{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:24:58Z","timestamp":1792214698096,"version":"4.4.0"},"reference-count":38,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"2","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,8]]},"abstract":"<jats:sec>\n                    <jats:title>Object<\/jats:title>\n                    <jats:p>Seizures are the most frequent presenting symptom in patients with low-grade gliomas (LGGs), and significantly influence quality of life if they are uncontrolled. Achieving freedom from seizures is of utmost importance in surgical planning, but the factors associated with seizure control remain incompletely understood.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Methods<\/jats:title>\n                    <jats:p>The authors performed a systematic literature review of seizure outcomes after resection of LGGs causing seizures, examining 773 patients across 20 published series. Rates of seizure freedom were stratified across 7 variables: patient age, tumor location, preoperative seizure control with medication, seizure semiology, epilepsy duration, extent of resection, and the use of intraoperative electrocorticography (ECoG).<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Results<\/jats:title>\n                    <jats:p>Gross-total resection was most predictive of complete seizure freedom, when compared with subtotal resection (OR 3.41, 95% CI 2.36\u20134.93). Other predictors of seizure freedom included preoperative seizure control on antiepileptic medication (OR 2.12, 95% CI 1.33\u20133.38) and duration of seizures of \u2264 1 year (OR 1.85, 95% CI 1.22\u20132.79). Patients with simple partial seizure semiology achieved seizure freedom less often than those with complex partial, generalized, or mixed seizure types (OR 0.46, 95% CI 0.26\u20130.80). No significant differences in seizure outcome were observed between adults versus children, patients with temporal lobe versus extratemporal tumors, or with the use of intraoperative ECoG.<\/jats:p>\n                  <\/jats:sec>\n                  <jats:sec>\n                    <jats:title>Conclusions<\/jats:title>\n                    <jats:p>Seizure control is one of the most important considerations in planning surgery for low-grade brain tumors. Gross-total resection is a critical factor in achieving seizure freedom.<\/jats:p>\n                  <\/jats:sec>","DOI":"10.3171\/2011.3.jns1153","type":"journal-article","created":{"date-parts":[[2011,8,1]],"date-time":"2011-08-01T11:03:22Z","timestamp":1312196602000},"page":"240-244","source":"Crossref","is-referenced-by-count":227,"title":["Predictors of seizure freedom after resection of supratentorial low-grade gliomas"],"prefix":"10.3171","volume":"115","author":[{"given":"Dario J.","family":"Englot","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mitchel S.","family":"Berger","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicholas M.","family":"Barbaro","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edward F.","family":"Chang","sequence":"additional","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns1153","series-title":"J Child Neurol","first-page":"697","article-title":"Benign lesions accompanied by intractable epilepsy in children","volume":"24","author":"Alexiou","year":"2009"},{"key":"b2-jns1153","series-title":"Acta Neurochir (Wien)","first-page":"1211","article-title":"Outcome of adult patients with temporal lobe tumours and medically refractory focal epilepsy","volume":"149","author":"Bauer","year":"2007"},{"key":"b3-jns1153","series-title":"Neurology","first-page":"752","article-title":"The focal motor seizures as a false localizing sign","volume":"15","author":"Beatty","year":"1965"},{"key":"b4-jns1153","series-title":"Neurosurgery","first-page":"1203","article-title":"Temporal lobe surgery for intractable epilepsy in children: an analysis of outcomes in 126 children","volume":"59","author":"Benifla","year":"2006"},{"key":"b5-jns1153","series-title":"J Neurosurg","first-page":"62","article-title":"Low-grade gliomas associated with intractable epilepsy: seizure outcome utilizing electrocorticography during tumor resection","volume":"79","author":"Berger","year":"1993"},{"issue":"Suppl 9","key":"b6-jns1153","series-title":"Epilepsia","first-page":"79","article-title":"When drugs and surgery don't work","volume":"49","author":"Cascino","year":"2008"},{"issue":"3 Suppl","key":"b7-jns1153","series-title":"J Neurosurg","first-page":"280","article-title":"Surgical management of temporal lobe tumor-related epilepsy in children","volume":"102","author":"Cataltepe","year":"2005"},{"key":"b8-jns1153","series-title":"J Neurosurg","first-page":"227","article-title":"Seizure characteristics and control following resection in 332 patients with low-grade gliomas","volume":"108","author":"Chang","year":"2008"},{"key":"b9-jns1153","series-title":"Stereotact Funct Neurosurg","first-page":"35","article-title":"A retrospective study of the clinical outcomes and significant variables in the surgical treatment of temporal lobe tumor associated with intractable seizures","volume":"82","author":"Choi","year":"2004"},{"key":"b10-jns1153","series-title":"Expert Rev Neurother","first-page":"885","article-title":"Adverse effects of antiepileptic drugs: a brief overview of important issues","volume":"10","author":"Cramer","year":"2010"},{"key":"b11-jns1153","series-title":"Curr Opin Oncol","first-page":"543","article-title":"Surgery of low-grade gliomas: towards a \u2018functional neurooncology\u2019","volume":"21","author":"Duffau","year":"2009"},{"key":"b12-jns1153","series-title":"Acta Neurochir (Wien)","first-page":"563","article-title":"Medically intractable epilepsy from insular low-grade gliomas: improvement after an extended lesionectomy","volume":"144","author":"Duffau","year":"2002"},{"key":"b13-jns1153","series-title":"J Clin Neurosci","first-page":"36","article-title":"Unilateral motor epileptic seizures","volume":"2","author":"Eadie","year":"1995"},{"key":"b14-jns1153","series-title":"Surgical Treatment of the Epilepsies","first-page":"609","article-title":"Outcome with respect to epileptic seizures","author":"Engel","year":"1993"},{"key":"b15-jns1153","series-title":"Prog Brain Res","doi-asserted-by":"crossref","first-page":"147","DOI":"10.1016\/S0079-6123(09)17711-7","article-title":"Consciousness and epilepsy: why are complex-partial seizures complex?","volume":"177","author":"Englot","year":"2009"},{"key":"b16-jns1153","series-title":"Neurosurgery","first-page":"815","article-title":"Limbic and neocortical gliomas associated with intractable seizures: a distinct clinicopathological group","volume":"34","author":"Fried","year":"1994"},{"key":"b17-jns1153","series-title":"J Neurosurg","first-page":"1275","article-title":"Seizure outcome of epilepsy surgery in focal epilepsies associated with temporomesial glioneuronal tumors: lesionectomy compared with tailored resection. Clinical article","volume":"111","author":"Giulioni","year":"2009"},{"key":"b18-jns1153","series-title":"Brain","first-page":"364","article-title":"Localised convulsions from tumour of the brain","volume":"5","author":"Hughlings-Jackson","year":"1882"},{"key":"b19-jns1153","series-title":"J Neurosurg","first-page":"231","article-title":"Lesionectomy versus electrophysiologically guided resection for temporal lobe tumors manifesting with complex partial seizures","volume":"83","author":"Jooma","year":"1995"},{"key":"b20-jns1153","series-title":"Childs Nerv Syst","first-page":"634","article-title":"Intractable seizures associated with brain tumor in childhood: lesionectomy and seizure outcome","volume":"11","author":"Kim","year":"1995"},{"key":"b21-jns1153","series-title":"Brain Pathol","first-page":"255","article-title":"The new WHO classification of brain tumours","volume":"3","author":"Kleihues","year":"1993"},{"key":"b22-jns1153","series-title":"Ann Neurol","first-page":"514","article-title":"Epilepsy in low-grade gliomas: the impact on cognitive function and quality of life","volume":"54","author":"Klein","year":"2003"},{"key":"b23-jns1153","series-title":"Acta Neurochir Suppl (Wien)","first-page":"70","article-title":"Low grade glioma in intractable epilepsy: lesionectomy versus epilepsy surgery","volume":"68","author":"Lombardi","year":"1997"},{"key":"b24-jns1153","series-title":"Epilepsia","first-page":"822","article-title":"The spectrum of long-term epilepsy-associated tumors: long-term seizure and tumor outcome and neurosurgical aspects","volume":"44","author":"Luyken","year":"2003"},{"key":"b25-jns1153","series-title":"J Neurosurg","first-page":"998","article-title":"Seizure control following tumor surgery for childhood cortical low-grade gliomas","volume":"80","author":"Packer","year":"1994"},{"key":"b26-jns1153","series-title":"Neurol India","first-page":"66","article-title":"Electro-clinical characteristics and postoperative outcome of medically refractory tumoral temporal lobe epilepsy","volume":"53","author":"Panda","year":"2005"},{"issue":"Suppl 8","key":"b27-jns1153","series-title":"Epilepsia","first-page":"69","article-title":"Surgical treatment of the extratemporal epilepsies","volume":"50","author":"Roper","year":"2009"},{"issue":"Suppl 2","key":"b28-jns1153","series-title":"J Child Neurol","first-page":"2S23","article-title":"Adolescent issues in epilepsy","volume":"17","author":"Sheth","year":"2002"},{"issue":"6 Suppl 19","key":"b29-jns1153","series-title":"Semin Oncol","first-page":"45","article-title":"Neurocognitive sequelae in the treatment of lowgrade gliomas","volume":"30","author":"Taphoorn","year":"2003"},{"key":"b30-jns1153","series-title":"Lancet Neurol","first-page":"159","article-title":"Cognitive deficits in adult patients with brain tumours","volume":"3","author":"Taphoorn","year":"2004"},{"key":"b31-jns1153","series-title":"Epilepsia","first-page":"1132","article-title":"Significance of spikes recorded on intraoperative electrocorticography in patients with brain tumor and epilepsy","volume":"38","author":"Tran","year":"1997"},{"key":"b32-jns1153","series-title":"Lancet Neurol","first-page":"421","article-title":"Epilepsy in patients with brain tumours: epidemiology, mechanisms, and management","volume":"6","author":"van Breemen","year":"2007"},{"issue":"6 Suppl 1","key":"b33-jns1153","series-title":"Neurologist","first-page":"S44","article-title":"Management of epilepsy in oncological patients","volume":"14","author":"Villanueva","year":"2008"},{"key":"b34-jns1153","series-title":"Can J Neurol Sci","first-page":"33","article-title":"Role of electrocorticography at surgery for lesion-related frontal lobe epilepsy","volume":"26","author":"Wennberg","year":"1999"},{"key":"b35-jns1153","series-title":"N Engl J Med","first-page":"891","article-title":"Focal epilepsy; a statistical study of its causes and the results of surgical treatment; epilepsy secondary to intracranial tumors","volume":"238","author":"White","year":"1948"},{"key":"b36-jns1153","series-title":"Epilepsy Behav","first-page":"238","article-title":"A prospective study of loss of consciousness in epilepsy using virtual reality driving simulation and other video games","volume":"18","author":"Yang","year":"2010"},{"key":"b37-jns1153","series-title":"Neurology","first-page":"636","article-title":"Temporal lobe tumoral epilepsy: characteristics and predictors of surgical outcome","volume":"61","author":"Zaatreh","year":"2003"},{"key":"b38-jns1153","series-title":"Neurosurgery","first-page":"378","article-title":"Surgical treatment of neoplasms associated with medically intractable epilepsy","volume":"41","author":"Zentner","year":"1997"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/2\/article-p240.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/2\/article-p240.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/2\/article-p240.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,26]],"date-time":"2023-03-26T22:58:15Z","timestamp":1679871495000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/2\/article-p240.xml"}},"subtitle":["A review"],"short-title":[],"issued":{"date-parts":[[2011,8]]},"references-count":38,"journal-issue":{"issue":"2"},"URL":"https:\/\/doi.org\/10.3171\/2011.3.jns1153","relation":{"has-review":[{"id-type":"doi","id":"10.3410\/f.13328961.14692088","asserted-by":"object"}]},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,8]]}}}