolar hypoventilation syndrome","volume":"118","author":"Flageole","year":"1995"},{"key":"b6-0070413","series-title":"Medicine (Baltimore)","doi-asserted-by":"publisher","first-page":"487","DOI":"10.1097\/00005792-197011000-00003","article-title":"Failure of automatic control of ventilation (Ondine's curse). 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