{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:44:13Z","timestamp":1790023453906,"version":"4.0.1"},"reference-count":35,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"6","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,12]]},"abstract":"\nObject<\/jats:title>\nLittle is known about the epidemiology of meningioma, the most frequently reported primary brain tumor in the US. The authors undertook a case-control study to examine the relationship between family and personal medical history and meningioma risk.<\/jats:p><\/jats:sec>\n\nMethods<\/jats:title>\nThe authors compared the personal and first-degree family histories of 1124 patients with meningioma (age range 20\u201379 years) in Connecticut, Massachusetts, North Carolina, the San Francisco Bay Area, and 8 Houston counties between May 1, 2006, and February 26, 2010, and the histories of 1000 control individuals who were frequency-matched for age, sex, and geography.<\/jats:p><\/jats:sec>\n\nResults<\/jats:title>\nThe patients were more likely than the controls to report a first-degree family history of meningioma (OR 4.4, 95% CI 1.6\u201311.5), and there was an even stronger association in younger cases. The patients were less likely than controls to report immune conditions including allergy (OR 0.6, 95% CI 0.5\u20130.7) but were more likely to report a history of thyroid cancer (OR 4.7, 95% CI 1.02\u201321.5) or leukemia (OR 5.4, 95% CI 1.2\u201324.1) (most after radiotherapy). Among women, patients were more likely than controls to report hormonally related conditions\u2014uterine fibroid tumors (OR 1.2, 95% CI 1.0\u20131.5), endometriosis (OR 1.5, 95% CI 1.5\u20132.1), and breast cancer (OR 1.4, 95% CI 0.8\u20132.3).<\/jats:p><\/jats:sec>\n\nConclusions<\/jats:title>\nThe influence of genetics, the immune system, and radiation near the head on meningioma risk is suggested in the authors' findings; the role of hormones is intriguing but requires further study.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.6.jns11129","type":"journal-article","created":{"date-parts":[[2011,7,22]],"date-time":"2011-07-22T14:00:14Z","timestamp":1311343214000},"page":"1072-1077","source":"Crossref","is-referenced-by-count":72,"title":["Family and personal medical history and risk of meningioma"],"prefix":"10.3171","volume":"115","author":[{"given":"Elizabeth B.","family":"Claus","sequence":"first","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut;"},{"name":"Department of Neurosurgery, Brigham and Women's Hospital, Boston, Massachusetts"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Lisa","family":"Calvocoressi","sequence":"additional","affiliation":[{"name":"Department of Epidemiology and Public Health, Yale University School of Medicine, New Haven, Connecticut;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa L.","family":"Bondy","sequence":"additional","affiliation":[{"name":"Department of Epidemiology, M. D. Anderson Cancer Center, Houston, Texas;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joellen M.","family":"Schildkraut","sequence":"additional","affiliation":[{"name":"Department of Community and Family Medicine, Duke University School of Medicine, Durham, North Carolina;"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joseph L.","family":"Wiemels","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics, and"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Margaret","family":"Wrensch","sequence":"additional","affiliation":[{"name":"Departments of Epidemiology and Biostatistics, and"},{"name":"Neurological Surgery, University of California, San Francisco School of Medicine, San Francisco, California; and"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1754","reference":[{"key":"b1-jns11129","series-title":"Int J Cancer","first-page":"1692","article-title":"Hormone replacement therapy and incidence of central nervous system tumours in the Million Women Study","volume":"127","author":"Benson","year":"2010"},{"key":"b2-jns11129","series-title":"Eur J Epidemiol","first-page":"433","article-title":"History of allergic disease and epilepsy and risk of glioma and meningioma (INTERPHONE study group, Germany)","volume":"24","author":"Berg-Beckhoff","year":"2009"},{"key":"b3-jns11129","series-title":"J Natl Cancer Inst","first-page":"270","article-title":"Comprehensive analysis of DNA repair gene variants and risk of meningioma","volume":"100","author":"Bethke","year":"2008"},{"key":"b4-jns11129","series-title":"Int J Cancer","first-page":"252","article-title":"History of allergies and autoimmune diseases and risk of brain tumors in adults","volume":"99","author":"Brenner","year":"2002"},{"key":"b5-jns11129","series-title":"CBTRUS Statistical Report: Primary Brain and Central Nervous System Tumors Diagnosed in the United States, 2004\u20132006, February 2010","author":"Central Brain Tumor Registry of the United States"},{"key":"b6-jns11129","series-title":"Cancer","first-page":"471","article-title":"Exogenous hormone use and meningioma risk: what do we tell our patients?","volume":"110","author":"Claus","year":"2007"},{"key":"b7-jns11129","series-title":"Cancer Res","first-page":"314","article-title":"Specific genes expressed in association with progesterone receptors in meningioma","volume":"68","author":"Claus","year":"2008"},{"key":"b8-jns11129","series-title":"BMC Cancer","first-page":"152","article-title":"Hormonal exposures and the risk of intracranial meningioma in women: a population-based case-control study","volume":"6","author":"Custer","year":"2006"},{"key":"b9-jns11129","series-title":"Cancer","first-page":"1626","article-title":"The association between breast carcinoma and meningioma in women","volume":"94","author":"Custer","year":"2002"},{"key":"b10-jns11129","series-title":"Int J Cancer","first-page":"797","article-title":"Reproductive and hormonal factors and risk of brain tumors in adult females","volume":"114","author":"Hatch","year":"2005"},{"key":"b11-jns11129","series-title":"Cancer Causes Control","first-page":"195","article-title":"Parental cancer as a risk factor for brain tumors (Sweden)","volume":"12","author":"Hemminki","year":"2001"},{"key":"b12-jns11129","series-title":"Lancet Oncol","first-page":"481","article-title":"Familial risks in nervous-system tumours: a histology-specific analysis from Sweden and Norway","volume":"10","author":"Hemminki","year":"2009"},{"key":"b13-jns11129","series-title":"JAMA","first-page":"1207","article-title":"Cumulative incidence of secondary neoplasms as a first event after childhood acute lymphoblastic leukemia","volume":"297","author":"Hijiya","year":"2007"},{"key":"b14-jns11129","series-title":"J Neurosurg","first-page":"848","article-title":"Sex steroid hormone exposures and risk for meningioma","volume":"99","author":"Jhawar","year":"2003"},{"key":"b15-jns11129","series-title":"Int J Cancer","first-page":"389","article-title":"Reproductive factors and the risk of brain tumors: a population-based study in Sweden","volume":"72","author":"Lambe","year":"1997"},{"key":"b16-jns11129","series-title":"Int J Cancer","first-page":"1152","article-title":"Association of meningioma with reproductive factors","volume":"119","author":"Lee","year":"2006"},{"key":"b17-jns11129","series-title":"Cancer","first-page":"639","article-title":"Epidemiology of intracranial meningioma","volume":"72","author":"Longstreth","year":"1993"},{"key":"b18-jns11129","series-title":"Int J Cancer","first-page":"260","article-title":"Familial brain tumours-genetics or environment? A nationwide cohort study of cancer risk in spouses and first-degree relatives of brain tumour patients","volume":"106","author":"Malmer","year":"2003"},{"key":"b19-jns11129","series-title":"J Natl Cancer Inst","first-page":"1555","article-title":"Tumors of the nervous system and pituitary gland associated with atomic bomb radiation exposure","volume":"94","author":"Preston","year":"2002"},{"key":"b20-jns11129","series-title":"Neuroepidemiology","first-page":"283","article-title":"Descriptive epidemiology of primary tumors of the brain, cranial nerves and cranial meninges in Los Angeles County","volume":"8","author":"Preston-Martin","year":"1989"},{"key":"b21-jns11129","series-title":"Natl Cancer Inst Monogr","first-page":"175","article-title":"Medical and dental x rays as risk factors for recently diagnosed tumors of the head","volume":"69","author":"Preston-Martin","year":"1985"},{"key":"b22-jns11129","series-title":"Cancer Res","first-page":"6137","article-title":"Risk factors for gliomas and meningiomas in males in Los Angeles County","volume":"49","author":"Preston-Martin","year":"1989"},{"key":"b23-jns11129","series-title":"J Natl Cancer Inst","first-page":"67","article-title":"Case-control study of intracranial meningiomas in women in Los Angeles County, California","volume":"65","author":"Preston-Martin","year":"1980"},{"key":"b24-jns11129","series-title":"J Natl Cancer Inst","first-page":"863","article-title":"Risk factors for meningiomas in men in Los Angeles County","volume":"70","author":"Preston-Martin","year":"1983"},{"key":"b25-jns11129","series-title":"Neurosurgery","first-page":"483","article-title":"The association of breast cancer and meningioma in men and women","volume":"65","author":"Rao","year":"2009"},{"key":"b26-jns11129","series-title":"N Engl J Med","first-page":"1033","article-title":"Tumors of the brain and nervous system after radiotherapy in childhood","volume":"319","author":"Ron","year":"1988"},{"key":"b27-jns11129","series-title":"Int J Cancer","first-page":"20","article-title":"Risk factors for tumors of the brain and meninges: results from the Adelaide Adult Brain Tumor Study","volume":"51","author":"Ryan","year":"1992"},{"key":"b28-jns11129","series-title":"Cancer Epidemiol Biomarkers Prev","first-page":"969","article-title":"Genotyping of patients with sporadic and radiation-associated meningiomas","volume":"14","author":"Sadetzki","year":"2005"},{"key":"b29-jns11129","series-title":"Int J Cancer","first-page":"155","article-title":"Role of medical history in brain tumour development. Results from the international adult brain tumour study","volume":"82","author":"Schlehofer","year":"1999"},{"key":"b30-jns11129","series-title":"Am J Epidemiol","first-page":"477","article-title":"History of allergic disease and risk of meningioma","volume":"165","author":"Schoemaker","year":"2007"},{"key":"b31-jns11129","series-title":"Int J Cancer","first-page":"423","article-title":"Cohort studies of association between self-reported allergic conditions, immune-related diagnoses and glioma and meningioma risk","volume":"106","author":"Schwartzbaum","year":"2003"},{"key":"b32-jns11129","series-title":"N Engl J Med","first-page":"1821","article-title":"Incidental findings on brain MRI in the general population","volume":"357","author":"Vernooij","year":"2007"},{"key":"b33-jns11129","series-title":"J Neurooncol","first-page":"307","article-title":"Epidemiology and etiology of meningioma","volume":"99","author":"Wiemels","year":"2010"},{"key":"b34-jns11129","series-title":"Am J Epidemiol","first-page":"629","article-title":"Risk of brain tumors associated with exposure to exogenous female sex hormones","volume":"164","author":"Wigertz","year":"2006"},{"key":"b35-jns11129","series-title":"Am J Epidemiol","first-page":"941","article-title":"Allergic conditions and brain tumor risk","volume":"166","author":"Wigertz","year":"2007"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/6\/article-p1072.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/6\/article-p1072.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/6\/article-p1072.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:38:43Z","timestamp":1679884723000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/6\/article-p1072.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,12]]},"references-count":35,"journal-issue":{"issue":"6"},"URL":"https:\/\/doi.org\/10.3171\/2011.6.jns11129","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,12]]}}}