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On stereotactic insertion of the infusion cannula into the brainstem lesion, CED of nimustine hydrochloride was performed with real-time MR imaging to monitor the co-infused chelated gadolinium. The patient's preinfusion symptom of diplopia disappeared after treatment. Follow-up MR imaging revealed the response of the tumor. The authors report on a case of recurrent glioblastoma infiltrating the brainstem that regressed after CED of nimustine hydrochloride.<\/jats:p>","DOI":"10.3171\/2011.2.peds10407","type":"journal-article","created":{"date-parts":[[2016,12,27]],"date-time":"2016-12-27T13:07:55Z","timestamp":1482844075000},"page":"522-526","source":"Crossref","is-referenced-by-count":41,"title":["Regression of recurrent glioblastoma infiltrating the brainstem after convection-enhanced delivery of nimustine hydrochloride"],"prefix":"10.3171","volume":"7","author":[{"given":"Ryuta","family":"Saito","sequence":"first","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yukihiko","family":"Sonoda","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Toshihiro","family":"Kumabe","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ken-ichi","family":"Nagamatsu","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mika","family":"Watanabe","sequence":"additional","affiliation":[{"name":"Pathology, Tohoku University Graduate School of Medicine, Sendai, Miyagi, Japan"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Teiji","family":"Tominaga","sequence":"additional","affiliation":[{"name":"Departments of Neurosurgery and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-0070522","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"893","DOI":"10.3171\/jns.2003.99.5.0893","article-title":"Safety and efficacy of convection-enhanced delivery of gemcitabine or carboplatin in a malignant glioma model in rats","volume":"99","author":"Degen","year":"2003"},{"key":"b2-0070522","series-title":"J Neurooncol","doi-asserted-by":"publisher","first-page":"1","DOI":"10.1007\/s11060-009-0046-7","article-title":"Convection-enhanced delivery of free gadolinium with the recombinant immunotoxin MR1-1","volume":"98","author":"Ding","year":"2010"},{"key":"b3-0070522","series-title":"Neurol Res","article-title":"Long-term safety of combined intracerebral delivery of free gadolinium and targeted chemotherapeutic agent PRX321","author":"Ding","year":"2009"},{"key":"b4-0070522","series-title":"J Clin Oncol","doi-asserted-by":"publisher","first-page":"1266","DOI":"10.1200\/JCO.2005.04.6599","article-title":"Advances toward an understanding of brainstem gliomas","volume":"24","author":"Donaldson","year":"2006"},{"key":"b5-0070522","series-title":"J Neurosurg Pediatr","doi-asserted-by":"publisher","first-page":"259","DOI":"10.3171\/2008.11.PEDS08281","article-title":"Treatment of diffuse intrinsic brainstem gliomas: failed approaches and future strategies. 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