{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,8,30]],"date-time":"2025-08-30T16:27:12Z","timestamp":1756571232854},"reference-count":30,"publisher":"Journal of Neurosurgery Publishing Group (JNSPG)","issue":"4","content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["JNS"],"published-print":{"date-parts":[[2011,10]]},"abstract":"<jats:sec>\n<jats:title>Object<\/jats:title>\n<jats:p>The authors describe the unique occurrence of nodular enhancement within the fundus of the internal auditory canal (IAC) lateral to the preoperative radiological tumor margin following gross-total vestibular schwannoma (VS) resection.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Methods<\/jats:title>\n<jats:p>The nature of the study was a retrospective chart review of records. The authors reviewed the cases of all patients who underwent microsurgical resection of a VS between January 2000 and January 2010 at a single tertiary referral center. Patients with incomplete resection, neurofibromatosis Type 2, and those with fewer than 2 postoperative MR images available for review were excluded.<\/jats:p>\n<jats:p>Postsurgical patients with IAC enhancement located lateral to the preoperative imaging\u2013delineated tumor margin were identified. Lesion morphology was characterized on serial MR imaging studies. Clinical follow-up and outcomes were recorded.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Results<\/jats:title>\n<jats:p>Over the past decade, 350 patients underwent microsurgical VS resection. Of these, 16 patients met study criteria and were found to have postsurgical enhancement in the distal aspect of the IAC lateral to the imaging limits of the preoperative tumor margin on the first postoperative MR imaging study (37.5% women, median age 45 years). Initial MR imaging was performed at a mean of 3.1 months following surgery, and the mean radiological follow-up duration was 39.8 months (range 16.4\u2013101.9 months). None of the 16 patients developed recurrence during the follow-up course.<\/jats:p><\/jats:sec>\n<jats:sec>\n<jats:title>Conclusions<\/jats:title>\n<jats:p>In contrast to previous publications that have reported a high rate of recurrence in cases involving nodular enhancement within the original tumor bed, postoperative enhancement in the IAC lateral to the original tumor margin appears to carry much less risk for tumor recurrence. These findings may be helpful when counseling patients on the recommended frequency of postoperative follow-up imaging.<\/jats:p><\/jats:sec>","DOI":"10.3171\/2011.6.jns11772","type":"journal-article","created":{"date-parts":[[2011,7,8]],"date-time":"2011-07-08T20:26:46Z","timestamp":1310156806000},"page":"835-841","source":"Crossref","is-referenced-by-count":8,"title":["Nodular enhancement within the internal auditory canal following retrosigmoid vestibular schwannoma resection: a unique radiological pattern"],"prefix":"10.3171","volume":"115","author":[{"given":"Matthew L.","family":"Carlson","sequence":"first","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kathryn M.","family":"Van Abel","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"William R.","family":"Schmitt","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Colin L. W.","family":"Driscoll","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"},{"name":"Neurologic Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Brian A.","family":"Neff","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"John I.","family":"Lane","sequence":"additional","affiliation":[{"name":"Radiology, and"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael J.","family":"Link","sequence":"additional","affiliation":[{"name":"Departments of Otolaryngology Head and Neck Surgery,"},{"name":"Neurologic Surgery, Mayo Clinic School of Medicine, Rochester, Minnesota"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1754","reference":[{"key":"b1-jns11772","series-title":"Otolaryngol Head Neck Surg","first-page":"179","article-title":"Committee on Hearing and Equilibrium guidelines for the evaluation of hearing preservation in acoustic neuroma (vestibular schwannoma)","volume":"113","author":"American Academy of Otolaryngology\u2013Head and Neck Surgery Foundation","year":"1995"},{"key":"b2-jns11772","series-title":"Otolaryngol Clin North Am","first-page":"521","article-title":"Guiding patients through the choices for treating vestibular schwannomas: balancing options and ensuring informed consent","volume":"40","author":"Backous","year":"2007"},{"key":"b3-jns11772","series-title":"Laryngoscope","first-page":"1168","article-title":"Residual and recurrent acoustic neuromas","volume":"97","author":"Beatty","year":"1987"},{"key":"b4-jns11772","series-title":"Otolaryngol Head Neck Surg","first-page":"667","article-title":"Post-operative imaging of vestibular schwannomas","volume":"138","author":"Bennett","year":"2008"},{"key":"b5-jns11772","series-title":"Otolaryngol Head Neck Surg","first-page":"81","article-title":"Exposure of the lateral extremity of the internal auditory canal through the retrosigmoid approach: a radioanatomic study","volume":"111","author":"Blevins","year":"1994"},{"key":"b6-jns11772","series-title":"Otolaryngol Head Neck Surg","first-page":"104","article-title":"The fate of the tumor remnant after less-than-complete acoustic neuroma resection","volume":"130","author":"Bloch","year":"2004"},{"key":"b7-jns11772","series-title":"Laryngoscope","first-page":"420","article-title":"Postoperative magnetic resonance imaging findings after transtemporal and translabyrinthine vestibular schwannoma resection","volume":"113","author":"Brors","year":"2003"},{"key":"b8-jns11772","series-title":"Radiology","first-page":"99","article-title":"Meninges: benign postoperative enhancement on MR images","volume":"174","author":"Burke","year":"1990"},{"key":"b9-jns11772","series-title":"Radiology","first-page":"93","article-title":"Cranial postoperative site: assessment with contrast-enhanced MR imaging","volume":"174","author":"Elster","year":"1990"},{"key":"b10-jns11772","series-title":"ORL J Otorhinolaryngol Relat Spec","first-page":"87","article-title":"Evaluation of the results of endoscope-assisted acoustic neuroma surgery through posterior fossa approach","volume":"67","author":"G\u00f6ksu","year":"2005"},{"key":"b11-jns11772","series-title":"Neurosurg Clin N Am","first-page":"217","article-title":"Selection of surgical approach to acoustic neuroma. 1992","volume":"19","author":"Jackler","year":"2008"},{"key":"b12-jns11772","series-title":"AJNR Am J Neuroradiol","first-page":"115","article-title":"MR enhancement of the internal auditory canal induced by tissue implant after resection of acoustic neurinoma","volume":"19","author":"Kremer","year":"1998"},{"key":"b13-jns11772","series-title":"Otol Neurotol","first-page":"102","article-title":"Postoperative imaging and follow-up of vestibular schwannomas","volume":"26","author":"Lee","year":"2005"},{"key":"b14-jns11772","series-title":"J Clin Neurosci","first-page":"253","article-title":"Seeding metastases of a benign intraventricular meningioma along the surgical track","volume":"17","author":"Mahore","year":"2010"},{"key":"b15-jns11772","series-title":"Skull Base Surg","first-page":"105","article-title":"Residual and recurrent acoustic neuroma in hearing preservation procedures: neuroradiologic and surgical findings","volume":"6","author":"Mazzoni","year":"1996"},{"key":"b16-jns11772","series-title":"Laryngoscope","first-page":"804","article-title":"The effect of intracranial surgical trauma on gadolinium-enhanced magnetic resonance imaging","volume":"104","author":"Millen","year":"1994"},{"key":"b17-jns11772","series-title":"Otol Neurotol","first-page":"697","article-title":"An anatomic and radiologic evaluation of access to the lateral internal auditory canal via the retrosigmoid approach and description of an internal labyrinthectomy","volume":"27","author":"Miller","year":"2006"},{"key":"b18-jns11772","series-title":"Otol Neurotol","first-page":"478","article-title":"Acoustic neuroma growth: a systematic review of the evidence","volume":"31","author":"Nikolopoulos","year":"2010"},{"key":"b19-jns11772","series-title":"J Neurosurg","first-page":"362","article-title":"Bone wax as a cause of foreign body granuloma in the cerebellopontine angle. Case illustration","volume":"92","author":"Patel","year":"2000"},{"key":"b20-jns11772","series-title":"J Neurosurg","first-page":"452","article-title":"Iatrogenic cerebellar implantation of a vestibular schwannoma. Case report","volume":"104","author":"Patrick","year":"2006"},{"issue":"6 Suppl","key":"b21-jns11772","series-title":"Neurosurgery","first-page":"53","article-title":"Image-guided, endoscopic-assisted drilling and exposure of the whole length of the internal auditory canal and its fundus with preservation of the integrity of the labyrinth using a retrosigmoid approach: a laboratory investigation","volume":"65","author":"Pillai","year":"2009"},{"key":"b22-jns11772","series-title":"Neurosurgery","first-page":"11","article-title":"Management of 1000 vestibular schwannomas (acoustic neuromas): surgical management and results with an emphasis on complications and how to avoid them","volume":"40","author":"Samii","year":"1997"},{"key":"b23-jns11772","series-title":"Otol Neurotol","first-page":"980","article-title":"Treatment of residual vestibular schwannoma","volume":"23","author":"Sanna","year":"2002"},{"key":"b24-jns11772","series-title":"Acta Neurochir (Wien)","first-page":"313","article-title":"Postoperative intracranial seeding of craniopharyngiomas\u2014report of three cases and review of the literature","volume":"152","author":"Schmalisch","year":"2010"},{"key":"b25-jns11772","series-title":"Neurosurgery","first-page":"587","article-title":"Changes in intracochlear and intracanalicular nerves after acoustic neurinoma excision confirmed by magnetic resonance imaging","volume":"27","author":"Sekiya","year":"1990"},{"key":"b26-jns11772","series-title":"Laryngoscope","first-page":"958","article-title":"Unilateral acoustic tumors: how often do they recur after translabyrinthine removal?","volume":"105","author":"Shelton","year":"1995"},{"key":"b27-jns11772","series-title":"Arch Otolaryngol Head Neck Surg","first-page":"1244","article-title":"Gadolinium. The new gold standard for diagnosing cerebellopontine angle tumors","volume":"115","author":"Sidman","year":"1989"},{"key":"b28-jns11772","series-title":"Neuroradiology","first-page":"317","article-title":"Baseline and follow-up MRI of the internal auditory canal after suboccipital resection of acoustic schwannoma: appearances and clinical correlations","volume":"37","author":"Smith","year":"1995"},{"key":"b29-jns11772","series-title":"J Neurooncol","first-page":"167","article-title":"Metastatic seeding of the stereotactic biopsy tract in glioblastoma multiforme: case report and review of the literature","volume":"55","author":"Steinmetz","year":"2001"},{"key":"b30-jns11772","series-title":"Neurol Med Chir (Tokyo)","first-page":"141","article-title":"Postoperative magnetic resonance imaging after acoustic neuroma surgery: influence of packing materials in the drilled internal auditory canal on assessment of residual tumor","volume":"39","author":"Umezu","year":"1999"}],"container-title":["Journal of Neurosurgery"],"original-title":[],"link":[{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/4\/article-p835.xml","content-type":"text\/html","content-version":"vor","intended-application":"text-mining"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/4\/article-p835.xml","content-type":"text\/html","content-version":"vor","intended-application":"syndication"},{"URL":"https:\/\/thejns.org\/downloadpdf\/journals\/j-neurosurg\/115\/4\/article-p835.xml","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2023,3,27]],"date-time":"2023-03-27T02:12:31Z","timestamp":1679883151000},"score":1,"resource":{"primary":{"URL":"https:\/\/thejns.org\/view\/journals\/j-neurosurg\/115\/4\/article-p835.xml"}},"subtitle":["Clinical article"],"short-title":[],"issued":{"date-parts":[[2011,10]]},"references-count":30,"journal-issue":{"issue":"4"},"URL":"https:\/\/doi.org\/10.3171\/2011.6.jns11772","relation":{},"ISSN":["0022-3085","1933-0693"],"issn-type":[{"value":"0022-3085","type":"print"},{"value":"1933-0693","type":"electronic"}],"subject":[],"published":{"date-parts":[[2011,10]]}}}