{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,15]],"date-time":"2026-10-15T19:22:26Z","timestamp":1792092146543,"version":"4.4.0"},"reference-count":24,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"3","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2012,3]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The precise natural history of incidentally discovered meningiomas (IDMs) remains unknown. It has been reported that for symptomatic meningiomas, tumor location can be used to predict growth. As to whether the same is true for IDMs has not been reported. This study aims to answer this question and provide biological evidence for this assumption by extending the study to involve symptomatic cases.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>A total of 113 IDMs were analyzed by fine volumetry. A comparison of growth rates and patterns between skull base and non\u2013skull base IDMs was made. Subsequently, materials obtained from 210 patients with symptomatic meningiomas who were treated in the authors' hospital during the same period were included for a biological comparison between skull base and non\u2013skull base tumors using the MIB-1 index.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>The 110 patients with IDMs included 93 females and 17 males, with a mean follow-up period of 46.9 months. There were 38 skull base (34%) and 75 non\u2013skull base (66%) meningiomas. Forty-two (37%) did not exhibit growth of more than 15% of the volume, whereas 71 (63%) showed growth. Only 15 (39.5%) of 38 skull base meningiomas showed growth, whereas 56 (74.7%) of 75 non\u2013skull base meningiomas showed growth (p = 0.0004). In the 71 IDMs (15 skull base and 56 non\u2013skull base), there was no statistical difference between the 2 groups in terms of mean age, sex, follow-up period, or initial tumor volume. However, the percentage of growth (p = 0.002) was significantly lower and the doubling time (p = 0.008) was significantly higher in the skull base than in the non\u2013skull base tumor group. In subsequently analyzed materials from 94 skull base and 116 non\u2013skull base symptomatic meningiomas, the mean MIB-1 index for skull base tumors was markedly low (2.09%), compared with that for non\u2013skull base tumors (2.74%; p = 0.013).<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>Skull base IDMs tend not to grow, which is different from non\u2013skull base tumors. Even when IDMs grow, the rate of growth is significantly lower than that of non\u2013skull base tumors. The same conclusion with regard to biological behavior was confirmed in symptomatic cases based on MIB-1 index analyses. The authors' findings may impact the understanding of the natural history of IDMs, as well as strategies for management and treatment of IDMs and symptomatic meningiomas.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.11.jns11999","type":"journal-article","created":{"date-parts":[[2011,12,16]],"date-time":"2011-12-16T15:05:00Z","timestamp":1324047900000},"page":"574-580","source":"Crossref","is-referenced-by-count":123,"title":["Slower growth of skull base meningiomas compared with non\u2013skull base meningiomas based on volumetric and biological studies"],"prefix":"10.3171","volume":"116","author":[{"given":"Naoya","family":"Hashimoto","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Carter S.","family":"Rabo","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yoshiko","family":"Okita","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manabu","family":"Kinoshita","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naoki","family":"Kagawa","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasunori","family":"Fujimoto","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eiichi","family":"Morii","sequence":"additional","affiliation":[{"name":"Pathology, Osaka University Graduate School of Medicine, Suita;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Haruhiko","family":"Kishima","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Motohiko","family":"Maruno","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Osaka Prefectural Center for Adult Diseases, Osaka; and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amami","family":"Kato","sequence":"additional","affiliation":[{"name":"Department of Neurosurgery, Kinki University School of Medicine, Sayama, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Toshiki","family":"Yoshimine","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns11999","series-title":"Acta Neurochir (Wien)","first-page":"555","article-title":"Aggressive surgery and focal radiation in the management of meningiomas of the skull base: preservation of function with maintenance of local control","volume":"143","author":"Black","year":"2001"},{"issue":"4","key":"b2-jns11999","series-title":"Neurosurg Focus","first-page":"E5","article-title":"Stereotactic radiation treatment for benign meningiomas","volume":"23","author":"Elia","year":"2007"},{"key":"b3-jns11999","series-title":"J Neurosurg","first-page":"545","article-title":"Growth rate of incidental meningiomas","volume":"73","author":"Firsching","year":"1990"},{"key":"b4-jns11999","series-title":"Neurology","first-page":"1718","article-title":"The natural history of asymptomatic meningiomas in Olmsted County, Minnesota","volume":"51","author":"Go","year":"1998"},{"key":"b5-jns11999","series-title":"Int J Radiat Oncol Biol Phys","first-page":"1324","article-title":"Gamma knife radiosurgery for skull base meningiomas: long-term radiologic and clinical outcome","volume":"72","author":"Han","year":"2008"},{"key":"b6-jns11999","series-title":"J Neurosurg","first-page":"675","article-title":"Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas. 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