{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,5]],"date-time":"2026-09-05T19:00:32Z","timestamp":1788634832554,"version":"build-2803163510"},"reference-count":78,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"1","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["FOC"],"published-print":{"date-parts":[[2011,7]]},"abstract":"<jats:p>The aim of this paper is to provide a comprehensive review of clinical, imaging, and histopathological features, as well as operative and nonoperative management strategies in patients with Rathke cleft cysts (RCCs).<\/jats:p>\n                  <jats:p>A literature review was performed to identify previous articles that reported surgical and nonsurgical management of RCCs. Rathke cleft cysts are often incidental lesions found in the sellar and suprasellar regions and do not require surgical intervention in the majority of cases. In symptomatic RCCs, the typical clinical presentation includes headache, visual loss, and\/or endocrine dysfunction. Visual field testing and endocrine laboratory studies may reveal more subtle deficiencies associated with RCCs. When indicated, the transsphenoidal approach typically offers the least invasive and safest method for treating these lesions. Various surgical strategies including cyst wall resection, intralesional alcohol injection, and sellar floor reconstruction are discussed. Although headache and visual symptoms frequently improve after surgical drainage of RCCs, hypopituitarism and diabetes insipidus are less likely to do so. A subset of more aggressive, atypical RCCs associated with pronounced clinical symptoms and higher recurrence rates is discussed, as well as the possible relationship of these lesions to craniopharyngiomas.<\/jats:p>\n                  <jats:p>Rathke cleft cysts are typically benign, asymptomatic lesions that can be monitored. In selected patients, transsphenoidal surgery provides excellent rates of improvement in clinical symptoms and long-term cyst resolution. Complete cyst wall resection, intraoperative alcohol cauterization, and sellar floor reconstruction in the absence of a CSF leak are not routinely recommended.<\/jats:p>","DOI":"10.3171\/2011.5.focus1183","type":"journal-article","created":{"date-parts":[[2011,7,1]],"date-time":"2011-07-01T09:58:21Z","timestamp":1309514301000},"page":"E1","source":"Crossref","is-referenced-by-count":118,"title":["Rathke cleft cysts: a review of clinical and surgical management"],"prefix":"10.3171","volume":"31","author":[{"given":"Gabriel","family":"Zada","sequence":"first","affiliation":[],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-0310001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"189","DOI":"10.3171\/jns.2005.102.2.0189","article-title":"Surgical outcomes in 118 patients with Rathke cleft cysts","volume":"102","author":"Aho","year":"2005"},{"key":"b2-0310001","series-title":"J Comput Assist Tomogr","doi-asserted-by":"publisher","first-page":"532","DOI":"10.1097\/00004728-199007000-00006","article-title":"MR appearance and cyst content of Rathke cleft cysts","volume":"14","author":"Asari","year":"1990"},{"key":"b3-0310001","series-title":"Neurosurgery","doi-asserted-by":"publisher","first-page":"766","DOI":"10.1227\/00006123-198506000-00005","article-title":"Symptomatic Rathke's cleft cysts located entirely in the suprasellar region: review of diagnosis, management, and pathogenesis","volume":"16","author":"Barrow","year":"1985"},{"key":"b4-0310001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"577","DOI":"10.3171\/jns.2004.101.4.0577","article-title":"Surgery for Rathke cleft cysts: technical considerations and outcomes","volume":"101","author":"Benveniste","year":"2004"},{"key":"b5-0310001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"837","DOI":"10.3171\/jns.2005.103.5.0837","article-title":"Rathke cleft cyst intracystic nodule: a characteristic magnetic resonance imaging finding","volume":"103","author":"Binning","year":"2005"},{"key":"b6-0310001","series-title":"J Neuroradiol","first-page":"162","article-title":"Rathke's cleft cysts: surgical-MRI correlation in 16 symptomatic cases","volume":"26","author":"Brassier","year":"1999"},{"key":"b7-0310001","series-title":"AJNR Am J Neuroradiol","first-page":"485","article-title":"MR imaging findings of Rathke's cleft cysts: significance of intracystic nodules","volume":"21","author":"Byun","year":"2000"},{"key":"b8-0310001","series-title":"Neurosurg Rev","doi-asserted-by":"publisher","first-page":"55","DOI":"10.1007\/s10143-007-0098-0","article-title":"The role of the endoscope in the transsphenoidal management of cystic lesions of the sellar region","volume":"31","author":"Cavallo","year":"2008"},{"key":"b9-0310001","series-title":"J Neurosurg","doi-asserted-by":"publisher","first-page":"318","DOI":"10.3171\/2010.5.JNS091905","article-title":"Rathke cleft cyst apoplexy: a newly characterized distinct clinical entity. 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