{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,12,15]],"date-time":"2025-12-15T04:24:24Z","timestamp":1765772664443},"reference-count":29,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"5","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,11]]},"abstract":"<jats:p>This case report of 74-year-old man with trigeminal neuralgia is presented to underscore the importance of evaluating the entire treatment plan, especially when delivering large doses where even a low percentage of the prescription dose can contribute a substantial dose to an unintended target. The patient was treated using the CyberKnife stereotactic radiosurgery system utilizing a nonisocentric beam treatment plan with a 5-mm fixed collimator generating 111 beams to deliver 6000 cGy to the 79% isodose line with a maximum dose of 7594 cGy to the target. Two weeks after treatment the patient's trigeminal neuralgia symptoms resolved; however, the patient developed oral mucositis due to the treatment. This case report reviews the cause of mucositis and makes recommendations on how to prevent unintended targets from receiving treatment.<\/jats:p>","DOI":"10.3171\/2011.6.jns102129","type":"journal-article","created":{"date-parts":[[2011,7,15]],"date-time":"2011-07-15T13:30:53Z","timestamp":1310736653000},"page":"940-944","source":"Crossref","is-referenced-by-count":3,"title":["CyberKnife radiosurgery for trigeminal neuralgia: unanticipated iatrogenic effect following successful treatment"],"prefix":"10.3171","volume":"115","author":[{"given":"Anuj V.","family":"Peddada","sequence":"first","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D. James","family":"Sceats","sequence":"additional","affiliation":[{"name":"Colorado Springs Neurosurgery and Neurology, Colorado Springs, Colorado"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gerald A.","family":"White","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gyongyver","family":"Bulz","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Greg L.","family":"Gibbs","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Barry","family":"Switzer","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Susan","family":"Anderson","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alan T.","family":"Monroe","sequence":"additional","affiliation":[{"name":"Department of Radiation Oncology, Penrose Cancer Center; and"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"issue":"Suppl","key":"b1-jns102129","series-title":"J Neurosurg","first-page":"185","article-title":"Gamma knife surgery for trigeminal neuralgia: improved initial response with two isocenters and increasing dose","volume":"102","author":"Alpert","year":"2005"},{"key":"b2-jns102129","series-title":"J Neurosurg","first-page":"730","article-title":"Does dose rate affect efficacy? The outcomes of 256 gamma knife surgery procedures for trigeminal neuralgia and other types of facial pain as they relate to the half-life of cobalt","volume":"105","author":"Balamucki","year":"2006"},{"key":"b3-jns102129","series-title":"J Neurol Neurosurg Psychiatry","first-page":"59","article-title":"Microvascular decompression for trigeminal neuralgia: comments on a series of 250 cases, including 10 patients with multiple sclerosis","volume":"68","author":"Broggi","year":"2000"},{"issue":"Suppl 3","key":"b4-jns102129","series-title":"J Neurosurg","first-page":"346","article-title":"Treatment of trigeminal neuralgia with linear accelerator radiosurgery: initial results","volume":"101","author":"Chen","year":"2004"},{"key":"b5-jns102129","series-title":"Int J Radiat Oncol Biol Phys","first-page":"397","article-title":"Efficacy and quality of life outcomes in patients with atypical trigeminal neuralgia treated with gamma-knife radiosurgery","volume":"69","author":"Dhople","year":"2007"},{"key":"b6-jns102129","series-title":"J Neurol Neurosurg Psychiatry","first-page":"1405","article-title":"Recurrent trigeminal neuralgia: long term outcome of repeat gamma knife radiosurgery","volume":"79","author":"Gellner","year":"2008"},{"key":"b7-jns102129","series-title":"Neurosurgery","first-page":"823","article-title":"Linear accelerator radiosurgery using 90 gray for essential trigeminal neuralgia: results and dose volume histogram analysis","volume":"53","author":"Goss","year":"2003"},{"key":"b8-jns102129","series-title":"Stereotact Funct Neurosurg","first-page":"135","article-title":"Review of the treatment of trigeminal neuralgia with gamma knife radiosurgery","volume":"86","author":"Guo","year":"2008"},{"key":"b9-jns102129","series-title":"Acta Neurochir Suppl (Wien)","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1007\/978-3-211-78205-7_6","article-title":"Gamma knife radiosurgery for medically refractory idiopathic trigeminal neuralgia","volume":"101","author":"Kang","year":"2008"},{"issue":"Suppl","key":"b10-jns102129","series-title":"J Neurosurg","first-page":"276","article-title":"Gamma knife surgery for refractory postherpetic trigeminal neuralgia: targeting in one session both the retrogasserian trigeminal nerve and the centromedian nucleus of the thalamus","volume":"102","author":"Keep","year":"2005"},{"key":"b11-jns102129","series-title":"J Neurosurg","first-page":"940","article-title":"Stereotactic radiosurgery for trigeminal neuralgia: a multiinstitutional study using the gamma unit","volume":"84","author":"Kondziolka","year":"1996"},{"key":"b12-jns102129","series-title":"Phys Med Biol","first-page":"3455","article-title":"Selective source blocking for Gamma Knife radiosurgery of trigeminal neuralgia based on analytical dose modelling","volume":"49","author":"Li","year":"2004"},{"issue":"5","key":"b13-jns102129","series-title":"Neurosurg Focus","first-page":"E9","article-title":"CyberKnife radiosurgery for idiopathic trigeminal neuralgia","volume":"18","author":"Lim","year":"2005"},{"key":"b14-jns102129","series-title":"Neurosurgery","first-page":"1254","article-title":"Gamma knife radiosurgery for trigeminal neuralgia: results and potentially predictive parameters\u2014part I: idiopathic trigeminal neuralgia","volume":"61","author":"Longhi","year":"2007"},{"key":"b15-jns102129","series-title":"J Neurosurg","first-page":"597","article-title":"Gamma knife surgery for idiopathic trigeminal neuralgia performed using a far-anterior cisternal target and a high dose of radiation","volume":"100","author":"Massager","year":"2004"},{"key":"b16-jns102129","series-title":"Prog Neurol Surg","doi-asserted-by":"crossref","first-page":"235","DOI":"10.1159\/000100123","article-title":"Radiosurgery for trigeminal neuralgia","volume":"20","author":"Massager","year":"2007"},{"key":"b17-jns102129","series-title":"Neurosurgery","first-page":"1295","article-title":"Gamma knife radiosurgery for trigeminal neuralgia","volume":"56","author":"McNatt","year":"2005"},{"issue":"Suppl 3","key":"b18-jns102129","series-title":"J Neurosurg","first-page":"152","article-title":"Gamma knife radiosurgery using 90 Gy for trigeminal neuralgia","volume":"93","author":"Nicol","year":"2000"},{"key":"b19-jns102129","series-title":"Clin J Pain","first-page":"317","article-title":"A prospective cost-effectiveness study of trigeminal neuralgia surgery","volume":"21","author":"Pollock","year":"2005"},{"key":"b20-jns102129","series-title":"J Neurosurg","first-page":"347","article-title":"Stereotactic radiosurgery for idiopathic trigeminal neuralgia","volume":"97","author":"Pollock","year":"2002"},{"key":"b21-jns102129","series-title":"Neurosurgery","first-page":"1401","article-title":"High-dose trigeminal neuralgia radiosurgery associated with increased risk of trigeminal nerve dysfunction","volume":"50","author":"R\u00e9gis","year":"2002"},{"key":"b22-jns102129","series-title":"J Neurosurg","first-page":"199","article-title":"Long-term outcome after gamma knife surgery for secondary trigeminal neuralgia","volume":"95","author":"R\u00e9gis","year":"2001"},{"key":"b23-jns102129","series-title":"J Neurosurg","first-page":"913","article-title":"Prospective controlled trial of gamma knife surgery for essential trigeminal neuralgia","volume":"104","author":"R\u00e9gis","year":"2006"},{"key":"b24-jns102129","series-title":"Stereotact Funct Neurosurg","first-page":"105","article-title":"Cyberknife radiosurgery for trigeminal neuralgia","volume":"81","author":"Romanelli","year":"2003"},{"key":"b25-jns102129","series-title":"J Neurosurg","first-page":"511","article-title":"Dedicated linear accelerator radiosurgery for the treatment of trigeminal neuralgia","volume":"99","author":"Smith","year":"2003"},{"key":"b26-jns102129","series-title":"J Neurosurg","first-page":"442","article-title":"Stereotactic gamma knife surgery for trigeminal neuralgia: detailed analysis of treatment response","volume":"102","author":"Tawk","year":"2005"},{"key":"b27-jns102129","series-title":"J Neurosurg","first-page":"527","article-title":"Predictors of outcome in surgically managed patients with typical and atypical trigeminal neuralgia: comparison of results following microvascular decompression","volume":"96","author":"Tyler-Kabara","year":"2002"},{"key":"b28-jns102129","series-title":"Neurosurgery","first-page":"647","article-title":"Cyberknife radiosurgery for trigeminal neuralgia treatment: a preliminary multicenter experience","volume":"62","author":"Villavicencio","year":"2008"},{"key":"b29-jns102129","series-title":"Stereotact Funct Neurosurg","first-page":"29","article-title":"Stereotactic radiosurgery for primary trigeminal neuralgia using the Leksell Gamma unit","volume":"76","author":"Zheng","year":"2001"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/5\/article-p940.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/5\/article-p940.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/5\/article-p940.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:46:00Z","timestamp":1679885160000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/5\/article-p940.xml"}},"subtitle":["Case report"],"short-title":[],"issued":{"date-parts":[[2011,11]]},"references-count":29,"journal-issue":{"issue":"5"},"URL":"https:\/\/doi.org\/10.3171\/2011.6.jns102129","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,11]]}}}