{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T04:11:30Z","timestamp":1790136690245,"version":"4.0.1"},"reference-count":36,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,10]]},"abstract":"\nObject<\/jats:title>\nThe aim of this study was to determine whether patients with neurofibromatosis Type 2 (NF2) who have intact ipsilateral cochlear nerves can have open-set speech discrimination following cochlear implantation.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nRecords of 7 patients with documented NF2 were reviewed to determine speech discrimination outcomes following cochlear implantation. Outcomes were measured using consonant-nucleus-consonant words and phonemes; Hearing in Noise Test sentences in quiet; and City University of New York sentences in quiet and in noise.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nPreoperatively, none of the patients had open-set speech discrimination. Five of the 7 patients had previously undergone excision of ipsilateral vestibular schwannoma (VS). One of the patients who received a cochlear implant had received radiation therapy for ipsilateral VS, and another was undergoing observation for a small ipsilateral VS. Following cochlear implantation, 4 of 7 patients with NF2 had open-set speech discrimination following cochlear implantation during extended follow-up (15\u2013120 months). Two of the 3 patients without open-set speech understanding had a prolonged period between ipsilateral VS resection and cochlear implantation (120 and 132 months), and had cochlear ossification at the time of implantation. The other patient without open-set speech understanding had good contralateral hearing at the time of cochlear implantation. Despite these findings, 6 of the 7 patients were daily users of their cochlear implants, and the seventh is an occasional user, indicating that all of the patients subjectively gained some benefit from their implants.<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nCochlear implantation can provide long-term auditory rehabilitation, with open-set speech discrimination for patients with NF2 who have intact ipsilateral cochlear nerves. Factors that can affect implant performance include the following: 1) a prolonged time between VS resection and implantation; and 2) cochlear ossification.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.5.jns101929","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T13:30:53Z","timestamp":1310736653000},"page":"827-834","source":"Crossref","is-referenced-by-count":54,"title":["Auditory rehabilitation of patients with neurofibromatosis Type 2 by using cochlear implants"],"prefix":"10.3171","volume":"115","author":[{"given":"Pamela C.","family":"Roehm","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jon Mallen-St.","family":"Clair","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Jethanamest","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"John G.","family":"Golfinos","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"},{"name":"Neurosurgery, New York University School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"William","family":"Shapiro","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Susan","family":"Waltzman","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Thomas","family":"Roland","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology and"},{"name":"Neurosurgery, New York University School of Medicine, New York, New York"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns101929","series-title":"Laryngoscope","first-page":"472","article-title":"Cochlear implantation concurrent with translabyrinthine acoustic neuroma resection","volume":"113","author":"Ahsan","year":"2003"},{"key":"b2-jns101929","series-title":"Otol Neurotol","first-page":"205","article-title":"Simultaneous cochlear implantation and translabyrinthine removal of vestibular schwannoma in an only hearing ear: report of two cases (neurofibromatosis type 2 and unilateral vestibular schwannoma)","volume":"26","author":"Ar\u00edstegui","year":"2005"},{"key":"b3-jns101929","series-title":"Otolaryngol Head Neck Surg","first-page":"325","article-title":"Simultaneous cochlear implantation and acoustic neuroma resection: imaging considerations, technique, and functional outcome","volume":"112","author":"Arriaga","year":"1995"},{"key":"b4-jns101929","series-title":"Lancet","first-page":"1974","article-title":"Neurofibromatosis type 2","volume":"373","author":"Asthagiri","year":"2009"},{"key":"b5-jns101929","series-title":"Laryngoscope","first-page":"1974","article-title":"Open set speech perception with auditory brainstem implant?","volume":"115","author":"Colletti","year":"2005"},{"key":"b6-jns101929","series-title":"Otol Neurotol","first-page":"558","article-title":"Complications in auditory brainstem implant surgery in adults and children","volume":"31","author":"Colletti","year":"2010"},{"issue":"Suppl 1","key":"b7-jns101929","series-title":"Cochlear Implants Int","first-page":"20","article-title":"Cochlear implantation after translabyrinthine acoustic tumour removal: preliminary results","volume":"6","author":"Denia","year":"2005"},{"key":"b8-jns101929","series-title":"Eur Arch Otorhinolaryngol","first-page":"5","article-title":"Auditory brainstem and cochlear implants: functional results obtained after one year of rehabilitation","volume":"258","author":"Di Nardo","year":"2001"},{"key":"b9-jns101929","series-title":"Otol Neurotol","first-page":"596","article-title":"Cochlear implantation in prelingually deaf children with ossified cochleae","volume":"24","author":"El-Kashlan","year":"2003"},{"key":"b10-jns101929","series-title":"GeneReviews","article-title":"Neurofibromatosis 2","author":"Evans","year":"1998"},{"key":"b11-jns101929","series-title":"Orphanet J Rare Dis","first-page":"16","article-title":"Neurofibromatosis type 2 (NF2): a clinical and molecular review","volume":"4","author":"Evans","year":"2009"},{"key":"b12-jns101929","series-title":"J Laryngol Otol","first-page":"458","article-title":"The magnetless Clarion cochlear implant in a patient with neurofibromatosis 2","volume":"113","author":"Graham","year":"1999"},{"key":"b13-jns101929","series-title":"Otolaryngol Head Neck Surg","first-page":"320","article-title":"Labyrinthitis ossificans: histopathologic consideration for cochlear implantation","volume":"104","author":"Green","year":"1991"},{"issue":"Suppl","key":"b14-jns101929","series-title":"Am J Otol","first-page":"3","article-title":"Ganglion cell populations in labyrinthitis ossificans","volume":"12","author":"Hinojosa","year":"1991"},{"key":"b15-jns101929","series-title":"Am J Otol","first-page":"525","article-title":"Cochlear implants in the management of bilateral acoustic neuromas","volume":"13","author":"Hoffman","year":"1992"},{"key":"b16-jns101929","series-title":"Arch Otolaryngol Head Neck Surg","first-page":"465","article-title":"Cochlear implantation in a patient after removal of an acoustic neuroma. 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